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PRPS1

  • Official Full Name

    phosphoribosyl pyrophosphate synthetase 1

  • Overview

    This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PRPS1; phosphoribosyl pyrophosphate synthetase 1; deafness, X linked 2, perceptive, congenital , DFN2; ribose-phosphate pyrophosphokinase 1; CMTX5; DFNX1; PRS I; ribose phosphate diphosphokinase 1; deafness 2, perceptive, congenital; ribose-phosphate diph;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRPS1-30999TH Recombinant Human PRPS1 N/A
Human PRPS1-494H Recombinant Human PRPS1, His-tagged E.coli His
Human PRPS1-2820HCL Recombinant Human PRPS1 293 Cell Lysate HEK293 N/A
Human PRPS1-3372H Recombinant Human PRPS1 protein, His-SUMO-tagged E.coli His-SUMO 2-318aa
Human PRPS1-5047H Recombinant Human PRPS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse PRPS1-13460M Recombinant Mouse PRPS1 Protein Mammalian Cell His
Mouse PRPS1-7150M Recombinant Mouse PRPS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Prps1-5152M Recombinant Mouse Prps1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PRPS1-7150M-B Recombinant Mouse PRPS1 Protein Pre-coupled Magnetic Beads HEK293
Rat PRPS1-4723R Recombinant Rat PRPS1 Protein Mammalian Cell His
Rat PRPS1-4382R Recombinant Rat PRPS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRPS1-4382R-B Recombinant Rat PRPS1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey PRPS1-814C Recombinant Cynomolgus PRPS1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PRPS1-557C-B Recombinant Cynomolgus Monkey PRPS1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey PRPS1-557C Recombinant Cynomolgus Monkey PRPS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRPS1-3626R Recombinant Rhesus monkey PRPS1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRPS1-3444R Recombinant Rhesus Macaque PRPS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRPS1-3444R-B Recombinant Rhesus Macaque PRPS1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRPS1 Related Articles

PRPS1 involved in several pathways and played different roles in them. We selected most pathways PRPS1 participated on our site, such as Pentose phosphate pathway, Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose phosphate pathwayPFKM;ALDOB;PFKMA;RPE;RBKS;TKTL2;PGD;PGM1;FBP1B
Purine metabolismGUCY1B3;AK5;NT5C;AK7B;POLA2;POLR3E;PDE4B;NME6;UOX
Metabolic pathwaysATP6V0A2;UQCRC2B;R05D11.9;CYP4A10;CMPK;B4GALT6;HK1;MGAT2;AGPAT6
Carbon metabolismACAT1;GPR19;FH1;ENO1A;PKM2;CAT;GAPDH;ENO1B;PFKL
Biosynthesis of amino acidsPSAT1;PRPS1B;TKT;THA1;RPE;PGAM1A;MTR;ACO1;ASS1

PRPS1 has several biochemical functions, for example, ADP binding, AMP binding, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPS1 itself. We selected most functions PRPS1 had, and list some proteins which have the same functions with PRPS1. You can find most of the proteins on our site.

Function Related Protein
ADP bindingACTA1;GLUD2;PRKAG2;ABCG1;ATP1A1;APAF1;GLUD1;ERN1;VCP
AMP bindingPRKAG1;ACSS2;PRPS1;PRPS2;CYB5R3;ACSS1;APRT;PYGL;PYGM
ATP bindingKIF20A;PRKAG1;SLC27A5;DDX50;CCT6B;BBS10;PLK2;DDX10;ATP2A2A
GDP bindingPRPS2;RAB14;RAB7L1;SRP54;RAB11B;RAB7;PCK1;RHOB;RAB2A
carbohydrate bindingMBL1;CDIPT;CLEC18B;Pla2r1;EMC7;CLEC1B;ZG16B;MAN2A1;GALNT5
kinase activityTAOK1;AKT1;LMTK3;MOB1BA;PDXKB;RPS6KA3A;FN3KRP;EPHA4A;PINK1
magnesium ion bindingCLYBL;NEK6;GCLC;PDXP;FAN1;STK11;PAPOLA;DOM3Z;PPM1A
protein bindingFAM13C;PRKX;TTC12;RPL23A;GMIP;KRT5;PRNP;TMEM171;C2orf88
protein homodimerization activityG6PD;NCR3;PRPS1L1;LRRK2;HSF2;ABCB9;AGR2;GIMAP7;CRYM
ribose phosphate diphosphokinase activityPRPS2;PRPS1A;PRPS1B;PRPSAP1;PRPS1;PRPS1L1

PRPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPS1.

PRPS2; PRPSAP1; SPG21; GORASP2; PRPSAP2; PRPSAP1; FBXO31

Al-Maawali, A; Dupuis, L; et al. Prenatal growth restriction, retinal dystrophy, diabetes insipidus and white matter disease: expanding the spectrum of PRPS1-related disorders. EUROPEAN JOURNAL OF HUMAN GENETICS 23:310-316(2015).
Fridman, A; Saha, A; et al. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. BIOCHEMICAL JOURNAL 454:91-99(2013).
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