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PTGER4

  • Official Full Name

    prostaglandin E receptor 4 (subtype EP4)

  • Overview

    The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
  • Synonyms

    PTGER4; prostaglandin E receptor 4 (subtype EP4); EP4; EP4R; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • Myc
  • DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGER4-2716HCL Recombinant Human PTGER4 293 Cell Lysate HEK293 N/A
Human PTGER4-3628H Recombinant Human PTGER4 protein, His-tagged E.coli His 333-488 aa
Human PTGER4-5572H Recombinant Human PTGER4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTGER4-1998H Recombinant Human PTGER4 Protein, His&GST-tagged E.coli N-His&GST Arg333-Ile488
Human PTGER4-0191H Recombinant Human PTGER4 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human PTGER4-1138HFL Recombinant Human PTGER4 protein, His&Flag-tagged HEK293 His&Flag 1-488 aa
Mouse Ptger4-5219M Recombinant Mouse Ptger4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTGER4-4809R Recombinant Rat PTGER4 Protein Mammalian Cell His
Rat PTGER4-4468R Recombinant Rat PTGER4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTGER4-4468R-B Recombinant Rat PTGER4 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL2372BF Recombinant Full Length Bovine Prostaglandin E2 Receptor Ep4 Subtype(Ptger4) Protein, His-Tagged E.coli expression system His Full Length (1-492)
Homo sapiens (Human) RFL7296HF Recombinant Full Length Human Prostaglandin E2 Receptor Ep4 Subtype(Ptger4) Protein, His-Tagged E.coli expression system His Full Length (1-488)
Mus musculus (Mouse) RFL23954MF Recombinant Full Length Mouse Prostaglandin E2 Receptor Ep4 Subtype(Ptger4) Protein, His-Tagged E.coli expression system His Full Length (1-513)
Oryctolagus cuniculus (Rabbit) RFL26880OF Recombinant Full Length Rabbit Prostaglandin E2 Receptor Ep4 Subtype(Ptger4) Protein, His-Tagged E.coli expression system His Full Length (1-488)
Pan troglodytes (Chimpanzee) RFL14528PF Recombinant Full Length Pan Troglodytes Prostaglandin E2 Receptor Ep4 Subtype(Ptger4) Protein, His-Tagged E.coli expression system His Full Length (1-490)
Rattus norvegicus (Rat) RFL33352RF Recombinant Full Length Rat Prostaglandin E2 Receptor Ep4 Subtype(Ptger4) Protein, His-Tagged E.coli expression system His Full Length (1-488)
Rhesus Macaque PTGER4-3690R Recombinant Rhesus monkey PTGER4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTGER4-3508R Recombinant Rhesus Macaque PTGER4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTGER4-3508R-B Recombinant Rhesus Macaque PTGER4 Protein Pre-coupled Magnetic Beads HEK293
Chicken PTGER4-3654C Recombinant Chicken PTGER4 Mammalian Cell His
Kit-0940 CYP2D6 Blue Screening Kit N/A
Kit-1489 PTGER4 HEK 293 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PTGER4 involved in several pathways and played different roles in them. We selected most pathways PTGER4 participated on our site, such as Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGER4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionLHCGR;IL12;AVPR2;PTGER4;GRID1;CALCR;MTNR1A;RXFP1;AGTR1B
Inflammatory mediator regulation of TRP channelsPLCB2;ALOX12;HTR2C;ITPR3;PRKCE;TRPV3;CYP4A14;HTR2A;CYP2C55
Renin secretionCLCA4;GNAS;AGTR1B;CLCA3;PLCB2;CALM1;ITPR1;LOC100328615;CALM4
Pathways in cancerPTGER3;IL-8;FOXO1;WNT3;GNAI1;HSP90AA1;ARHGEF12;PIAS2;PLCG1

PTGER4 has several biochemical functions, for example, prostaglandin E receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGER4 itself. We selected most functions PTGER4 had, and list some proteins which have the same functions with PTGER4. You can find most of the proteins on our site.

Function Related Protein
prostaglandin E receptor activityHPGD;PTGER4C;PTGER2A;PTGER4;PTGER3;PTGER2B;PTGER1A;PTGER2;PTGER1C
protein bindingGRIN2A;SEMA7A;SETD2;CDAN1;SNF8;KCNMB4;CPT1C;RAB3A;CLC

PTGER4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGER4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGER4.

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