ppat
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  • Official Full Name
  • phosphoribosyl pyrophosphate amidotransferase
  • Background
  • The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.
  • Synonyms
  • PPAT; phosphoribosyl pyrophosphate amidotransferase; amidophosphoribosyltransferase; GPAT; PRAT; Amidophosphoribosyltransferase [Precursor]; ATASE; Glutamine phosphoribosylpyrophosphate amidotransferase; Glutamine PRPP amidotransferase; glutamine phosphoribosylpyrophosphatate amidotransferase
Cat.#:PPAT-1874HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPAT, His-tagged
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Cat.#:Ppat-3408RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ppat, His-tagged
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Cat.#:PPAT-4596RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPAT Protein
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Cat.#:PPAT-3538RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPAT Protein, His-tagged
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Cat.#:PPAT-1219CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPAT
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Cat.#:PPAT-5263ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPAT
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Cat.#:PPAT-2983HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPAT 293 Cell Lysate
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Cat.#:ppa-3594ETag:His
Source (Host):E. coliSpecies:E.coli
Product nameRecombinant E.coli ppa, His-tagged
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Involved Pathway

PPAT involved in several pathways and played different roles in them. We selected most pathways PPAT participated on our site, such as Purine metabolism, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPAT were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
ADAL; PDE4B; PKMB; NT5E; Adcy4; POLR2I; CANT1A; URAH; ADKB; POLE2
Alanine, aspartate and glutamate metabolism
AGXTA; GLULA; ADSSL; GLUD1; GLUD1A; ASS1; GLSA; GLS; GAD1B; GPT2
Metabolic pathways
GPAM; NDUFA7; EPRS; GALNT11; NMNAT2; ALG13; CDO1; PRPS1; LCT; PRODH

Protein Function

PPAT has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, amidophosphoribosyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPAT itself. We selected most functions PPAT had, and list some proteins which have the same functions with PPAT. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein RTEL1; ACO2; ERCC2; MOCS1; CDKAL1; ETFDH; LIAS; PRIM2; NDUFS7; NUBPL
Function amidophosphoribosyltransferase activity
Related Protein PPAT
Function metal ion binding
Related Protein SIRT4; SMAD2; CHN1; PPTC7A; CYP21A1; ZSCAN16; PRDM13; Scd2; NR2F1B; EXO5

Interacting Protein

PPAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPAT here. Most of them are supplied by our site. Hope this information will be useful for your research of PPAT.
ATXN1; EPT1