CARM1
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Official Full Name
coactivator-associated arginine methyltransferase 1
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Overview
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from;S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine;derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction,;metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)). -
Synonyms
CARM1; coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; PRMT4; protein arginine N-methyltransferase 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- Free Style 293-F Cell
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- Flag
- FLAG
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CARM1 Related Articles
CARM1 involved in several pathways and played different roles in them. We selected most pathways CARM1 participated on our site, such as Activation of gene expression by SREBF (SREBP), Androgen receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of gene expression by SREBF (SREBP) | SREBF2;PMVK;MTF1;DHCR7;HELZ2;NFYAL;CREBBP;NCOA2;CYP51A1 |
Androgen receptor signaling pathway | KAT5;RUNX2A;RHOB;ETV5A;TGFB1I1;PARK7;CMTM2A;AES;RNF14 |
BMAL1:CLOCK,NPAS2 activates circadian gene expression | HELZ2;CRY2;NCOA2;CARM1;CREBBP;CRY1;NRIP1;DBP;NAMPT |
Chromatin modifying enzymes | SMARCD1;PADI6;MBD3;PBRM1;ELP4;BRPF1;KDM5BA;BRPF3;KDM2A |
Chromatin organization | ARID1A;SMARCB1B;ELP4;JMJD6;WDR77;SUDS3;CARM1;CAPNS2;MTA1 |
Circadian Clock | CRY1;HELZ2;NAMPT;RAI1;CARM1;NRIP1;DBP;CSNK1E;CPT1A |
Coregulation of Androgen receptor activity | TCF4;PAWR;PA2G4;TGFB1I1;TMF1;CARM1;KDM1A;MAK;KDM3A |
Developmental Biology | CDK19;DPYSL5A;TDGF1;ITGB3A;EFNA1A;DUSP1;COL6A1;BOC;EPHA10 |
CARM1 has several biochemical functions, for example, beta-catenin binding, histone methyltransferase activity, histone methyltransferase activity (H3-R17 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by CARM1 itself. We selected most functions CARM1 had, and list some proteins which have the same functions with CARM1. You can find most of the proteins on our site.
Function | Related Protein |
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beta-catenin binding | AXIN2;CDH24;BTRC;CTNNBIP1;SOX17;MED12L;SMAD3;SMAD7;APC |
histone methyltransferase activity | SUV39H1;PRDM13;PRMT2;PRMT1;EED;SUZ12;CARM1;EZH2;PRMT6 |
histone methyltransferase activity (H3-R17 specific) | |
histone-arginine N-methyltransferase activity | PRMT2;PRMT8;PRMT7;PRMT3;CARM1;PRMT6;PRMT5 |
ligand-dependent nuclear receptor transcription coactivator activity | ACTN1;SS18;KDM1A;CCDC62;PPRC1;PSMC3IP;TSG101;CCAR1;FGF2 |
lysine-acetylated histone binding | BRDT;MLL1;TAF1;PHIP;TRIM24;BRD9;BRD2;BAZ2A;BRD7 |
protein binding | NOL9;PRKACB;EFHA1;PSMD10;RAB4B;MSH5;TRIM40;ZCCHC12;TXNDC11 |
protein homodimerization activity | SMAD3;CRTAM;CCBL1;ODZ4;AXIN1;HMGCL;HOGA1;SEPHS1;EVLA |
protein methyltransferase activity | METTL23;RNMTL1A;HEMK1;FBLL1;PRDM11;PRMT1;METTL11A;TRMT10C;NTMT1 |
protein-arginine N-methyltransferase activity | NDUFAF5;CARM1;TRMT10C;FBXO11;PRMT8B;PRDM12;METTL7B;METTL21D;METTL8 |
protein-arginine omega-N asymmetric methyltransferase activity | PRMT8B;CARM1;PRMT7;PRMT2;PRMT6;PRMT8;PRMT3;PRMT1 |
transcription coactivator activity | GTF2F1;NFE2;ARID1A;PRMT2;CEBPA;RXRB;JUNBB;UBE2L3;SUB1 |
transcription regulatory region DNA binding | TAF2;FOXI1;REST;GABPB2;SFPQ;SOX5;KLF4;SALL2;SNCA |
CARM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARM1.
SMARCC1; CEBPB; CEBPB; NUDT21; DNAJA3; QKI; ORF; NRIP1; HNRNPK; UBE2I
- Q&As
- Reviews
Q&As (5)
Ask a questionCARM1 is involved in the DNA damage response by influencing the recruitment of repair factors to damaged sites. Its role in chromatin remodeling contributes to efficient DNA repair processes.
CARM1 contributes to epigenetic regulation by modifying histones, promoting chromatin accessibility, and influencing the differentiation of cells by regulating the expression of lineage-specific genes.
CARM1 methylates arginine residues in histones, transcription factors, and other regulatory proteins. This modification regulates chromatin dynamics, transcriptional activation, and mRNA splicing.
CARM1 acts as a coactivator by methylating histone and non-histone proteins, modulating chromatin structure, and influencing gene expression through its involvement in transcriptional regulation.
CARM1 collaborates with histone acetyltransferases and other methyltransferases to modulate chromatin structure and transcription. This interplay is crucial for the fine-tuning of gene expression.
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