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PTPRC

  • Official Full Name

    protein tyrosine phosphatase, receptor type, C

  • Overview

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
  • Synonyms

    PTPRC; protein tyrosine phosphatase, receptor type, C; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Insect Cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Yeast
  • C
  • hFc
  • His
  • Avi
  • DDK|His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • His|GST
  • His|S
  • SUMO
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPRC-1522H Active Recombinant Human PTPRC, His-tagged Sf9 Insect Cell His 604 aa-end
Human PTPRC-43H Active Recombinant Human PTPRC(598-end) Protein, N-His-tagged E. coli His 598-end
Human PTPRC-133H Active Recombinant Human PTPRC Protein, His-tagged Mammalian cells His Gln24-Lys575
Human PTPRC-1262H Acitve Recombinant Human PTPRC protein(Met1-Lys416), hFc-tagged HEK293 C-hFc Met1-Lys416
Human PTPRC-4265H Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, C Human N/A
Human PTPRC-1622H Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, C, His-tagged Sf9 Insect Cell His
Human PTPRC-230H Recombinant Human PTPRC, Fc tagged Human Cell Fc
Human PTPRC-3046HCL Recombinant Human PTPRC cell lysate HEK293T Myc/DDK
Human PTPRC-480H Recombinant Human protein tyrosine phosphatase, receptor type, C, His-tagged E.coli His
Human PTPRC-232H Recombinant Human PTPRC, StrepII-tagged Human Cell Strep II 598-1304, 707 a.a.
Human PTPRC-468H Recombinant Human PTPRC, GST-tagged, Active E.coli GST
Human PTPRC-27135TH Recombinant Human PTPRC, His-tagged His
Human PTPRC-671H Recombinant Human PTPRC, His-tagged Sf9 Insect Cell His
Human PTPRC-231H Recombinant Human PTPRC, StrepII-tagged Human Cell Strep II 24-575, 552 a.a.
Human PTPRC-186H Recombinant Human PTPRC Protein, DDK/His-tagged HEK293 DDK/His Gln26-Lys577
Human PTPRC-3045HCL Recombinant Human PTPRC cell lysate Human Cell N/A
Human PTPRC-575H Recombinant Human PTPRC protein, His-tagged HEK293 His Gln26­Lys482
Human PTPRC-686H Recombinant Human PTPRC Protein, His-tagged HEK293F N-His Gln26-Lys463
Human PTPRC-576H Recombinant Human PTPRC protein, His-tagged HEK293 His Gln26­Lys416
Human PTPRC-655H Recombinant Human PTPRC Protein (Met1-Lys529), His-tagged HEK293 His Met1-Lys529
Human PTPRC-3392H Recombinant Human PTPRC protein, His-SUMO-tagged E.coli His-SUMO 24-575aa
Human PTPRC-5506H Recombinant Human PTPRC protein, His-tagged Yeast His 24-575aa
Human PTPRC-151H Recombinant Human PTPRC Protein, His-tagged Human cells His
Human PTPRC-730H Recombinant Human PTPRC Protein, His-tagged E.coli N-His Gln26-Lys463
Human PTPRC-2729HFL Recombinant Full Length Human PTPRC, Flag-tagged Mamanlian cells Flag
Human PTPRC-122H Recombinant Human PTPRC Protein, C-His-tagged E.coli C-His
Human PTPRC-577H Recombinant Human PTPRC(Gln26-­Lys577) Protein, C-6*His-tagged HEK293 His
Human PTPRC-3945H Recombinant Human PTPRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTPRC-442H Active Recombinant Human PTPRC Protein, Fc-tagged CHO Fc
Human PTPRC-2362H Recombinant Human PTPRC protein, His-tagged HEK293 His Gln26-Lys575
Human PTPRC-3253H Recombinant Human PTPRC protein, His-tagged E.coli His Gln26~Ser194
Human PTPRC-1447H Recombinant Human PTPRC Protein (Thr24-Asn575), N-His tagged E.coli N-His Thr24-Asn575
Human CDA089P Recombinant Human CD-45 E.coli N/A
Human PTPRC-5047H Recombinant Human PTPRC Protein (Met1-Lys575), C-His tagged Mammalian cells C-His Met1-Lys575
Human PTPRC-3945H-B Recombinant Human PTPRC Protein Pre-coupled Magnetic Beads HEK293
Human PTPRC-2599H Recombinant Human PTPRC protein(241-310 aa), C-His-tagged E. coli C-His 241-310 aa
Human PTPRC-1446H Recombinant Human PTPRC Protein (Gln26-Lys463), N-His tagged E.coli N-His Gln26-Lys463
Human PTPRC-5048H Recombinant Human PTPRC Protein (Gln26-Lys577), C-His tagged Mammalian cells C-His Gln26-Lys577
Human PTPRC-050H Recombinant Human PTPRC Protein, Gln26-Lys416, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Gln26-Lys416
Mouse Ptprc-550M Active Recombinant Mouse Ptprc protein(Arg453-Ser1152) Insect Cells N/A Arg453-Ser1152
Mouse Ptprc-684M Active Recombinant Mouse Ptprc, His-tagged Mammalian cells His
Mouse PTPRC-1314M Acitve Recombinant Mouse PTPRC protein(Arg453-Ser1152), His&GST-tagged Insect Cells N-His&GST Arg453-Ser1152
Mouse Ptprc-1623M Recombinant Mouse Protein Tyrosine Phosphatase, Receptor Type, C, GST-tagged E.coli GST
Mouse Ptprc-5759M Recombinant Mouse Ptprc protein, His & S-tagged E.coli His/S Asp371~Asn556 (Accession # P06800)
Mouse PTPRC-480M Recombinant Mouse Ptprc, DDDDK tagged Insect Cell Fc
Mouse Ptprc-8677M Recombinant Mouse Ptprc, His & GST tagged Insect Cell His/GST
Mouse PTPRC-1141MCL Recombinant Mouse PTPRC cell lysate Human Cell N/A
Mouse PTPRC-001MCL Recombinant Mouse PTPRC cell lysate Insect Cell N/A
Mouse Ptprc-551M Recombinant Mouse Ptprc(Gln26­-Lys566) Protein, C-6*His-tagged HEK293 His
Mouse Ptprc-7284M Recombinant Mouse Ptprc Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ptprc-7284M-B Recombinant Mouse Ptprc Protein Pre-coupled Magnetic Beads HEK293
Mouse Ptprc-4538MFL Recombinant Full Length Mouse Ptprc, Flag-tagged Mamanlian cells Flag
Mouse PTPRC-2172M Active Recombinant Mouse PTPRC protein, hFc-tagged HEK293 hFc Met1-Leu429
Rat PTPRC-4838R Recombinant Rat PTPRC Protein Mammalian Cell His
Rat PTPRC-4497R Recombinant Rat PTPRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ptprc-1203R Recombinant Rat Ptprc Protein, His-tagged E.coli N-His Asp357-Ala547
Rat PTPRC-4497R-B Recombinant Rat PTPRC Protein Pre-coupled Magnetic Beads HEK293
Chicken PTPRC-5987C Recombinant Chicken PTPRC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPRC Related Articles

PTPRC involved in several pathways and played different roles in them. We selected most pathways PTPRC participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CD86;CD22;MHC2A;VTCN1;HLA-DRB3;CLDN3;NLGN2;CDH2;NFASCA
T cell receptor signaling pathwayEVLB;CBLC;VAV3;NRAS;PAK7;MAPK12;ICOS;BCL10;CD8B1
Fc gamma R-mediated phagocytosisAKT1;PLA2G6;GSN;LYN;PIK3R5;MYO10;LIMK1;DOCK2;LAT
Primary iCD3D;CD3E;CD19;CD8B;RAG2;CD8B1;TNFRSF13B;ZAP70;TAP2
nodeficiencyCD8B1;RFX5;TNFRSF13B;DCLRE1C;RFXAP;LCK;CD8B;RAG1;ORAI1

PTPRC has several biochemical functions, for example, protein binding, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRC itself. We selected most functions PTPRC had, and list some proteins which have the same functions with PTPRC. You can find most of the proteins on our site.

Function Related Protein
protein bindingMC5R;EHD4;CRTAC1;SPG21;ARHGEF40;GATAD2A;ALKBH4;HNRNPR;LCOR
protein kinase bindingSLC12A5;MAP2K7;MVP;MAML1;HNRNPA0;CDKN2A;DCX;MAP3K1;SREBF1
protein tyrosine phosphatase activityPTPDC1;DUSP28;TPTE;DUSP19;DUSP26;PGP;PTPN1;SSH1;PTPRJ
transmembrane receptor protein tyrosine phosphatase activityPTPRA;PTPN6;PTPRUB;PTPRN2;PTPRO;PTPRM;PTPRE;PTPRR;PTPRD

PTPRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRC here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRC.

LCK; CSK; CTNNB1; LGALS1; ITGAL; PDPK1; EGFR; ERBB2

Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).
Aspinall-O'Dea, M; Pierce, A; et al. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. NATURE PROTOCOLS 10:149-168(2015).
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