Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

PTAFR

  • Official Full Name

    Platelet-Activating Factor Receptor

  • Overview

    PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling. Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain. In leukocyte cell populations the receptor is found on platelets, myocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor. Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells.
  • Synonyms

    PTAFR; platelet-activating factor receptor; PAFR; PAF-R; OTTHUMP00000004040; OTTHUMP00000004041; PAF Receptor;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Cavia porcellus (Guinea pig)
  • Goat
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTAFR-2731HCL Recombinant Human PTAFR 293 Cell Lysate HEK293 N/A
Human PTAFR-13HFL Recombinant Full Length Human PTAFR Protein Wheat Germ
Human PTAFR-1034HFL Recombinant Human PTAFR protein, His&Flag-tagged HEK293 His&Flag 1-342 aa
Human PTAFR-1035H Recombinant Human PTAFR Full Length Transmembrane protein (Nanodisc) HEK293 N/A
Mouse PTAFR-13618M Recombinant Mouse PTAFR Protein Mammalian Cell His
Mouse PTAFR-7239M-B Recombinant Mouse PTAFR Protein Pre-coupled Magnetic Beads HEK293
Mouse PTAFR-7239M Recombinant Mouse PTAFR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTAFR-4795R Recombinant Rat PTAFR Protein Mammalian Cell His
Rat PTAFR-4454R Recombinant Rat PTAFR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTAFR-4454R-B Recombinant Rat PTAFR Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL2737BF Recombinant Full Length Bovine Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Cavia porcellus (Guinea pig) RFL437CF Recombinant Full Length Guinea Pig Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Goat RFL20696CF Recombinant Full Length Goat Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Homo sapiens (Human) RFL34836HF Recombinant Full Length Human Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Macaca mulatta (Rhesus macaque) RFL2896MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-208)
Mus musculus (Mouse) RFL13838MF Recombinant Full Length Mouse Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-341)
Rattus norvegicus (Rat) RFL22408RF Recombinant Full Length Rat Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-341)
Sus scrofa (Pig) RFL18314SF Recombinant Full Length Pig Platelet-Activating Factor Receptor(Ptafr) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Kit-1484 PTAFR CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTAFR Related Articles
  • PTAFR Related Research Area

PTAFR involved in several pathways and played different roles in them. We selected most pathways PTAFR participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTAFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayHTR6;PLCD4;CALML3;CACNA1DA;ADRB2;GNA14;SPHK1;CACNA1H;PPP3CCB
Neuroactive ligand-receptor interactionTRY;P2RX3B;CHRNA2A;TAAR14I;TAAR8A;MTNR1BB;TACR2;TAAR9;KISS1RB
Staphylococcus aureus infectionDSG1C;FCGR2A;CFH;C1QA;FGG;HLA-DPB1;DSG1A;ITGAM;PLG

PTAFR has several biochemical functions, for example, G-protein coupled purinergic nucleotide receptor activity, G-protein coupled receptor activity, lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTAFR itself. We selected most functions PTAFR had, and list some proteins which have the same functions with PTAFR. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled purinergic nucleotide receptor activityP2RY13;P2RY11;P2RY8;P2RY4;P2RY6;P2RY1;P2RY14;GPR171;GPR34B
G-protein coupled receptor activityTACR3A;GRM6;MRGPRA8;OLFR998;TAS2R120;GPRC6A;F2RL1.2;SETD6;TAS2R130
lipopolysaccharide bindingP2RX7;BPIFC;TREM2;CATHL3;SCARB1;PSMB4;BPI;BPIFA2;RNASE7
lipopolysaccharide receptor activityTLR2;PTAFR;LY96;TLR4;SCARB1
phospholipid bindingANXA5;NBEAL2;APOA5;LRBA;PRKCI;PACSIN1A;MTAP1B;STAP1;PLA2G4C
platelet activating factor receptor activityPDGFRB;PDGFRL;PTAFR

PTAFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTAFR here. Most of them are supplied by our site. Hope this information will be useful for your research of PTAFR.

CALM1; GORAB; SPATA24; GTPBP3

Leoni, G; Gripentrog, J; et al. Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. JOURNAL OF LEUKOCYTE BIOLOGY 97:87-101(2015).
Yu, Y; Zhang, MX; et al. Transactivation of epidermal growth factor receptor through platelet- activating factor/receptor in ovarian cancer cells. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 33:-(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All PTAFR Products

Required fields are marked with *

My Review for All PTAFR Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends