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PON3

Official Full Name

paraoxonase 3
Overview

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Synonyms

PON3; paraoxonase 3; serum paraoxonase/lactonase 3; paraoxanase-3; arylesterase 3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Insect Cell
Insect Cells
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PON3-594H	Active Recombinant Human PON3 protein(Gly2~Leu354), His-tagged	E.coli	His	Gly2~Leu354	Inquiry
Human	PON3-27H	Recombinant Human PON3 protein, His-tagged	Insect Cells	His	Met1-Leu354,50Ser/Asn	Inquiry
Human	PON3-467HCL	Recombinant Human PON3 cell lysate	Insect Cell	N/A		Inquiry
Human	PON3-4954H	Recombinant Human PON3 Protein (Leu22-Leu354), N-His tagged	E.coli	N-His	Leu22-Leu354	Inquiry
Mouse	PON3-13123M	Recombinant Mouse PON3 Protein	Mammalian Cell	His		Inquiry
Mouse	PON3-6941M-B	Recombinant Mouse PON3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PON3-6941M	Recombinant Mouse PON3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PON3-4579R	Recombinant Rat PON3 Protein	Mammalian Cell	His		Inquiry
Rat	PON3-4239R-B	Recombinant Rat PON3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PON3-4239R	Recombinant Rat PON3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	PON3-3018Z	Recombinant Zebrafish PON3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PON3 Related Articles
PON3 Related Research Area

PON3 involved in several pathways and played different roles in them. We selected most pathways PON3 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PON3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolic pathways	PKMB;CCBL2;CBSA;SCLY;INPP4A;SMPD4;ETNK2;PLCB2;TALDO1

PON3 has several biochemical functions, for example, 3,4-dihydrocoumarin hydrolase activity, aryldialkylphosphatase activity, arylesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PON3 itself. We selected most functions PON3 had, and list some proteins which have the same functions with PON3. You can find most of the proteins on our site.

Function	Related Protein
3,4-dihydrocoumarin hydrolase activity	LIPN;DAGLB;Aadacl3;ABHD2B;Cel;CES1C;PNPLA7;NOTUM1A;PON3
aryldialkylphosphatase activity	PON1;PON3
arylesterase activity	C20orf3;CA1;CAR1;PON1;PON2;Car2;CA2;PON3;APMAP
dihydrocoumarin hydrolase activity
metal ion binding	RHEB;MARCH4;MYCBP2;ZBTB33;MLL5;MYLIPA;CYB561;CBFA2T2;C2
protein homodimerization activity	ERP29;PDCD6IP;USH1G;TIMM10;CAMK2B;ANXA9;SLC11A1;TSC2;AADAT

PON3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PON3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PON3.

q9wmx2-pro_0000037550; d-mannose

Rull, A; Garcia, R; et al. Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease. ATHEROSCLEROSIS 220:545-551(2012).

Garcia-Heredia, A; Marsillach, J; et al. Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease. CLINICAL BIOCHEMISTRY 44:1320-1324(2011).

Lipid and Fatty Acid Transport