PDCD4
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Official Full Name
programmed cell death 4 (neoplastic transformation inhibitor)
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Overview
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] -
Synonyms
PDCD4; programmed cell death 4 (neoplastic transformation inhibitor); H731; programmed cell death protein 4; protein 197/15a; nuclear antigen H731; neoplastic transformation inhibitor protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Rabbit
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PDCD4 Related Research Area
- PDCD4 Related Signal Pathway
PDCD4 involved in several pathways and played different roles in them. We selected most pathways PDCD4 participated on our site, such as Proteoglycans in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Proteoglycans in cancer | ESR1;WNT5A;PIK3R2;FASLG;MMP9;CAMK2G;PRKCB;PRKACG;MAPK1 |
MicroRNAs in cancer | RECK;RASSF1;PRKCG;SLC45A3;PRKCA;HMOX1;Abcb1b;HOXD10;CCNE1 |
PDCD4 has several biochemical functions, for example, RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD4 itself. We selected most functions PDCD4 had, and list some proteins which have the same functions with PDCD4. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | RPL19;DDX19A;RNASEN;XPO5;SUPV3L1;FARSB;PTBP2A;HNRPL;CAPRIN2 |
protein binding | HDAC3;ABCF1;RNPS1;NOG;SORCS1;ZNF670;SDCBP;PIH1D3;PTPN1 |
PDCD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD4.
EIF4A2; EIF4A1; RELA; EIF4A3; RPS13
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, PDCD4 is involved in the regulation of NF-κB signaling pathway and other biological processes of sequencing signals, and can be a target for sequencing signals.
Immunodeficiency method, Western blot, fluorescence microscopy and other techniques can be used to evaluate the changes in the expression and function of PDCD4.
It may be involved in processes such as proliferation, apoptosis, and inflammatory response of intestinal epithelial cells, and is associated with intestinal diseases.
PDCD4 may be related to neuronal apoptosis, neuroinflammatory response, etc. in neurological diseases.
PDCD4 is involved in the regulation of hepatocyte growth, apoptosis and transformation, and may play a role in the occurrence and development of liver diseases.
Through in-depth study of the signaling pathways and regulatory mechanisms of PDCD4, we can provide important clues for the development of therapeutic strategies for related diseases.
Customer Reviews (3)
Write a reviewGood solubility and stability in solution.
The purity is good, and the results obtained after analysis by SDS-PAGE or Western blot are good.
Short half-life and high clearance.
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