PRKCQ
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Official Full Name
protein kinase C, theta
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Overview
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. -
Synonyms
PRKCQ; protein kinase C, theta; protein kinase C theta type; PRKCT; nPKC-theta; MGC126514; MGC141919;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect (sf21)
- Insect cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PRKCQ Related Articles
- PRKCQ Related Research Area
PRKCQ involved in several pathways and played different roles in them. We selected most pathways PRKCQ participated on our site, such as NF-kappa B signaling pathway, Vascular smooth muscle contraction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | BIRC2;GM10591;MAP3K14;LY96;Ccl21a;LBP;CCL4;DDX58;BCL10 |
| Vascular smooth muscle contraction | PRKCA;MAP2K2B;AVPR1A;MYL9A;MYH11;CALM;GNAQ;MAPK3;PPP1CAB |
| Tight junction | HRAS;CLDN15;LLGL2;CLDN8;CLDN15LA;RHOA;CLDNK;CLDN20;RHOAA |
| T cell receptor signaling pathway | CD3D;IL4;PTPN6;IKBKG;PPP3R2;VAV2;MAP3K7;SHB;GRAPA |
| Inflammatory mediator regulation of TRP channels | PIK3R3;PRKACA;BDKRB2;PRKCD;CAMK2G;PTGER2;TRPV2;MAPK8;PLCB3 |
| Adipocytokine signaling pathway | SLC2A1;POMC;ACSL1B;JAK2A;LEP;ACSL5;LEPB;PRKAB1A;ACACB |
| Insulin resistance | SREBF1;CREB5;G6PCA.2;PPP1CB;PTPRFB;PPARGC1A;RPS6KA2;G6PC2;TNFRSF1A |
| Measles | OAS1;IFNA4;TAB2;TACR1;IRF7;CCND2;TP53;IL2RG;CD3G |
PRKCQ has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCQ itself. We selected most functions PRKCQ had, and list some proteins which have the same functions with PRKCQ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KDR;GART;PIF1;PRKCH;ABCG2D;ABCB1;ABCF2;VPS4B;GATC |
| metal ion binding | ZNF83;HIC1L;PXNA;AKAP8L;COL1A1;CHSY3;RAD50;CYP8B2;Itga10&Itgb1 |
| protein binding | MGARP;GFI1B;ERRFI1;RPIA;KIFC3;PDLIM3;STAC;TRPC4;CSRNP1 |
| protein kinase C activity | PRKCE;PRKCHA;PKN3;PRKD3;PRKCG;PRKCI;PRKCZ;PKN2;PRKCBB |
| protein serine/threonine kinase activity | RPS6KA3A;PRKCDA;AKT1;STK3;CDK15;STK19;NIM1K;ROCK2A;AAK1 |
| ubiquitin-protein transferase activity | ZYG11B;MIB2;TRIM21;BIRC8;RNF20;FBXL21;ITCH;RNF144AA;CDC34 |
PRKCQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCQ here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCQ.
FYN; MAP4K3; N/A; GLRX3; PRKCZ
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