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PRRX2

Official Full Name

paired related homeobox 2
Overview

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.
Synonyms

PRRX2; paired related homeobox 2; paired mesoderm homeobox protein 2; PMX2; PRX2; Paired related homeobox protein 2; Paired-related homeobox protein 2; Predicted NUP98/PRRX2 fusion protein; PRRX2_HUMAN; PRX 2; PRX-2; OTTHUMP00000022344; OTTHUMP00000245229; paired-like homeodomain protein PRX2;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PRRX2-1421HCL	Recombinant Human PRRX2 cell lysate		N/A		Inquiry
Chicken	PRRX2-5526C	Recombinant Chicken PRRX2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PRRX2 involved in several pathways and played different roles in them. We selected most pathways PRRX2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRRX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PRRX2 has several biochemical functions, for example, sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRRX2 itself. We selected most functions PRRX2 had, and list some proteins which have the same functions with PRRX2. You can find most of the proteins on our site.

Function	Related Protein
sequence-specific DNA binding	HSF4;RORB;HNF4G;MSXC;TFCP2;CAMTA1;FOXI1;FOXQ1A;MAFG
transcription factor activity, sequence-specific DNA binding	PPARAA;E2F4;TBX10;RARGB;ZNF354B;L3MBTL4;HOXC5A;NFE2L1;TSC22D3

PRRX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRRX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRRX2.