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PPP2R1B

  • Official Full Name

    protein phosphatase 2, regulatory subunit A, beta

  • Overview

    This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.
  • Synonyms

    PPP2R1B; protein phosphatase 2, regulatory subunit A, beta; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A A beta; PP2A Abeta; PR65B; protein phosphatase 2A; regulatory subunit A; beta isoform; 2AAB_HUMAN; beta isoform of regulatory subunit A, protein phosphatase 2; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta; PP2A, subunit A, PR65 beta isoform; PP2A, subunit A, R1 beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta isoform; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A, beta isoform; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta isoform; PP2A, subunit A, R1-beta isoform; PP2A, subunit A, PR65-beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta; PP2A-Abeta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPP2R1B-27569TH Recombinant Human PPP2R1B Wheat Germ N/A 601 amino acids
Human PPP2R1B-1915H Recombinant Human PPP2R1B, GST-tagged E.coli GST C-term-348aa
Human PPP2R1B-2925HCL Recombinant Human PPP2R1B 293 Cell Lysate HEK293 N/A
Human PPP2R1B-414HF Recombinant Full Length Human PPP2R1B Protein In Vitro Cell Free System 601 amino acids
Rat PPP2R1B-4633R Recombinant Rat PPP2R1B Protein Mammalian Cell His
Rat PPP2R1B-4292R Recombinant Rat PPP2R1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPP2R1B-4292R-B Recombinant Rat PPP2R1B Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PPP2R1B-1432Z Recombinant Zebrafish PPP2R1B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PPP2R1B involved in several pathways and played different roles in them. We selected most pathways PPP2R1B participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwayWDR33;NXF2;PPP2CA;SMG1;PPP2R3C;PABPC1B;PABPC3;PPP2R2B;RNGTT
Sphingolipid signaling pathwayS1PR4;PIK3CA;SPTLC2;NOS3;ASAH2;PPP2R1B;PPP2CB;SGPP1;KRAS
Oocyte meiosisCAMK2A;MAPK3;MAPK1;IGF1R;YWHAQA;RPS6KA3;PPP3CB;INS;CPEB2
PIK-Akt signaling pathwayPPP2R5E;GNG13;PPP2R1A;FGFR2;RAC1;PIK3R3;PRL;LAMA1;FGF10
AMPK signaling pathwayPPP2R3A;PRKAA2;TBC1D1;RAB2A;PFKM;SLC2A4;INS;HMGCR;PRKAG1
Adrenergic signaling in cardiomyocytesAGTR1B;CALM3;ATP1A1;MAPK14;CACNB2;ATP1A1A.1;PPP2R5C;PRKACBB;CAMK2A
TGF-beta signaling pathwayTGFB3;ZFYVE16;TGFBR2;BAMBI;LEFTY1;SMAD4;CHD;BMPR2;RBX1
Hippo signaling pathwayTEAD2;WNT10B;GDF6;YWHAH;SMAD1;PRKCZ;ID1;SMAD4;WNT3A
Tight junctionMYL2B;PARD6B;PTEN;MYL12.1;EPB41L3A;LLGL2;PPP2R2CA;JAM3;SHROOM4
Dopaminergic synapseGNG4;PLCB2;CALM3;SLC18A1;DDC;CREB3;GNG8;PRKACA;PPP2R3A
Long-term depressionKRAS;PRKG2;GNAZ;GRIA1;PRKCG;PLA2G4C;PLCB2;GRM1;GUCY1B3
Chagas disease (American trypanosomiasis)IL12A;TLR6;SERPINE1;C1QA;CFLAR;TNFRSF1A;LOC100033925;PLCB4;PIK3R5
Hepatitis COAS1B;CLDN18;NFKB1;IRF7;MAPK12;PPP2R2A;CLDN14;IFNB1;IFIT1

PPP2R1B has several biochemical functions, for example, protein binding, protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R1B itself. We selected most functions PPP2R1B had, and list some proteins which have the same functions with PPP2R1B. You can find most of the proteins on our site.

Function Related Protein
protein bindingSENP5;EIF4G1;RRAGC;TOP2A;CALCOCO2;USH1G;SIX1;HIST1H2AL;UBE4A
protein phosphatase type 2A regulator activityPPP2R2CA;PPME1;PPP2R1A;IGBP1;ENSAA;SET;PPP2R5B;PPP2R2A;PPP2R5E

PPP2R1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R1B.

PPP2CA; STRN3; PPP2R5D; STRN; PPP2R5E

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