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PRKCH

  • Official Full Name

    protein kinase C, eta

  • Overview

    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
  • Synonyms

    PRKCH; protein kinase C, eta; protein kinase C eta type; PKC-L; nPKC-eta; protein kinase C-eta; MGC93383;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Strep
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKCH-19H Active Recombinant Human PRKCH protein, GST/His-tagged Insect Cell GST/His
Human PRKCH-8457H Active Recombinant Human PRKCH Sf9 Insect Cell N/A
Human PRKCH-196H Active Recombinant Human PRKCH(2-end) Protein, N-His-tagged Sf21 His 2-end
Human PRKCH-71H Recombinant Human PRKCH protein, Flag-tagged, Biotinylated Insect Cell Flag
Human PRKCH-18H Recombinant Human PRKCH protein, His-tagged E.coli His
Human PRKCH-28938TH Recombinant Human PRKCH N/A
Human PRKCH-403H Recombinant Human Protein Kinase C, Eta, GST-tagged, Active Sf9 Insect Cell GST
Human PRKCH-2855HCL Recombinant Human PRKCH 293 Cell Lysate HEK293 N/A
Human PRKCH-0196H Recombinant Human PRKCH Protein (S2-P683), GST tagged Insect Cell GST S2-P683
Human PRKCH-1571HF Active Recombinant Full Length Human PRKCH Protein, GST-tagged Insect (sf21) GST 1-683(end)
Human PRKCH-1440HF Active Recombinant Full Length Human PRKCH Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-683(end)
Human PRKCH-301284H Recombinant Human PRKCH protein, GST-tagged E.coli GST Arg634-Pro683
Human PRKCH-0197H Recombinant Human PRKCH Protein (M1-F204), His/Strep tagged E.coli His/Strep M1-F204
Mouse PRKCH-13367M Recombinant Mouse PRKCH Protein Mammalian Cell His
Mouse PRKCH-7096M Recombinant Mouse PRKCH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRKCH-7096M-B Recombinant Mouse PRKCH Protein Pre-coupled Magnetic Beads HEK293
Rat PRKCH-4681R Recombinant Rat PRKCH Protein Mammalian Cell His
Rat PRKCH-4340R Recombinant Rat PRKCH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRKCH-4340R-B Recombinant Rat PRKCH Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PRKCH involved in several pathways and played different roles in them. We selected most pathways PRKCH participated on our site, such as Vascular smooth muscle contraction, Tight junction, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Vascular smooth muscle contractionGNA12A;PRKCH;GNA11A;MYLK;ADCY1A;PRKCQ;GUCY1A3;PLA2G3;PPP1R12A
Tight junctionMYH6;VAPA;PPP2R2BB;PRKCHA;CLDN7A;GNAI2;HCLS1;SHROOM3;CLDN22
Inflammatory mediator regulation of TRP channelsCYP2C55;SRC;GNAS;BDKRB1;PRKCD;PRKCE;CYP2C38;ITPR3;CYP2C50

PRKCH has several biochemical functions, for example, ATP binding, Ral GTPase binding, calcium-independent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCH itself. We selected most functions PRKCH had, and list some proteins which have the same functions with PRKCH. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX20;PDGFRB;KIF6;ATP2B3A;CKMT2B;GUCY2C;AK2;HSP90AA1;ACTC1A
Ral GTPase bindingRNF41;USP33;MYO1C;RALBP1;LSM2;PRKCH;EXOC5;EXOC8;RAB34
calcium-independent protein kinase C activityPRKCD;PRKCE;PRKCH
enzyme bindingPARP4;NR5A1;CDK19;PRMT1;CAD;UGT1A3;HLCS;AKT1;PDE4DIP
metal ion bindingZFP36L2;ZNF711;UBA2;ATP9B;MARCH6;FLYWCH1;ZC3H11A;GLIS1;ATX1
protein kinase C activityPRKCG;PRKCH;PRKD1;PKN1;PRKCD;PRKCB;PRKCDA;PRKD2;PRKCHB

PRKCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCH here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCH.

ndb25_parsc; HSP90AB1; glpD; ZBTB8OS

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any ongoing clinical trials targeting PRKCH for therapeutic interventions? 11/19/2022

Yes, there are ongoing clinical trials exploring the potential of PRKCH as a therapeutic target in various diseases, including cancer and autoimmune disorders.

Is PRKCH protein involved in cardiovascular diseases, and how might it be targeted for therapeutic interventions? 10/27/2022

Yes, PRKCH has been implicated in cardiovascular diseases, and research is ongoing to explore its potential as a therapeutic target for conditions like hypertension and atherosclerosis.

Can PRKCH protein be a biomarker for certain diseases? 06/22/2019

Some studies suggest that altered levels of PRKCH could serve as a biomarker for certain diseases, aiding in early diagnosis and prognosis.

Are there any known genetic variations in the PRKCH gene associated with disease susceptibility? 06/09/2019

Genetic variations in the PRKCH gene have been investigated for their association with diseases, including autoimmune disorders and certain cancers.

In which clinical conditions is the expression of PRKCH protein dysregulated? 12/21/2018

Dysregulation of PRKCH has been observed in conditions such as autoimmune diseases, neurodegenerative disorders, and cardiovascular diseases.

Customer Reviews (3)

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Reviews
01/30/2023

    The high-quality PRKCH protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.

    11/18/2022

      PRKCH protein demonstrates great utility in protein electron microscopy structure analysis.

      04/03/2016

        In WB experiments, PRKCH protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.

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