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POLR2L

Official Full Name

polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Overview

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.
Synonyms

POLR2L; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; polymerase (RNA) II (DNA directed) polypeptide L (7.6kD); DNA-directed RNA polymerases I, II, and III subunit RPABC5; hRPB7.6; hsRPB10b; RBP10; RPABC5; RPB7.6; RPB10beta; DNA directed RNA polymerase II polypeptide L; RNA polymerase II polypeptide L; RPB10; RPB10 homolog; RNA polymerase II 7.6 kDa subunit; DNA-directed RNA polymerase III subunit L; RNA polymerases I, II, and III subunit ABC5;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLR2L-1849H	Recombinant Human POLR2L, GST-tagged	E.coli	GST	1-67aa	$319 / 25ug
Human	POLR2L-30688TH	Recombinant Human POLR2L	E.coli	N/A		Inquiry
Human	POLR2L-3056H	Recombinant Human POLR2L, His-tagged	E.coli	His		Inquiry
Human	POLR2L-3027HCL	Recombinant Human POLR2L 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	POLR2L-13102M	Recombinant Mouse POLR2L Protein	Mammalian Cell	His		Inquiry
Mouse	Polr2l-5002M	Recombinant Mouse Polr2l Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	POLR2L-6927M-B	Recombinant Mouse POLR2L Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	POLR2L-6927M	Recombinant Mouse POLR2L Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	POLR2L-3519R	Recombinant Rhesus monkey POLR2L Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	POLR2L-3337R	Recombinant Rhesus Macaque POLR2L Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	POLR2L-3337R-B	Recombinant Rhesus Macaque POLR2L Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	POLR2L-7432Z	Recombinant Zebrafish POLR2L	Mammalian Cell	His		Inquiry
Chicken	POLR2L-5644C	Recombinant Chicken POLR2L	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

POLR2L involved in several pathways and played different roles in them. We selected most pathways POLR2L participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	POLR3A;ADSSL;POLR3GLB;POLE3;AMPD3B;CECR1;PDE4B;PDE2A;POLA1
Pyrimidine metabolism	ENTPD5;DPYDB;UPB1;TWISTNB;POLR2J3;NME2B.1;NME7;NME5;TYMS
Metabolic pathways	FAXDC2;POLE4;GALNTL1;IL4I1;SC4MOL;QDPR;ACAT1;POLE2;AHCYL2
RNA polymerase	POLR3B;POLR1C;POLR2D;POLR2K;POLR2J2;POLR3GL;POLR1E;POLR2A;POLR1A
Cytosolic DNA-sensing pathway	POLR2L;POLR1D;IFNA12;POLR3GL;POLR3F;NFKBIA;POLR1C;IFNPHI1;AIM2
Huntingtons disease	CASP8;DNAL4;DNAIC2;HAP1;UQCR10;POLR2I;UQCRQ;SDHB;NRF1
Epstein-Barr virus infection	SFPI1;POLR3D;PSMD4;POLR2K;TRAF5;YWHAG;HDAC4;IKBKB;PIK3CD

POLR2L has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2L itself. We selected most functions POLR2L had, and list some proteins which have the same functions with POLR2L. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	TBX1;SOX21B;EBF3A;HER3;ETV5;ZNF672;NR6A1;RX3;SS18L1
DNA-directed RNA polymerase activity	POLR3B;POLR2M;POLR2J;POLR3K;POLR3G;MED20;POLR2D;POLR1C;PRIM2
contributes_to RNA polymerase I activity	POLR2F;POLR2E;POLR1A;POLR2EB;POLR2L;POLR1C;POLR2K;POLR2H;POLR1E
contributes_to RNA polymerase II activity	POLR2C;POLR2B;POLR2K;POLR2H;POLR2A;POLR2E;POLR2EB;POLR2L;POLR2J2
contributes_to RNA polymerase III activity	POLR3F;POLR1C;CRCP;POLR3D;POLR3GLA;POLR2L;POLR3H;POLR2E;POLR3GLB
protein binding	AMFR;INHBB;RAB4A;NINJ1;ACHE;SYNJ2BP;RECQL4;CCDC110;HS3ST5
zinc ion binding	BRF1;LDB3;MICALL2;ARIH1;ADH7;ADAMTS16;IFIH1;BIRC3;AKT1S1

POLR2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2L here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2L.

ZBTB14; COIL; REL; TP53BP2; PHC2; BANP; L3MBTL3