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Prkca

  • Official Full Name

    protein kinase C, alpha

  • Overview

    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Synonyms

    PRKCA; protein kinase C, alpha; AAG6; PKCA; PRKACA; PKC-alpha; protein kinase C alpha type; PKC-A; aging-associated gene 6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKCA-153HFL Active Recombinant Full Length Human PRKCA Protein, N-His-tagged Sf21 His Full Length
Human PRKCA-347H Recombinant Human PRKCA Mammalian Cell His
Human PRKCA-1087H Recombinant Human Protein Kinase C, Alpha, GST-tagged Sf9 Insect Cell GST
Human PRKCA-648H Recombinant Human Protein Kinase C, Alpha Insect Cell N/A
Human PRKCA-398H Recombinant Human Protein Kinase C, Alpha, GST-tagged, Active Sf9 Insect Cell GST
Human PRKCA-1301H Recombinant Human Protein Kinase C, Alpha, His-tagged E.coli His
Human PRKCA-58H Recombinant Human protein kinase C, Alpha, His-tagged Sf9 Insect Cell His
Human PRKCA-499HCL Recombinant Human PRKCA lysate HEK293 N/A
Human PRKCA-3962HF Active Recombinant Full Length Human PRKCA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-672(end)
Human PRKCA-3385HF Active Recombinant Full Length Human PRKCA Protein, GST-tagged Insect (sf21) GST 1-672(end)
Human PRKCA-011H Recombinant Human PRKCA Protein, GST-tagged Insect cell GST 1-672
Human PRKCA-3909H Recombinant Human PRKCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRKCA-0187H Recombinant Human PRKCA Protein (A2-V672), Tag Free Insect Cell No tag A2-V672
Human PRKCA-0188H Recombinant Human PRKCA Protein (A2-V672), GST tagged Insect Cell GST A2-V672
Human PRKCA-3909H-B Recombinant Human PRKCA Protein Pre-coupled Magnetic Beads HEK293
Mouse PRKCA-13361M Recombinant Mouse PRKCA Protein Mammalian Cell His
Mouse Prkca-1971M Recombinant Mouse Prkca protein, His & S-tagged E.coli His/S Phe339~Phe597 (Accession # P20444)
Mouse PRKCA-7092M Recombinant Mouse PRKCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRKCA-7092M-B Recombinant Mouse PRKCA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PRKCA-3604R Recombinant Rhesus monkey PRKCA Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRKCA-3422R Recombinant Rhesus Macaque PRKCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRKCA-3422R-B Recombinant Rhesus Macaque PRKCA Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRKCA-8136Z Recombinant Zebrafish PRKCA Mammalian Cell His
Chicken PRKCA-2032C Recombinant Chicken PRKCA Mammalian Cell His
Prkca-397X Recombinant Xenopus Prkca, GST-tagged, Active Sf9 Insect Cell GST
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Prkca Related Research Area

Prkca involved in several pathways and played different roles in them. We selected most pathways Prkca participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prkca were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayHSPA8;CACNB4;Fgf15;PLA2G4A;MYCB;FGF19;HRAS;CACNA2D1A;MAPK8
ErbB signaling pathwayCAMK2G;MAPK10;MAP2K2A;PAK6;ERBB4;PIK3CD;AKT1;PTK2AA;MAP2K1
Ras signaling pathwayPRKACG;TBK1;RELA;ANGPT2;MAPK1;RALBP1;SHOC2;Pdgfa&Pdgfb;RGL2
Rap signaling pathwayPLCE1;RRAS;TEK;CDH1;RAPGEF5;PIK3CB;PRKCG;PRKD1;PLCB2
Calcium signaling pathwayGNA11B;SLC8A3;Adcy4;DRD1B;VDAC1;PPIFA;RYR2;GNA15.4;PHKG2
HIF- signaling pathwayRPS6;IFNGR2;NOS2;TEK;VHL;IL6R;AKT2;HIF1A;PIK3R2
Phosphatidylinositol signaling systemPRKCB;CALM2B;CALM1;DGKE;PRKCA;PI4KAA;PIK3R3B;PIP5K1AB;INPP5J
Sphingolipid signaling pathwayROCK2;TNFRSF1A;SPTLC3;TRADD;PPP2R5A;ACER1;S1PR5;MAPK3;PIK3R2
Phospholipase D signaling pathwayINS;AKT2;GRM4;Pdgfa&Pdgfb;AVPR2;KRAS;PLD1;IL-8;ARF6
mTOR signaling pathwayPRKAA1;RPS6KB1;RRN3;INS1;RPS6KA1;AKT1;ULK3;VEGFA;RRAGD
PIK-Akt signaling pathwayPPP2R2C;FGF9;GNG3;ITGA2;LAMA1;IFNAR1;PPP2R1A;RPS6KB2;FGF22
Adrenergic signaling in cardiomyocytesPPP2CB;CACNG6A;PPP1CBL;ATP1A1B;CALM1B;AGTR1A;MYH15;CREB3L2;ADRB2A
Vascular smooth muscle contractionROCK2A;ITPR1;RAF1B;PRKACB;KCNMB1;KCNMA1A;MYL9A;PPP1CAA;RHOAD
Wnt signaling pathwayFZD7B;CACYBP;RBX1;WNT16;Fzd4;NFATC4;CAMK2D;VANGL2;RHOAD
VEGF signaling pathwayPTK2AB;MAPKAPK2A;PTGS2;PIK3R2;PRKCG;RAC3A;VEGFA;MAP2K2A;PIK3R1
Focal adhesionIGF1RA;CAV2;AASS;PPP1CB;ITGA3;IGF1;BRAF;DIAPH1;CAPN2B
Tight junctionEPB41L1;MAGI1;INADL;LLGL1;F11R;CLDNF;PPP2R1A;MLLT4;CLDN19
Gap junctionGNAQ;PRKG1A;PRKACBB;PRKCB;TUBAL3;PDGFA;DRD2B;GNAI2B;ADCY1B
Natural killer cell mediated cytotoxicityHLA-A;IFNA14;KLRC4-KLRK1;ITGB2L;KLRK1;TNFRSF10D;CD247;GZMB;ULBP1
Fc epsilon RI signaling pathwayRAC2;GRB2;PLA2G4D;PLA2G4A;MAP2K2;MAP2K1;PIK3R5;PIK3R2;MAP2K7
Fc gamma R-mediated phagocytosisRAC2;PRKCG;FCGR1A;PPAP2C;RPS6KB2;PTPRC;SPHK1;PRKCD;PAK1
Leukocyte transendothelial migrationNOX1;RAC2;ITGAL;MYL9;MYL10;CLDN14;PTK2B;ARHGAP5;PRKCB
Circadian entrainmentITPR3;CAMK2D;GNAS;MTNR1A;FOS;GNAI2;CALM4;ADCYAP1R1;GRIA4
Long-term potentiationGRIN2B;RAP1A;PPP1R1A;CALM4;GRIN2C;CALM1;GRM5;ATF4;GRIA2
Retrograde endocannabinoid signalingSLC17A8;GNG12;GABRP;PLCB2;GNB1;GRM5;GNG13;GNAQ;GNB2
Glutamatergic synapseGRIA1;PPP3CA;PPP3R2;TRPC1;ADRBK2;SLC17A6;GRIK4;ITPR1;PLA2G4F
Cholinergic synapseKCNJ6;CHRNA6;PRKACB;PRKCB;KCNQ2;PIK3R5;GNAQ;KCNJ4;GNG12
Serotonergic synapseNRAS;GABRB2;ARAF;CYP2C39;BRAF;SLC18A2;PLCB1;HTR2C;GNAS
GABAergic synapseGNAO1;GNB3;GABRA2;Adcy4;GABRA4;GNAI3;GABRR2;GNG11;PRKACG
Dopaminergic synapsePPP2R5B;GSK3A;PPP2R3A;MAPK10;GNG10;MAOB;GRIA2;GNG7;CREB3L2
Long-term depressionPRKCA;ITPR1;GNAI1;ARAF;GNAZ;MAPK3;PPP1R17;PLCB2;NOS1
Inflammatory mediator regulation of TRP channelsCALML5;PPP1CC;PLA2G4F;ITPR3;CYP2C54;Adcy4;ACCN4;CAMK2G;NTRK1
Insulin secretionATP1A1;KCNN1;PRKACG;ATP1B4;SNAP25;KCNMB2;ATP1B2;TRPM4;INS
GnRH signaling pathwayCAMK2D1;CGNRH-R;LHBETA1;MAP2K6;GNRHR2;ITPR1;CACNA1C;CALM1;CDC42L2
MelanogenesisPRKACA;GSK3AA;POMC;NRAS;KITLG;PRKACB;MITFA;WNT3A;WNT2B
Thyroid hormone synthesisDUOXA2;ATP1A3;ATP1A4;PLCB3;GNAQ;ATP1A2;TSHR;GNAS;TTF2
Thyroid hormone signaling pathwayACTG1;FXYD2;SLC9A1;PIK3R2;GATA4;PIK3R1;ESR1;PDPK1;MED30
Oxytocin signaling pathwayPIK3R2;PPP1R12C;PLCB4;PPP1R12A;PLA2G4F;CALM2;NFATC4;RAF1;PIK3CG
Aldosterone synthesis and secretionCREB3L3;LDLR;CALM4;PRKCE;CREB5;NETO2;CREB3;CALML5;HSD3B1
Aldosterone-regulated sodium reabsorptionPIK3R1;PIK3R3;IRS1;ATP1A4;INS;PIK3R5;NEDD4L;ATP1B4;ATP1A2
Endocrine and other factor-regulated calcium reabsorptionCALB1;KLK1B3;VDR;KLK1B5;KLK1B1;ATP1A1;PRKACG;ATP2B1;KLK1B11
Salivary secretionTRPV6;GUCY1B3;CST4;GNAQ;LYZ;HTN1;KCNN4;ATP1B4;PLCB1
Gastric acid secretionMYLK2;CALML3;MYLK3;KCNJ15;KCNK10;SLC9A4;ITPR3;KCNJ1;Adcy4
Pancreatic secretionPLA2G2A;PRKCG;CCKAR;PLA2G3;PNLIP;TPCN2;ITPR1;AMY2B;ATP1B1
Vibrio cholerae infectionATP6V1E2;ERO1L;GNAS;ATP6V0B;ATP6V1B1;ATP6V1C1;PRKACB;MUC2;ATP6V0D1
Pathogenic Escherichia coli infectionTUBA3C;TUBA1C;TUBA1A;CDH1;WAS;TLR4;ACTB;PRKCA;TUBA1B
African trypanosomiasisPLCB1;HBA-A2;THOP1;HBB;TLR9;MYD88;PRKCB;PRKCA;SELE
AmoebiasisGNA15;C9;CTSG;PIK3R5;AASS;PIK3CB;ITGAM;PRKCB;ACTN1
Hepatitis BSTAT5A;IKBKB;IFNA1;CCNE1;TGFBR1;CASP12;AKT1;PCNA;STAT1
Influenza AIFNB1;IFNA12;CXCL8;CXCL10;PIK3CA;MAP2K1;STAT1;DDX58;RAE1
Pathways in cancerGNAI1;TCF7L2;ROCK2;BAD;LAMA2;TFG;STAT3;WNT2B;GNAI2
Proteoglycans in cancerFZD1;VTN;VAV2;CBL;PPP1CB;ESR1;PRKACA;PTPN11;VEGFA
MicroRNAs in cancerHOXD10;RPTOR;MMP9;MARCKS;DNMT3A;NOTCH1;DNMT1;MCL1;NOTCH2
GliomaAKT2;Pdgfa&Pdgfb;TRP53;PLCG1;SHC1;PDGFB;CAMK2B;CALM2;PTEN
Non-small cell lung cancerCASP9;RASSF5;ARAF;BAD;MAP2K1;MAP2K2;PLCG1;ERBB2;RARB
Choline metabolism in cancerPLA2G4A;PIK3R3;SLC22A5;DGKE;PPAP2A;PPAP2B;FOS;PCYT1A;GRB2

Prkca has several biochemical functions, for example, ATP binding, calcium-dependent protein kinase C activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prkca itself. We selected most functions Prkca had, and list some proteins which have the same functions with Prkca. You can find most of the proteins on our site.

Function Related Protein
ATP bindingAatk;HSPA12A;CLCN4-2;ACSL5;PRKG1;ACVR2AA;CHUK;BMPR1A;CCT2
calcium-dependent protein kinase C activityCCL3;PRKCG;ALPK2;PRKCA
enzyme bindingAPBA3;MST1R;PYCARD;HIST1H2AG;ARRB2;PARP4;UBE4B;HIST1H2AK;GOT2
histone kinase activity (H3-T6 specific)PRKCA;PRKCBB;PRKCB
protein bindingHNF1A;SHANK3;GAD2;RBM22;TCEA2;RND2;CEP76;SNX4;LGR6
protein kinase C activityPRKCA;PKN2;PRKCHA;PRKCHB;PKN1;PRKD1;PRKCG;PRKCD;PRKCI
protein kinase activityGRK7B;PRKCA;PTK7A;DCLK3;CDKL2;SMOK2B;MKNK2A;ABL2;STK30
protein serine/threonine kinase activityRPS6KB1B;STK35;NUAK2;MAP3K2;ERN1;PIM1;MAPK12A;MARK4;CIT
zinc ion bindingYY1;RORCB;DRL;MAN2B1;MMP12;TAF2;MMP14;PRKCBB;SETMAR

Prkca has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prkca here. Most of them are supplied by our site. Hope this information will be useful for your research of Prkca.

EGFR; Sdc4; bzlf1_ebvb9; NCF1; numb; SDC4; ndb25_parsc; inaD; Jak2; GIPC1; EIF2S1; HSP90AB1; UBC; BRAF

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Customer Reviews (3)

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Reviews
03/12/2020

    When utilized in Western Blotting experiments, the PRKCA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

    10/16/2017

      I have successfully implemented the PRKCA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

      01/09/2016

        Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the PRKCA protein in various research studies.

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