PPARG
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Official Full Name
peroxisome proliferator-activated receptor gamma
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Overview
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] -
Synonyms
PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1;
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- Mammalian cells
- Yeast
- Flag
- GST
- His
- HIS
- His (Fc)
- Avi
- His|MBP
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PPARG Related Articles
- PPARG Related Research Area
PPARG involved in several pathways and played different roles in them. We selected most pathways PPARG participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PPAR signaling pathway | APOA1A;ACAA1;CYP8B1;ILK;FABP3;PPARDB;DBI;RXRB;SLC27A1A |
AMPK signaling pathway | TBC1D1;CAMKK1;FBP1;SIRT1;PFKP;CCNA1;ADIPOQ;IRS4;PPP2CA |
Osteoclast differentiation | IFNGR2;IFNGR1;LILRB1;IL1R1;PIK3CB;MAPK1;PLCG2;SOCS3;RAC1 |
Huntingtons disease | ITPR1;CREB3L2;NDUFB8;ATP5G1;HDAC1;NDUFS7;NDUFB5;DNAH11;BDNF |
Pathways in cancer | NFKB2;BMP4;GNG11;PTGER4;GLI2;HSP90AA1;SOS1;PDGFRB;WNT9B |
Transcriptional misregulation in cancer | PTK2;TRP53;HOXA9;ITGB7;IGF1R;PRCC;HOXA10;SFPI1;PPARG |
Thyroid cancer | RET;NTRK1;LEF1;RXRG;BRAF;KRAS;MAPK3;MAP2K1;MAPK1 |
PPARG has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARG itself. We selected most functions PPARG had, and list some proteins which have the same functions with PPARG. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF582;PURBB;POLRMT;ARHGEF38;DDIT3;ELF2A;MESP1;STAT1B;EXO1 |
RNA polymerase II regulatory region DNA binding | ATXN3L;NKX2-1;TXK;PPARG;NPAS4;NCOA1 |
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | RORA;NR2F6A;ESR2;RXRB;RORC;NR2F6;NR1I3;NR2F1A;PPARAB |
WW domain binding | TCEAL2;NFE2;TCEAL3;KIF20B;PMEPA1;TRP63;TCEAL6;WBP5;DNM2 |
activating transcription factor binding | PPARG;TAF9;DGKQ;ZFP516;MEF2C;MEF2A;EP300;PRDM16;MEF2D |
alpha-actinin binding | KCNA5;PPARG;XIRP2;ALMS1;ADORA2A;MYOT;LRRC10;MAGI1;KCNN2 |
arachidonic acid binding | S100A9;PPARG;CYP4F14;CYP4A14;ALOX5AP;STX3;S100A8 |
chromatin binding | SIN3A;PHF8;SOX14;NCOA2;ZEB1;ASF1A;HDGFRP2;BRD4;GATA3 |
core promoter sequence-specific DNA binding | CRY1;RORA;GATA3;THRAP3;NRF1;SOHLH1;NRIP1;NR4A3;TRP53 |
drug binding | IL2RA;CHRNA2;TYMS;DRD4;DRD1A;HMGB2;ADRB2;SMO;ABP1 |
enzyme binding | C2orf56;MDM2;PTPN1;PHKG1;ABCD1;ZFP36;RPA2;MSH3;HAND2 |
estrogen receptor binding | STRN;LEF1;XBP1;PHB2;MMS19;FUS;PADI2;TAF10;HSD17B10 |
ligand-dependent nuclear receptor transcription coactivator activity | SMARCD3;NCOA1;DCAF6;PPARGC1B;PRKCB;ZCCHC18;THRAP3;SRA1;ENY2 |
metal ion binding | OLA1;ZNF485;RPS6KAL;PDE6B;MGAT1;KMT2A;JADE3;MAP2K2;CIT |
protein binding | EYA2;TNF;LYRM2;ADRB3;ZNF295;PALLD;ZC3HAV1;MEI4;TRAM2 |
protein phosphatase binding | SNX3;HSF4;EIF2AK3;JAK1;JUP;VCAN;EGFR;GNB2L1;TRAF2 |
retinoid X receptor binding | NR1H4;HMGA1;HMGA1-RS1;FUS;NR4A2;NRIP1;RARG;RARB;MED25 |
contributes_to sequence-specific DNA binding | NEUROD1;HIF1A;ARNT;SMAD4;TRIM28;FIGLA;HNRNPAB;HDAC4;PPARG |
steroid hormone receptor activity | RXRG;NR2F1A;RXRB;PPARDB;NR2F1B;PPARAB;NR2F6B;RARA;RXRBB |
transcription factor activity, sequence-specific DNA binding | SLC12A9;OTX1A;PPARG;ZHX2;SOX13;ZNF397;ARID4A;POU2F1B;POU3F2A |
transcription factor binding | IFI203;HDAC7;NFATC2;NR0B2;ZFPM2;PELP1;MECP2;SOX8;RBFOX2 |
transcription regulatory region DNA binding | ZNF335;TFE3;PRDM5;CBX4;SMAD6;HINFP;WNT1;KDM1A;GLIS2 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | HIF1A;STAG2;AIRE;HOXD8;PPARG;SOX17;GLIS1;OVOL2;ZGLP1 |
zinc ion binding | TRPS1;SEC23A;GFI1AA;PIAS3;TRIM14;L3MBTL4;CPB2;TXNDC17;ALKBH8 |
PPARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARG here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARG.
Sirt1; MED1; SIRT1; Prdm16; ucp1_mouse_gene
- Q&As
- Reviews
Q&As (7)
Ask a questionPPARG has two isoforms, PPARG1 (57 kDa) and PPARG2, a splice variant with an additional 30 amino acids at the N-terminus.
PPARG has two isoforms with molecular weights of 57 kDa and 54 kDa. Modified PPARG is about 67 kDa.
PPARG stands for Peroxisome Proliferator-Activated Receptor Gamma.
Yes, experimental data suggests a 45 kDa protein immunologically related to PPARG, called mt-PPAR, is located in mitochondria. Its molecular weight is less than PPARG2.
PPARG is a ligand-activated transcription factor that plays a crucial role in regulating lipid homeostasis, adipogenesis, insulin resistance, and organ development.
Defects in PPARG are associated with familial partial lipodystrophy type 3 (FPLD3), susceptibility to obesity, type 2 insulin-resistant diabetes, hypertension, and colon cancer.
PPARG is mainly localized in the nucleus, although it can also be detected in the cytoplasm, exhibiting extra-nuclear/non-genomic actions in certain contexts.
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