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Official Full Name
protein tyrosine phosphatase, non-receptor type 14
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.
PTPN14; protein tyrosine phosphatase, non-receptor type 14; tyrosine-protein phosphatase non-receptor type 14; protein-tyrosine phosphatase PTP36; PTP36; C130080N23Rik; OTTMUSG00000022087