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Pla2g12b

  • Official Full Name

    phospholipase A2, group XIIB

  • Overview

    Mouse Group XIIB secretory phospholipase A2-like protein, also knownas Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and Pla2g12b, is a secreted protein which belongs to the phospholipase A2 family. Pla2g12b / PLA2G13 is strong expression in liver, small intestine and kidney. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids.
  • Synonyms

    GXIIB; FKSG71; PLA2G13; GXIIIsPLA2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLA2G12B-1880H Recombinant Human PLA2G12B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Pla2g12b-1192M Recombinant Mouse Pla2g12b protein, His-tagged HEK293 His Met1-Leu195
Mouse PLA2G12B-1866MCL Recombinant Mouse PLA2G12B cell lysate Human Cell N/A
Mouse Pla2g12b-4896M Recombinant Mouse Pla2g12b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish PLA2G12B-12601Z Recombinant Zebrafish PLA2G12B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Pla2g12b involved in several pathways and played different roles in them. We selected most pathways Pla2g12b participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pla2g12b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismPPAP2CB;DGKQ;CEPT1B;DGKD;PCYT1AB;PGS1;DGKZ;PLD1A;PLD4
Ether lipid metabolismPLA2G6;GAL3ST1A;PAFAH1B1A;PLA2G2A;PPAP2C;PPAP2D;ENPP2;CEPT1;PLA2G5
Arachidonic acid metabolismPLA2G2F;CYP2P10;PLA2G12A;FAAH2;GPX2;LTC4S;CBR1;PLA2G2E;PTGES2
Linoleic acid metabolismPLA2G4A;PLA2G12A;PLA2G3;PLB1;CYP2P7;CYP3A25;PLA2G6;CYP2P10;CYP2C37
alpha-Linolenic acid metabolismACAA1A;ACAA1;PLA2G4F;PLA2G4A;PLA2G4AA;PLA2G10;FADS2;PLA2G5;PLA2G2D
Metabolic pathwaysPOLR2K;DGAT2;Ckmm;GPI;NOS1;PYCR1A;ITPKB;UROC1;PLCD3
Ras signaling pathwaySOS1;VEGFC;PIK3CB;PLA2G2A;RALBP1;PIK3R1;CALML5;PLA2G4C;FGF17
Vascular smooth muscle contractionGNA11B;PLA2G4AA;PRKCD;CYP4A10;PLCB2;MYLK3;CALML3;ADCY1A;MYL9A
Pancreatic secretionPLA2G2E;PRSS3;CPA3;ITPR1;CPA2;CTRB1;PLA2G3;ATP2A2;ATP1A4
Fat digestion and absorptionAGPAT2;MOGAT3;SCARB1;PLA2G5;FABP1;APOB;DGAT2;Cel;GOT2

Pla2g12b has several biochemical functions, for example, calcium ion binding, metal ion binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by Pla2g12b itself. We selected most functions Pla2g12b had, and list some proteins which have the same functions with Pla2g12b. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPROZ;RCN1;MEGF6;GAS6;FREM1A;PSPH;PLCH1;CALM3A;CRTAC1
metal ion bindingCOL27A1A;HDAC5;ERI3;FUZ;GTPBP8;ZNF334;ZIK1;TNNI1;ZNF136
molecular_functionTMEM221;OXNAD1;NEMF;DONSON;PRRT3;D1ERTD622E;GM10230;RAI2;GM4307
phospholipase A2 activityPLA2G2E;RARRES3;PLA2G10;PLA2G4A;PLA2G1B;PLA2G2D;PLA2G2F;PLA2G16;PLA2G6

Pla2g12b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pla2g12b here. Most of them are supplied by our site. Hope this information will be useful for your research of Pla2g12b.

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