PSMC3
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Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 3
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Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. -
Synonyms
PSMC3; proteasome (prosome, macropain) 26S subunit, ATPase, 3; 26S protease regulatory subunit 6A; TBP 1; TBP1; 26S proteasome AAA-ATPase subunit RPT5; Human immunodeficiency virus tat transactivator binding protein 1; MGC8487; Proteasome (prosome macropain) 26S subunit ATPase 3; Proteasome 26S ATPase subunit 3; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; PRS6A_HUMAN; PSMC 3; Tat binding protein 1; TAT-binding protein 1; TBP-1; OTTHUMP00000236492; OTTHUMP00000236493; OTTHUMP00000236494; human immunodeficiency virus tat transact;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PSMC3 involved in several pathways and played different roles in them. We selected most pathways PSMC3 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD2;PSMA7;PSMB11;PSME2;PSMD1;PSMD4A;PSMA3;PSMC5;SHFM1 |
| Epstein-Barr virus infection | ICAM1;HSPA1A;PSMC4;EP300;HSPB2;NFKB2;PSMC1;PIK3CG;PSMC2 |
PSMC3 has several biochemical functions, for example, ATP binding, ATPase activity, TBP-class protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC3 itself. We selected most functions PSMC3 had, and list some proteins which have the same functions with PSMC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ITPKA;LARS2;P2RX8;PLK1;CPS1;ACSBG2;ADCK1;ALDH18A1;SRPK1B |
| ATPase activity | ABCB4;MLH1;DNAH11;ABCB1A;KIF4;ATAD1;KIF2A;EIF4A1A;KIFC3 |
| TBP-class protein binding | DR1;BRF1B;BRF1A;PSMC4;BRF1;CAND1;CAND2;HHEX;PSMC5 |
| proteasome-activating ATPase activity | PSMC6;PSMC1;PSMC1A;PSMC5;PSMC1B;PSMC4;PSMC2;PSMC3 |
| protein binding | PEBP1;PAGE5;RIT1;PNMA2;MT1X;GTF2A1L;CD274;PARD6B;PES1 |
| transcription coactivator activity | SIX3;SMARCA2;HSF2;TUBB3;STIL;BIRC2;CTNNB1;PER2;LPIN3 |
| transcription corepressor activity | ATF3;SKOR2;ZNF136;HDAC9;CITED2;ANKRD1;TBL1XR1;RLIM;BRD7 |
PSMC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC3.
PSMC6; PSMD9; UCHL5
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