psenen
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  • Official Full Name
  • presenilin enhancer gamma secretase subunit
  • Background
  • Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimers disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • Synonyms
  • PSENEN; presenilin enhancer gamma secretase subunit; PEN2; PEN-2; MDS033; MSTP064; gamma-secretase subunit PEN-2; presenilin enhancer 2 homolog; hematopoietic stem/progenitor cells protein MDS033;
Cat.#:PSENEN-2005HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSENEN, GST-tagged
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Cat.#:PSENEN-13547MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PSENEN Protein
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Cat.#:PSENEN-4760RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PSENEN Protein
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Cat.#:PSENEN-3645RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PSENEN Protein, His-tagged
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Cat.#:PSENEN-11617ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSENEN
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Cat.#:PSENEN-2789HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSENEN 293 Cell Lysate
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