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PIAS3

Official Full Name

protein inhibitor of activated STAT, 3
Overview

This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of;transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like;modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It;directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced;transcript variants of this gene have been identified, but the full-length nature of some of these variants has not;been determined.
Synonyms

PIAS3; protein inhibitor of activated STAT, 3; E3 SUMO-protein ligase PIAS3; FLJ14651; zinc finger; MIZ type containing 5; ZMIZ5; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|GST
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PIAS3-1704H	Recombinant Human PIAS3, GST-tagged	E.coli	GST	277-628aa	$319 / 25ug
Human	PIAS3-1245H	Recombinant Human PIAS3 protein, His & GST-tagged	E.coli	His/GST	Val11~Leu280 (Accession # Q9Y6X2)	Inquiry
Human	PIAS3-3202HCL	Recombinant Human PIAS3 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	PIAS3-12770M	Recombinant Mouse PIAS3 Protein	Mammalian Cell	His		Inquiry
Mouse	PIAS3-6719M-B	Recombinant Mouse PIAS3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PIAS3-6719M	Recombinant Mouse PIAS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PIAS3-4443R	Recombinant Rat PIAS3 Protein	Mammalian Cell	His		Inquiry
Rat	PIAS3-4103R-B	Recombinant Rat PIAS3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PIAS3-4103R	Recombinant Rat PIAS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PIAS3 Related Research Area
PIAS3 Related Signal Pathway

PIAS3 involved in several pathways and played different roles in them. We selected most pathways PIAS3 participated on our site, such as Androgen receptor signaling pathway, C-MYB transcription factor network, Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Androgen receptor signaling pathway	PSMC3IP;DAXX;POU2F1B;NCOA2;MYST2;SVILA;TGFB1I1;PATZ1;NR0B2A
C-MYB transcription factor network	CLTA;PPID;PTCRA;SMARCA2;COL1A2;CREBBP;ELANE;CDKN1B;CBX4
Coregulation of Androgen receptor activity	SVIL;ZMIZ1;PA2G4;CMTM2A;KDM4C;KDM1A;TGFB1I1;TCF4;CTDSP2
DNA Repair	ASCC1;RBBP8;ACTR5;TFPT;RAD51AP1;MCRS1;PPP4R2B;BRE;CLSPN
Formation of Incision Complex in GG-NER	PARP2;PIAS3;RNF111;USP45;CHD1L;DDB2;DDB1;CETN2
Global Genome Nucleotide Excision Repair (GG-NER)	COPS7B;MCRS1;COPS7A;TFPT;INO80C;INO80B;NFRKB;COPS4;ACTR5
IL6-mediated signaling events	LMO4;CRP;JUNB;PIAS3
Interferon type I	GNB2L1;PIAS3

PIAS3 has several biochemical functions, for example, SUMO transferase activity, enzyme binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS3 itself. We selected most functions PIAS3 had, and list some proteins which have the same functions with PIAS3. You can find most of the proteins on our site.

Function	Related Protein
SUMO transferase activity	UBE2I;UBE2IB;SUMO1;SUMO4;PIAS3;UBE2IA;TOPORS;PIAS4;MUL1
enzyme binding	MDM4;CASP2;ZFP346;PCCA;NOS1;TAL1;UGT1A1;BIRC5;HAND2
ligase activity	TRIM71;RNF182;MKRN1;RNF133;HECW2;RING1;RNF25;LRSAM1;PCXB
potassium channel regulator activity	LRRC26;DLG1;KCNAB2;NEDD4L;KCNMB2;KCNMB1;KCNMB4;KCNIP3;ANK2
protein C-terminus binding	NEFL;DYNLL1;MRE11A;VGLL1;RAD51;ARL6IP5;ATP2A2;TCF4;ID1
protein N-terminus binding	PARP1;PHB2;NIPBL;ARF6;SMARCE1;ID1;NCOA1;PEX5;KCNIP2
protein binding	LGALS1;TERF1;CKMT1;PRKCB;CLEC7A;MAPK4;COL6A5;ARRB1;MYO1C
zinc ion binding	YY1;MAN2B2;NR5A1;BTR22;RYBPA;VDRA;KNG1;CAR1;ADAM10B

PIAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS3.

MBD1; UBE2I; HNRNPK; GFI1; PRPF40A; SKIL; GLUL; UBA1; STAT3; yscQ; GEMIN4; PPP1CA; PSMC1; SATB1; CREM; SREBF2; q5ni67_fratt

Post-translational Modification of NFkB/IkB

Apoptosis Transcription Factors and Regulators

Ubiquitin-like Modifiers (UBLs) and Regulators