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PTPRU

Official Full Name

protein tyrosine phosphatase, receptor type, U
Overview

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.
Synonyms

PTPRU; protein tyrosine phosphatase, receptor type, U; receptor-type tyrosine-protein phosphatase U; FMI; hPTP J; PCP 2; pi R PTP Psi; PTP; PTPRO; PTP pi; pi R-PTP-Psi; protein tyrosine phosphatase J; protein-tyrosine phosphatase J; protein-tyrosine phosp;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PTPRU-8108H	Recombinant Human PTPRU protein, His & T7-tagged	E.coli	His/T7	Arg1263~Arg1446 (Accession # Q92729)	Inquiry
Human	PTPRU-5511H	Recombinant Human PTPRU Protein (Arg1263-Arg1446), N-His tagged	E.coli	N-His	Arg1263-Arg1446	Inquiry
Mouse	PTPRU-13709M	Recombinant Mouse PTPRU Protein	Mammalian Cell	His		Inquiry
Mouse	PTPRU-7292M-B	Recombinant Mouse PTPRU Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PTPRU-7292M	Recombinant Mouse PTPRU Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	PTPRU-6062C	Recombinant Chicken PTPRU	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PTPRU Related Gene Family
PTPRU Related Research Area

PTPRU involved in several pathways and played different roles in them. We selected most pathways PTPRU participated on our site, such as EPO Receptor Signaling, Kit Receptor Signaling Pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
EPO Receptor Signaling	CISH;PTPRU;PTPRUB
Kit Receptor Signaling Pathway	DOK1;STAP1;SOCS4;DOK1B;PTPRU;GRB10;PTPRUB;GRAP;SPRED2B
Signal Transduction	ADH8B;OPHN1;USP2;USP9;CDC42EP2;NPS;ARHGAP29B;RAMP3;CRHB
Signaling by SCF-KIT	SH2B3;PTPRUB;PTPRU;GRAP

PTPRU has several biochemical functions, for example, beta-catenin binding, hydrolase activity, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRU itself. We selected most functions PTPRU had, and list some proteins which have the same functions with PTPRU. You can find most of the proteins on our site.

Function	Related Protein
beta-catenin binding	CTNNBIP1;BCL9;RORA;TBL1X;CDH24;DACT1;CDH1;PROP1;TRPC4
hydrolase activity	PARLA;MMP23BB;GGT7;GLS;REN2;LACTB2;BPHL;MEST;PRSS42
phosphatase activity	PTPRDB;PTPN23A;CTDSPLB;PTPRK;SACM1LB;ALPI.2;CAR3;CDC14A;PTPRJA
phosphoprotein phosphatase activity	PTPN11A;PPP2CA;PPM1NB;CDC14A;CTDNEP1;PTPRFB;DUSP16;PPM1AA;SSH1
protein tyrosine phosphatase activity	PTPRQ;PTPN11;PTPN23A;CDC25D;DUSP13;PTPRZ1;PTPRR;PTPRO;PTPN7

PTPRU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRU here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRU.

Phosphatases and Regulators