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PPARG

  • Official Full Name

    peroxisome proliferator-activated receptor gamma

  • Overview

    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Synonyms

    PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Flag
  • GST
  • His
  • HIS
  • His (Fc)
  • Avi
  • His|MBP
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPARG-67H Active Recombinant Human PPARG, His-tagged E.coli HIS
Human PPARG-2772H Recombinant Human PPARG, 209-477 aa, His-tagged E.coli His
Human PPARG-1872H Recombinant Human PPARG, GST-tagged E.coli GST 29-139aa
Human PPARG-28670TH Recombinant Human PPARG E.coli N/A
Human PPARG-1090H Recombinant Human PPARG, Ligand Binding Domain, His-tagged E.coli His
Human PPARG-1091H Recombinant Human PPARG, Ligand Binding Domain, GST-tagged E.coli GST
Human PPARG-7002H Recombinant Human PPARG protein, His&GST-tagged Insect Cells His/GST Met1-Tyr505
Human PPARG-321H Recombinant Human PPARG protein, His/MBP-tagged E.coli His/MBP 4-306 aa
Human PPARG-4935H Recombinant Human PPARG Protein, His-tagged E. coli His
Human PPARG-30104TH Recombinant Human PPARG, His-tagged E.coli His
Human PPARG-28671TH Recombinant Human PPARG E.coli N/A
Human PPARG-31034TH Recombinant Human PPARG, His-tagged E.coli His
Human PPARG-68H Recombinant Human PPARG, 1-477aa, His-tagged E.coli His
Human PPARG-492HCL Recombinant Human PPARG cell lysate Insect Cell N/A
Human PPARG-6217H Recombinant Human PPARG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPARG-1838HFL Recombinant Full Length Human PPARG Protein, C-Flag-tagged Mammalian cells Flag
Human PPARG-3360H Recombinant Human PPARG protein, His-SUMO-tagged E.coli His-SUMO 1-477aa
Human PPARG-0777H Recombinant Human PPARG Protein (P234-Y505), Tag Free E.coli No tag P234-Y505
Human PPARG-0778H Recombinant Human PPARG Protein (P234-Y505), His tagged E.coli His P234-Y505
Human PPARG-2602H Recombinant Human PPARG Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PPARG-1741H-B Recombinant Human PPARG Protein Pre-coupled Magnetic Beads HEK293
Human PPARG-5244H Recombinant Human PPARG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPARG-5941H Recombinant Human PPARG Protein (Asp230-Tyr505), N-His tagged E.coli N-His Asp230-Tyr505
Human PPARG-5498H Recombinant Human PPARG protein, His-tagged Yeast His 1-477aa
Human PPARG-1741H Recombinant Human PPARG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PPARG-13162M Recombinant Mouse PPARG Protein Mammalian Cell His
Mouse Pparg-39M Recombinant Mouse Pparg protein, His-tagged E.coli His Phe149~Ser273
Mouse PPARG-6969M-B Recombinant Mouse PPARG Protein Pre-coupled Magnetic Beads HEK293
Mouse Pparg-3362M Recombinant Mouse Pparg protein, His-tagged E.coli His 1-505aa
Mouse PPARG-6969M Recombinant Mouse PPARG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pparg-3361M Recombinant Mouse Pparg protein, His-SUMO-tagged E.coli His-SUMO 1-505aa
Mouse Pparg-5030M Recombinant Mouse Pparg Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pparg-1961M Recombinant Mouse Pparg Protein, His-tagged E.coli N-His Lys347-Glu488
Rat PPARG-4593R Recombinant Rat PPARG Protein Mammalian Cell His
Rat Pparg-7879R Recombinant Rat Pparg protein, His-tagged E.coli His Gln311~Leu493 (Accession # O88275)
Rat PPARG-4253R Recombinant Rat PPARG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPARG-4253R-B Recombinant Rat PPARG Protein Pre-coupled Magnetic Beads HEK293
Rabbit PPARG-7880R Recombinant Rabbit PPARG protein, His-tagged E.coli His Phe280~Tyr475 (Accession # O19052)
Cattle PPARG-7878C Recombinant Cattle PPARG protein, His-tagged E.coli His Gln311~Ile500 (Accession # O18971)
Cynomolgus Monkey PPARG-804C Recombinant Cynomolgus PPARG Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PPARG-547C Recombinant Cynomolgus Monkey PPARG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PPARG-547C-B Recombinant Cynomolgus Monkey PPARG Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PPARG-3537R Recombinant Rhesus monkey PPARG Protein, His-tagged Mammalian Cell His
Rhesus Macaque PPARG-3355R Recombinant Rhesus Macaque PPARG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PPARG-3355R-B Recombinant Rhesus Macaque PPARG Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PPARG-9032Z Recombinant Zebrafish PPARG Mammalian Cell His
Chicken PPARG-1103C Recombinant Chicken PPARG Mammalian Cell His
CBCRY34 Peroxisome Proliferator-activated Receptor Gamma E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPARG Related Articles
  • PPARG Related Research Area

PPARG involved in several pathways and played different roles in them. We selected most pathways PPARG participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayAPOA1A;ACAA1;CYP8B1;ILK;FABP3;PPARDB;DBI;RXRB;SLC27A1A
AMPK signaling pathwayTBC1D1;CAMKK1;FBP1;SIRT1;PFKP;CCNA1;ADIPOQ;IRS4;PPP2CA
Osteoclast differentiationIFNGR2;IFNGR1;LILRB1;IL1R1;PIK3CB;MAPK1;PLCG2;SOCS3;RAC1
Huntingtons diseaseITPR1;CREB3L2;NDUFB8;ATP5G1;HDAC1;NDUFS7;NDUFB5;DNAH11;BDNF
Pathways in cancerNFKB2;BMP4;GNG11;PTGER4;GLI2;HSP90AA1;SOS1;PDGFRB;WNT9B
Transcriptional misregulation in cancerPTK2;TRP53;HOXA9;ITGB7;IGF1R;PRCC;HOXA10;SFPI1;PPARG
Thyroid cancerRET;NTRK1;LEF1;RXRG;BRAF;KRAS;MAPK3;MAP2K1;MAPK1

PPARG has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARG itself. We selected most functions PPARG had, and list some proteins which have the same functions with PPARG. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF582;PURBB;POLRMT;ARHGEF38;DDIT3;ELF2A;MESP1;STAT1B;EXO1
RNA polymerase II regulatory region DNA bindingATXN3L;NKX2-1;TXK;PPARG;NPAS4;NCOA1
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingRORA;NR2F6A;ESR2;RXRB;RORC;NR2F6;NR1I3;NR2F1A;PPARAB
WW domain bindingTCEAL2;NFE2;TCEAL3;KIF20B;PMEPA1;TRP63;TCEAL6;WBP5;DNM2
activating transcription factor bindingPPARG;TAF9;DGKQ;ZFP516;MEF2C;MEF2A;EP300;PRDM16;MEF2D
alpha-actinin bindingKCNA5;PPARG;XIRP2;ALMS1;ADORA2A;MYOT;LRRC10;MAGI1;KCNN2
arachidonic acid bindingS100A9;PPARG;CYP4F14;CYP4A14;ALOX5AP;STX3;S100A8
chromatin bindingSIN3A;PHF8;SOX14;NCOA2;ZEB1;ASF1A;HDGFRP2;BRD4;GATA3
core promoter sequence-specific DNA bindingCRY1;RORA;GATA3;THRAP3;NRF1;SOHLH1;NRIP1;NR4A3;TRP53
drug bindingIL2RA;CHRNA2;TYMS;DRD4;DRD1A;HMGB2;ADRB2;SMO;ABP1
enzyme bindingC2orf56;MDM2;PTPN1;PHKG1;ABCD1;ZFP36;RPA2;MSH3;HAND2
estrogen receptor bindingSTRN;LEF1;XBP1;PHB2;MMS19;FUS;PADI2;TAF10;HSD17B10
ligand-dependent nuclear receptor transcription coactivator activitySMARCD3;NCOA1;DCAF6;PPARGC1B;PRKCB;ZCCHC18;THRAP3;SRA1;ENY2
metal ion bindingOLA1;ZNF485;RPS6KAL;PDE6B;MGAT1;KMT2A;JADE3;MAP2K2;CIT
protein bindingEYA2;TNF;LYRM2;ADRB3;ZNF295;PALLD;ZC3HAV1;MEI4;TRAM2
protein phosphatase bindingSNX3;HSF4;EIF2AK3;JAK1;JUP;VCAN;EGFR;GNB2L1;TRAF2
retinoid X receptor bindingNR1H4;HMGA1;HMGA1-RS1;FUS;NR4A2;NRIP1;RARG;RARB;MED25
contributes_to sequence-specific DNA bindingNEUROD1;HIF1A;ARNT;SMAD4;TRIM28;FIGLA;HNRNPAB;HDAC4;PPARG
steroid hormone receptor activityRXRG;NR2F1A;RXRB;PPARDB;NR2F1B;PPARAB;NR2F6B;RARA;RXRBB
transcription factor activity, sequence-specific DNA bindingSLC12A9;OTX1A;PPARG;ZHX2;SOX13;ZNF397;ARID4A;POU2F1B;POU3F2A
transcription factor bindingIFI203;HDAC7;NFATC2;NR0B2;ZFPM2;PELP1;MECP2;SOX8;RBFOX2
transcription regulatory region DNA bindingZNF335;TFE3;PRDM5;CBX4;SMAD6;HINFP;WNT1;KDM1A;GLIS2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingHIF1A;STAG2;AIRE;HOXD8;PPARG;SOX17;GLIS1;OVOL2;ZGLP1
zinc ion bindingTRPS1;SEC23A;GFI1AA;PIAS3;TRIM14;L3MBTL4;CPB2;TXNDC17;ALKBH8

PPARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARG here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARG.

Sirt1; MED1; SIRT1; Prdm16; ucp1_mouse_gene

Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
Oysyannikova, IG; White, SJ; et al. Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. VACCINE 32:881-887(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How many isoforms of PPARG are there, and what are their weights? 04/07/2022

PPARG has two isoforms, PPARG1 (57 kDa) and PPARG2, a splice variant with an additional 30 amino acids at the N-terminus.

What is the molecular weight of PPARG? 12/16/2021

PPARG has two isoforms with molecular weights of 57 kDa and 54 kDa. Modified PPARG is about 67 kDa.

What does PPARG stand for? 02/02/2021

PPARG stands for Peroxisome Proliferator-Activated Receptor Gamma.

Is there a mitochondria-localized form of PPARG? 01/21/2021

Yes, experimental data suggests a 45 kDa protein immunologically related to PPARG, called mt-PPAR, is located in mitochondria. Its molecular weight is less than PPARG2.

What is the role of PPARG in cellular function? 12/20/2019

PPARG is a ligand-activated transcription factor that plays a crucial role in regulating lipid homeostasis, adipogenesis, insulin resistance, and organ development.

What are the known diseases associated with PPARG defects? 11/10/2017

Defects in PPARG are associated with familial partial lipodystrophy type 3 (FPLD3), susceptibility to obesity, type 2 insulin-resistant diabetes, hypertension, and colon cancer.

Where is PPARG mainly localized? 03/19/2017

PPARG is mainly localized in the nucleus, although it can also be detected in the cytoplasm, exhibiting extra-nuclear/non-genomic actions in certain contexts.

Customer Reviews (3)

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Reviews
09/15/2020

    It was reassuring to use a product that adhered to green chemistry principles, reducing our impact on the environment.

    06/03/2017

      The company's dedication to environmental sustainability reflected positively on the product and our research initiatives.

      05/04/2017

        We appreciated the option to request modifications or custom formulations to meet our project's requirements.

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