PIM1
-
Official Full Name
pim-1 oncogene
-
Overview
PIM-1 is a member of the serine/threonine kinase PIM oncogene family. PIM-1 has been implicated in lymphomagenesis, cell proliferation, apoptosis, differentiation and tumourigenesis. The PIM-1 protein kinase is upregulated in prostate cancer. -
Synonyms
PIM1; pim-1 oncogene; PIM; serine/threonine-protein kinase pim-1; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1); proto-oncogene serine/threonine-protein kinase pim-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PIM1 Related Articles
- PIM1 Related Research Area
- PIM1 Related Signal Pathway
PIM1 involved in several pathways and played different roles in them. We selected most pathways PIM1 participated on our site, such as Jak-STAT signaling pathway, MicroRNAs in cancer, Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Jak-STAT signaling pathway | IL2RB;IL22RA2;IL4;RAF1A;SOCS6B;IFNE;PIAS4B;STAT1A;IFNA17 |
MicroRNAs in cancer | IGF2BP1;PDGFB;CCND2;DDIT4;RDX;ROCK1;TNXB;RECK;PDGFRA |
Acute myeloid leukemia | LEF1;PIK3R1;RPS6KB1;MAP2K2;NRAS;STAT3;SOS1;CCNA1;KIT |
PIM1 has several biochemical functions, for example, ATP binding, manganese ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIM1 itself. We selected most functions PIM1 had, and list some proteins which have the same functions with PIM1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | NDUFA13;FAM20B;ACTC1A;SEPHS1;KIF9;PPIP5K1;UBE2H;EPHB1;SCYL3 |
manganese ion binding | DCP2;PPM1M;GALNT2;PEPD;ENDOU;HMGCL;TDP2B;XPNPEP3;MPPE1 |
protein binding | VPS53;FLT4;MAT2B;NFS1;BACE1;WHSC1L1;NUP35;FAM81B;CARTPT |
protein serine/threonine kinase activity | PAK7;VPRBP;ALPK1;TSSK3;CAMK1GA;ADCK1;PRPF4B;TSSK1;MAP3K13 |
ribosomal small subunit binding | MTIF3;NME1;DHX29;DDX3X;ERAL1;PTCD3;NPM1;CPEB2;PIM1 |
transcription factor binding | EP300;NFATC4;HDAC7;PSMD10;GTF2B;PSMC5;HES7;NAB1;GCM1 |
PIM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIM1.
RPS19; TFPT; FH; FXR2; NHLH1; BEND7
- Q&As
- Reviews
Q&As (7)
Ask a questionPIM1 phosphorylates a variety of substrates, including BAD, c-Myc, and eIF4B. Phosphorylation of BAD inhibits its pro-apoptotic function, while phosphorylation of c-Myc and eIF4B enhances their transcriptional and translational activities, promoting cell survival and protein synthesis, respectively.
PIM1 activity is regulated by several signaling pathways, including the PI3K/AKT and JAK/STAT pathways. Activation of these pathways leads to the phosphorylation and activation of PIM1, while inhibition of these pathways can result in reduced PIM1 activity.
Further research is needed to assess the potential of PIM1 as a prognostic marker and therapeutic target in different cancer types. Understanding the specific roles of PIM1 in various cancers and its interactions with other signaling pathways will help determine its clinical relevance and potential utility in personalized cancer treatment strategies.
PIM1 has been implicated in promoting cell proliferation, survival, and resistance to apoptosis, contributing to cancer development. Its overexpression has been observed in various cancer types and is associated with poor prognosis. PIM1 also interacts with oncogenic signaling pathways, further promoting tumor growth and progression.
Several small molecule inhibitors targeting PIM1 kinase activity have been developed and show promise as potential therapeutics. These inhibitors can selectively inhibit PIM1 activity and have demonstrated anti-tumor effects in preclinical studies. Combination therapy with PIM1 inhibitors and other targeted drugs may also be a viable approach for treating PIM1-driven cancers.
PIM1 regulates cell cycle progression and proliferation by phosphorylating key substrates, such as p27 and CDC25A, which control the activity of cyclin-dependent kinases (CDKs). This phosphorylation promotes the degradation of p27 and stabilizes CDC25A, leading to enhanced CDK activity and cell cycle progression.
PIM1 expression can be regulated by various factors, including cytokines, growth factors, and oncogenic signals. These factors can activate specific transcription factors, such as STAT3 and NF-κB, which bind to the PIM1 promoter and enhance its transcriptional activity, resulting in increased PIM1 expression.
Customer Reviews (3)
Write a reviewWith the combination of this protein reagent's instructions, I can easily accomplish experimental design and operation.
With consistent and reliable results, this protein reagent is ideal for research projects that require replicability.
Following the use of this protein reagent, the reproducibility of my experiments has significantly improved, and I am highly satisfied.
Ask a Question for All PIM1 Products
Required fields are marked with *
My Review for All PIM1 Products
Required fields are marked with *