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CARM1

  • Official Full Name

    coactivator-associated arginine methyltransferase 1

  • Overview

    Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from;S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine;derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction,;metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)).
  • Synonyms

    CARM1; coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; PRMT4; protein arginine N-methyltransferase 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • Free Style 293-F Cell
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CARM1-176H Recombinant Human CARM1 Protein, GST-tagged E.coli GST 2-608
Human CARM1-617H Recombinant Human CARM1, His-tagged Sf21 Insect Cell His
Human CARM1-999H Recombinant Human CARM1, Flag-tagged Sf9 Insect Cell His/GST
Human CARM1-0402H Recombinant Human CARM1 Protein, GST-Tagged Wheat Germ GST
Human CARM1-451H Recombinant Human CARM1 Free Style 293-F Cell N/A
Human CARM1-7846HCL Recombinant Human CARM1 293 Cell Lysate HEK293 N/A
Human CARM1-003H Recombinant Human CARM1 Protein, GST-tagged E.coli GST 2-608
Human CARM1-4776H Recombinant Human CARM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CARM1-503H-B Recombinant Human CARM1 Protein Pre-coupled Magnetic Beads HEK293
Human CARM1-098H Recombinant Human CARM1 Protein, GST-tagged E. coli GST 2-608
Human CARM1-1535HFL Recombinant Full Length Human CARM1 Protein, C-Flag-tagged Mammalian cells Flag
Human CARM1-503H Recombinant Human CARM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Carm1-23M Active Recombinant Mouse Carm1 Protein, FLAG-tagged Insect Cell FLAG
Mouse CARM1-2735M Recombinant Mouse CARM1 Protein Mammalian Cell His
Mouse CARM1-1232M Recombinant Mouse CARM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CARM1-1232M-B Recombinant Mouse CARM1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Carm1-1966M Recombinant Mouse Carm1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CARM1-1139R Recombinant Rat CARM1 Protein Mammalian Cell His
Rat CARM1-797R Recombinant Rat CARM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CARM1-797R-B Recombinant Rat CARM1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CARM1-1064Z Recombinant Zebrafish CARM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CARM1 Related Articles

CARM1 involved in several pathways and played different roles in them. We selected most pathways CARM1 participated on our site, such as Activation of gene expression by SREBF (SREBP), Androgen receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of gene expression by SREBF (SREBP)SREBF2;PMVK;MTF1;DHCR7;HELZ2;NFYAL;CREBBP;NCOA2;CYP51A1
Androgen receptor signaling pathwayKAT5;RUNX2A;RHOB;ETV5A;TGFB1I1;PARK7;CMTM2A;AES;RNF14
BMAL1:CLOCK,NPAS2 activates circadian gene expressionHELZ2;CRY2;NCOA2;CARM1;CREBBP;CRY1;NRIP1;DBP;NAMPT
Chromatin modifying enzymesSMARCD1;PADI6;MBD3;PBRM1;ELP4;BRPF1;KDM5BA;BRPF3;KDM2A
Chromatin organizationARID1A;SMARCB1B;ELP4;JMJD6;WDR77;SUDS3;CARM1;CAPNS2;MTA1
Circadian ClockCRY1;HELZ2;NAMPT;RAI1;CARM1;NRIP1;DBP;CSNK1E;CPT1A
Coregulation of Androgen receptor activityTCF4;PAWR;PA2G4;TGFB1I1;TMF1;CARM1;KDM1A;MAK;KDM3A
Developmental BiologyCDK19;DPYSL5A;TDGF1;ITGB3A;EFNA1A;DUSP1;COL6A1;BOC;EPHA10

CARM1 has several biochemical functions, for example, beta-catenin binding, histone methyltransferase activity, histone methyltransferase activity (H3-R17 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by CARM1 itself. We selected most functions CARM1 had, and list some proteins which have the same functions with CARM1. You can find most of the proteins on our site.

Function Related Protein
beta-catenin bindingAXIN2;CDH24;BTRC;CTNNBIP1;SOX17;MED12L;SMAD3;SMAD7;APC
histone methyltransferase activitySUV39H1;PRDM13;PRMT2;PRMT1;EED;SUZ12;CARM1;EZH2;PRMT6
histone methyltransferase activity (H3-R17 specific)
histone-arginine N-methyltransferase activityPRMT2;PRMT8;PRMT7;PRMT3;CARM1;PRMT6;PRMT5
ligand-dependent nuclear receptor transcription coactivator activityACTN1;SS18;KDM1A;CCDC62;PPRC1;PSMC3IP;TSG101;CCAR1;FGF2
lysine-acetylated histone bindingBRDT;MLL1;TAF1;PHIP;TRIM24;BRD9;BRD2;BAZ2A;BRD7
protein bindingNOL9;PRKACB;EFHA1;PSMD10;RAB4B;MSH5;TRIM40;ZCCHC12;TXNDC11
protein homodimerization activitySMAD3;CRTAM;CCBL1;ODZ4;AXIN1;HMGCL;HOGA1;SEPHS1;EVLA
protein methyltransferase activityMETTL23;RNMTL1A;HEMK1;FBLL1;PRDM11;PRMT1;METTL11A;TRMT10C;NTMT1
protein-arginine N-methyltransferase activityNDUFAF5;CARM1;TRMT10C;FBXO11;PRMT8B;PRDM12;METTL7B;METTL21D;METTL8
protein-arginine omega-N asymmetric methyltransferase activityPRMT8B;CARM1;PRMT7;PRMT2;PRMT6;PRMT8;PRMT3;PRMT1
transcription coactivator activityGTF2F1;NFE2;ARID1A;PRMT2;CEBPA;RXRB;JUNBB;UBE2L3;SUB1
transcription regulatory region DNA bindingTAF2;FOXI1;REST;GABPB2;SFPQ;SOX5;KLF4;SALL2;SNCA

CARM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARM1.

SMARCC1; CEBPB; CEBPB; NUDT21; DNAJA3; QKI; ORF; NRIP1; HNRNPK; UBE2I

Zeng, H; Wu, JC; et al. A TR-FRET-Based Functional Assay for Screening Activators of CARM1. CHEMBIOCHEM 14:827-835(2013).
Sakabe, K; Hart, GW; et al. O-GlcNAc Transferase Regulates Mitotic Chromatin Dynamics. JOURNAL OF BIOLOGICAL CHEMISTRY 285:34460-34468(2010).
  • Q&As
  • Reviews

Q&As (5)

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How does CARM1 contribute to the DNA damage response and repair mechanisms? 01/22/2022

CARM1 is involved in the DNA damage response by influencing the recruitment of repair factors to damaged sites. Its role in chromatin remodeling contributes to efficient DNA repair processes.

Discuss the role of CARM1 in epigenetic regulation and its impact on cellular differentiation. 10/09/2021

CARM1 contributes to epigenetic regulation by modifying histones, promoting chromatin accessibility, and influencing the differentiation of cells by regulating the expression of lineage-specific genes.

What are the specific substrates of CARM1, and how does its methylation activity impact cellular processes? 02/13/2020

CARM1 methylates arginine residues in histones, transcription factors, and other regulatory proteins. This modification regulates chromatin dynamics, transcriptional activation, and mRNA splicing.

How does CARM1 contribute to gene regulation at the molecular level? 06/27/2019

CARM1 acts as a coactivator by methylating histone and non-histone proteins, modulating chromatin structure, and influencing gene expression through its involvement in transcriptional regulation.

Explain the interplay between CARM1 and other chromatin-modifying enzymes in the regulation of gene expression. 04/08/2018

CARM1 collaborates with histone acetyltransferases and other methyltransferases to modulate chromatin structure and transcription. This interplay is crucial for the fine-tuning of gene expression.

Customer Reviews (3)

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Reviews
09/29/2021

    Expert advice from customer service ensured we made the right protein choice.

    03/12/2020

      Fast and reliable delivery made a significant impact on our project timelines.

      07/26/2018

        Seamless service experience—this product was a breeze to order and receive.

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