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Protein L

Overview

Protein L was first isolated from the surface of bacterial species Peptostreptococcus magnus and was found to bind immunoglobulins through L chain interaction, from which the name was suggested. It consists of 719 amino acid residues. The molecular weight of Protein L purified from the cell walls of Peptostreptoccus magnus was first estimated as 95kD by SDS-PAGE in the presence of reducing agent 2-mercaptoethanol, while the molecular weight was determined to 76kD by gel chromotography in the presence of 6 M guanidine HCl. Protein L does not contain any interchain disulfide loops, nor does it consist of disulfide-linked subunits. It was an acidic molecular with a PI of 4.0. Unlike Protein A and Protein G, which bind to the Fc region of immunoglobilins (antibodies), Protein L binds antibodies through light chain interactions. Since no part of the heavy chain is involved in the binding interaction, Protein L binds a wider range of antibody classes than Protein A or G. Protein L binds to representatives of all antibody classes, including IgG, IgM, IgA, IgE and IgD. Single chain variable fragments (scFv) and Fab fragments also bind to Protein L.
Synonyms

Protein L; PpL; Protein L Type 1 Protein; RPL; rProtein L;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Peptostreptoccocus magnus	Protein L-528	Recombinant Staphylococcal L Protein, biotin-labeled		N/A	Inquiry
Peptostreptococcus magnus	Protein L-3141P	Active Recombinant Peptostreptococcus magnus Protein L protein, His-tagged	E.coli	His	Inquiry
Peptostreptococcus magnus	Protein L-8141P	Active Recombinant Peptostreptococcus magnus Protein L protein, Biotin/His-tagged	E.coli	Biotin/His	Inquiry
	Protein L-546M	Active Protein L-coupled magnetic Beads			Inquiry

Protein L Related Articles

Protein L involved in several pathways and played different roles in them. We selected most pathways Protein L participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Protein L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

Protein L has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Protein L itself. We selected most functions Protein L had, and list some proteins which have the same functions with Protein L. You can find most of the proteins on our site.

Function	Related Protein

Protein L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Protein L here. Most of them are supplied by our site. Hope this information will be useful for your research of Protein L.

Lin, JH; Wang, RH; et al. An impedance immunosensor based on low-cost microelectrodes and specific monoclonal antibodies for rapid detection of avian influenza virus H5N1 in chicken swabs. BIOSENSORS & BIOELECTRONICS 67:546-552(2015).

Mori, N; Ishikawa, C; et al. Activation of PKC-delta in HTLV-1-infected T cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1609-1618(2015).