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PPP1R17

Official Full Name

protein phosphatase 1, regulatory subunit 17
Overview

The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

chromosome 7 open reading frame 16; GSBS; G-substrate; OTTHUMP00000158793; OTTHUMP00000202600;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPP1R17-0134H	Recombinant Human PPP1R17 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	PPP1R17-7974HCL	Recombinant Human C7orf16 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PPP1R17-3675H	Recombinant Human PPP1R17 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	PPP1R17-3433HF	Recombinant Full Length Human PPP1R17 Protein, GST-tagged	In Vitro Cell Free System	GST	155 amino acids	Inquiry
Mouse	PPP1R17-13226M	Recombinant Mouse PPP1R17 Protein	Mammalian Cell	His		Inquiry
Mouse	PPP1R17-7011M	Recombinant Mouse PPP1R17 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Ppp1r17-5067M	Recombinant Mouse Ppp1r17 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	PPP1R17-7011M-B	Recombinant Mouse PPP1R17 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
PPP1R17 Related Articles

PPP1R17 involved in several pathways and played different roles in them. We selected most pathways PPP1R17 participated on our site, such as Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Long-term depression	HRAS;BRAF;GNAZ;RAF1;PLCB3;MAP2K2;PRKCB;PRKG1;GRM1

PPP1R17 has several biochemical functions, for example, protein serine/threonine phosphatase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R17 itself. We selected most functions PPP1R17 had, and list some proteins which have the same functions with PPP1R17. You can find most of the proteins on our site.

Function	Related Protein
protein serine/threonine phosphatase inhibitor activity	PPP1R1C;PPP1R8;PPP1R14C;PPP1R1A;PPP1R11;PPP1R17

PPP1R17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R17 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R17.

Iizuka, M; Murata, T; et al. Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 300:G1010-G1021(2011).

Murthy, KS; Zhou, HP; et al. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via G(i3), Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. BIOCHEMICAL JOURNAL 374:145-155(2003).