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PDPN

  • Official Full Name

    Podoplanin

  • Overview

    This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    T1A; GP36; GP40; Gp38; OTS8; T1A-2; AGGRUS; HT1A-1; PA2.26; PDPN; podoplanin; T1-alpha; hT1alpha-1; hT1alpha-2; PA2.26 antigen; glycoprotein 36; OTTHUMP00000009639; OTTHUMP00000009640; OTTHUMP00000221492; OTTHUMP00000221493; OTTHUMP00000221495; OTTHUMP00000221496; OTTHUMP00000221498; OTTHUMP00000221499; glycoprotein, 36-KD; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • hFc
  • His
  • Fc
  • Avi
  • FC
  • GST
  • His (Fc)
  • His|GST
  • N/A
  • N
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDPN-2320H Active Recombinant Human PDPN, Fc-His tagged HEK293 FC/His Met1-Lys123
Human PDPN-571H Active Recombinant Human PDPN Protein, Fc Chimera Mammalian cells Fc
Human PDPN-2321H Active Recombinant Human PDPN protein, His-tagged HEK293 His Met1-Lys123
Human PDPN-31033TH Recombinant Human PDPN, His-tagged E.coli His
Human PDPN-28603TH Recombinant Human PDPN, His-tagged E.coli His 109 amino acids
Human PDPN-379H Recombinant Human Podoplanin, His-tagged E.coli His
Human PDPN-956H Recombinant Human Podoplanin (Fragment) E.coli N/A
Human PDPN-2517HCL Recombinant Human PDPN cell lysate Human Cell N/A
Human PDPN-42H Recombinant Human PDPN Protein, Fc/Avi-tagged HEK293 Fc/Avi
Human PDPN-1895H Active Recombinant Human PDPN protein, His-tagged HEK293 His Ala 23 - Leu 131
Human PDPN-301248H Recombinant Human PDPN protein, GST-tagged E.coli GST Ala99-Leu207
Human PDPN-133H-B Recombinant Human PDPN Protein Pre-coupled Magnetic Beads HEK293
Human PDPN-133H Recombinant Human PDPN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDPN-1897H Active Recombinant Human PDPN protein, Fc-tagged HEK293 Fc Ala 23 - Leu 131
Human PDPN-2706H Active Recombinant Human PDPN protein, hFc&His-tagged HEK293 hFc&His Glu97–Lys199
Human PDPN-3915H Recombinant Human PDPN Protein (Ala23-Leu131), C-His tagged Mammalian cells C-His Ala23-Leu131
Human PDPN-3917H Recombinant Human PDPN Protein (Ala23-Pro238), His tagged E.coli His Ala23-Pro238
Human PDPN-3918H Recombinant Human PDPN Protein (Ala23-Gly146), N-His tagged E.coli N-His Ala23-Gly146
Mouse Pdpn-8027M Recombinant Mouse Pdpn protein, His & GST-tagged E.coli His/GST Gly23~Val138 (Accession # Q62011)
Mouse PDPN-855M Active Recombinant Mouse PDPN protein, His-tagged Insect Cells His Met1-Lys133
Mouse Pdpn-832M Active Recombinant Mouse Pdpn protein, His&hFc-tagged HEK293 His&hFc Met1-Leu141
Mouse PDPN-2687MCL Recombinant Mouse PDPN cell lysate Human Cell N/A
Mouse PDPN-470MCL Recombinant Mouse PDPN cell lysate Insect Cell N/A
Mouse Pdpn-7215M Recombinant Mouse Pdpn Protein E.coli
Rat PDPN-4358R Recombinant Rat PDPN Protein Mammalian Cell His
Rat Pdpn-1149R Active Recombinant Rat Pdpn protein(Met1-Leu135), hFc-tagged HEK293 C-hFc Met1-Leu135
Rat PDPN-4018R Recombinant Rat PDPN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PDPN-4018R-B Recombinant Rat PDPN Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL36442CF Recombinant Full Length Dog Podoplanin(Pdpn) Protein, Tag-Free E.coli expression system Tag-Free Full Length of Mature Protein (23-169)
Homo sapiens (Human) RFL7986HF Recombinant Full Length Human Podoplanin(Pdpn) Protein, Tag-Free E.coli expression system Tag-Free Full Length of Mature Protein (23-162)
Mus musculus (Mouse) RFL9698MF Recombinant Full Length Mouse Podoplanin(Pdpn) Protein, Tag-Free E.coli expression system Tag-Free Full Length of Mature Protein (23-172 )
Rattus norvegicus (Rat) RFL25405RF Recombinant Full Length Rat Podoplanin(Pdpn) Protein, Tag-Free E.coli expression system Tag-Free Full Length of Mature Protein (23-166)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDPN Related Articles
  • PDPN Related Research Area

PDPN involved in several pathways and played different roles in them. We selected most pathways PDPN participated on our site, such as GPVI-mediated activation cascade, Hemostasis, Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
GPVI-mediated activation cascadeC6orf25;RHOGA;PIK3R6;PDPN;CLEC1B;RHOB;FCER1GL;G6b;LCP2A
HemostasisDGKG;HBBE1.1;PHF21A;PRTN3;KIFC1;RHOB;F9B;KIF15;HBG2
Platelet activation, signaling and aggregationSERPINF2B;MMRN1;FCER1GL;ABHD12;CD9B;PLEK;MMRN2A;STXBP3;IGF2B

PDPN has several biochemical functions, for example, NOT amino acid transmembrane transporter activity, NOT folic acid transporter activity, NOT water channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPN itself. We selected most functions PDPN had, and list some proteins which have the same functions with PDPN. You can find most of the proteins on our site.

Function Related Protein
NOT amino acid transmembrane transporter activity
NOT folic acid transporter activity
NOT water channel activityPDPN;MIPB
NOT water transmembrane transporter activity

PDPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPN here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPN.

TOM1L1

Li, JC; Li, Y; et al. Podoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion. MOLECULAR MEDICINE REPORTS 10:1513-1518(2014).
Kato, Y; Kaneko, MK; et al. A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin. SCIENTIFIC REPORTS 4:-(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does PDPN play in cancer progression, particularly in terms of tumor cell migration and metastasis? 07/24/2022

PDPN facilitates cancer progression by promoting tumor cell migration and enhancing metastatic potential.

How does PDPN contribute to the development and maintenance of lymphatic vessels? 05/20/2022

PDPN is crucial for lymphatic vessel development and maintenance, aiding in lymphatic system function.

How does the alteration of PDPN expression impact the pathogenesis of diseases like fibrosis and lymphedema? 03/17/2021

Changes in PDPN expression contribute to fibrosis and lymphedema pathogenesis, affecting tissue structure and fluid balance.

What is the significance of PDPN in the formation and stability of blood-lymphatic vessel junctions? 07/31/2020

PDPN is significant in forming and stabilizing blood-lymphatic vessel junctions, ensuring proper vascular function.

What are the mechanisms by which PDPN modulates platelet aggregation and blood coagulation? 04/14/2020

PDPN affects platelet aggregation and blood coagulation, playing a role in thrombosis and hemostasis.

How does PDPN expression affect the interaction between tumor cells and the immune system? 02/15/2019

PDPN expression on tumor cells alters their interaction with the immune system, impacting immune evasion.

How does PDPN influence wound healing and tissue regeneration processes? 04/10/2018

PDPN plays a role in wound healing and tissue regeneration, influencing cell migration and tissue repair.

Customer Reviews (3)

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Reviews
01/31/2021

    Swift protein expression optimization support; greatly appreciated.

    08/19/2019

      Accurate protein structural characterization; indispensable for our research.

      12/19/2018

        Reliable mass spectrometry analysis; pivotal for proteomics experiments.

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