Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ANG

  • Official Full Name

    Angiogenin

  • Overview

    Angiogenin (Ang) also known as ribonuclease 5 is a protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Hooper et al. (2003) reviewed the evidence that angiogenins are involved in host defense and noted that inflammation provokes upregulated ANG mRNA expression in liver and an increase in detectable ANG protein in serum. Weremowicz et al. (1989, 1990) assigned the human angiogenin gene to chromosome 14q11.
  • Synonyms

    Angiogenin; Ang; ribonuclease 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANG-548H Recombinant Human ANG protein, GST-tagged Wheat Germ GST
Human ANG-5108H Recombinant Human ANG, His-tagged E.coli His
Human ANG-9641H Active Recombinant Human ANG protein, His-tagged E.coli His Gln 25 - Pro 147
Human ANG-507H Recombinant Human angiogenin, ribonuclease, RNase A family, 5, His-tagged E.coli His
Human ANG-2629H Recombinant Human Angiogenin, Ribonuclease, RNase A Family, 5 E.coli N/A
Human ANG-20HCL Recombinant Human ANG lysate HEK293 N/A
Human ANG-27314TH Recombinant Human ANG Wheat Germ N/A 123 amino acids
Human ANG-0504H Recombinant Human ANG Protein (Gln25-Pro147), Tag Free E.coli Tag Free Gln25-Pro147
Human ANG-1424H Recombinant Human ANG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANG-2082H Recombinant Human ANG Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ANG-148H Recombinant Human ANG Protein, His-tagged E.coli N-His Asn79-Pro466
Human ANG-19HF Recombinant Full Length Human ANG Protein In Vitro Cell Free System 123 amino acids
Human ANG-1033HF Recombinant Full Length Human ANG Protein, GST-tagged In Vitro Cell Free System GST 147 amino acids
Human ANG-0503H Recombinant Human ANG Protein (Gln25-Pro147), N-His-tagged E.coli N-His Gln25-Pro147
Mouse ANG-1627M Recombinant Mouse ANG Protein Mammalian Cell His
Mouse Ang-3453M Recombinant Mouse Ang, His-tagged E.Coli or Yeast His 145
Mouse Ang-519M Recombinant Mouse Ang protein, His-tagged E.coli His Gln25 ~Leu145
Mouse Ang-520M Recombinant Mouse Ang protein, His & GST-tagged E.coli His/GST Gln25~Leu145 (Accession # P21570)
Mouse Ang-602M Recombinant Mouse Ang Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Ang-149M Recombinant Mouse Ang Protein, His-tagged E.coli N-His Val98-Trp436
Mouse ANG-524M Recombinant Mouse ANG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ANG-524M-B Recombinant Mouse ANG Protein Pre-coupled Magnetic Beads HEK293
Rat Ang-522R Recombinant Rat Ang protein, His & T7-tagged E.coli His/T7 Gln25~Phe142 (Accession # Q5WRG2)
Cattle ANG-518C Recombinant Cattle ANG protein, His-tagged E.coli His Ala24~His148
Pig ANG-521P Recombinant Pig ANG protein, His-tagged E.coli His Lys1~Gln123 (Accession # P31346)
Chicken ANG-6811C Recombinant Chicken ANG Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANG Related Articles
  • ANG Related Research Area

ANG involved in several pathways and played different roles in them. We selected most pathways ANG participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctions interactionsCDH18;CDH2;JUPA;CDH18A;CDH17;CTNNA1;CDH8;CDH12A;CDH3
Cell junction organizationCADM2B;TESK1;CADM2A;CTNND1;CLDN4;CLDN7;F11R.2;CDH18A;CDH10
Cell-Cell communicationKIRREL3L;CLDN3;DSCAMA;DST;ANG;KIRRELB;COL17A1;CDH13;CDH10A
Cell-cell junction organizationCLDN20;CDH8;JUPA;CLDN4;CDH17;JUP;CLDN23;CDH3;F11R.2

ANG has several biochemical functions, for example, DNA binding, actin binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANG itself. We selected most functions ANG had, and list some proteins which have the same functions with ANG. You can find most of the proteins on our site.

Function Related Protein
DNA bindingEGR4;POU3F1;HOXB4A;RAD51L1;DMTF1;POLR1E;CIC;RNF4;DRL
actin bindingLSP1;CAP2;BCL7B;TNS4;SNTB1;PPP1R9B;CLMN;CORO7;SMTNL
copper ion bindingCOMMD1;LOX;RNF7;ABHD1;SCO1;AOC1;LOXL3;AOC3;COX11
endonuclease activityPELO;ZRANB3;ANG4;SMG6;MRE11A;RAG1;RNASEL2;ANG3;DCLRE1C
heparin bindingZNF146;ADAMTSL5;APOH;THBS3;COL5A1;PLA2G2D;LXN;SELP;FGF1
peptide bindingTPP1;BDKRB1;CRHBP;CRIP1;PPYR1;ERAP1;GNRHR4;IDE;GPR37
protein bindingVANGL1;MID1IP1;MAD2L2;IST1;HSD17B14;KIAA0649;APBA3;TRAF5;DCTN1
protein homodimerization activityMCL1;Anks6;SYNDIG1;PTPRO;PRMT2;GRIK1;DNTTIP1;BMP4;HSP90AA1
rRNA bindingANG;RNASEL;EMG1;RPL8;RPS5;DDX21;TLR13;RPS11;RPS9
receptor bindingPKD2;UCN2;FKBP1B;NRG4;AGRP2;PTK2B;PICK1;CHRNA10;NPY
ribonuclease activityRNASE2;EAR1;ANG;RNASEL2;RNASEH2A;EAR2;RNASET2B;EAR5;RNASE7

ANG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANG here. Most of them are supplied by our site. Hope this information will be useful for your research of ANG.

ACTN2; FST; RNH1; TDGF1; FST; PTEN; ATP6AP1; ABCG8

Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
Can ANG protein be used as a therapeutic target? 06/06/2022

Given its involvement in angiogenesis and disease processes, ANG protein has been explored as a therapeutic target. However, more research is needed to fully understand its complex biology and potential for targeted therapies.

Can ANG protein be used as a prognostic indicator for cancer? 01/30/2021

ANG protein levels have been measured in various cancer types and have shown prognostic value in some cases. High levels of ANG protein have been associated with poor prognosis in certain cancers, indicating its potential as a prognostic biomarker.

What are the functions of ANG protein in neurodegenerative disorders? 10/09/2020

In neurodegenerative disorders, ANG protein is thought to have multiple functions. It has been shown to promote the survival of neurons and protect them from various kinds of stress. ANG protein also possesses ribonucleolytic activity, where it can cleave RNA molecules, and this activity may be important for its neuroprotective effects.

Is ANG protein involved in other cellular processes besides angiogenesis? 07/02/2020

Yes, ANG protein has been implicated in various cellular processes beyond angiogenesis. It has been found to play a role in cell survival, proliferation, migration, and RNA metabolism. ANG protein can also promote the growth of neurons and participate in synaptic plasticity.

Are there any known ANG protein mutations associated with diseases? 05/25/2020

Yes, several mutations in the ANG gene have been identified in individuals with neurodegenerative disorders such as ALS. These mutations can impair ANG protein function, leading to the development of the disease.

Can ANG protein levels be measured in clinical settings to assess disease progression or treatment response? 04/02/2020

ANG protein levels can be measured in clinical settings through various laboratory techniques, including enzyme-linked immunosorbent assays (ELISAs) or immunohistochemistry. However, the clinical utility of measuring ANG protein levels for assessing disease progression or treatment response remains to be fully established and is currently limited to specific research settings. Further studies are needed to determine its potential as a diagnostic or prognostic biomarker.

Is there a relationship between ANG protein and inflammation? 07/30/2019

Yes, there is evidence to suggest a relationship between ANG protein and inflammation. Inflammatory signals can induce the expression of ANG protein, and elevated ANG protein levels have been detected in inflamed tissues. ANG protein has also been shown to interact with components of the immune system and modulate immune responses in certain contexts.

Where is ANG protein found? 06/13/2019

ANG protein is found both intracellularly and extracellularly. It is present in various tissues, including endothelial cells, neurons, and certain cancer cells.

Are there any drugs or therapies targeting ANG protein in clinical trials? 04/09/2019

There are currently no FDA-approved drugs specifically targeting ANG protein. However, some preclinical studies have explored the use of ANG inhibitors or activators in different disease models, including cancer. Clinical trials investigating the therapeutic potential of ANG protein-targeted therapies are limited but may emerge in the future.

Does ANG protein have any role in cardiovascular health? 02/26/2019

ANG protein has been implicated in cardiovascular health and disease. It is involved in processes such as endothelial cell migration and vascular development. ANG protein has also been associated with conditions like atherosclerosis and ischemic heart disease, although further research is needed to fully understand its role in cardiovascular health and its potential as a therapeutic target.

Can ANG protein be used as a potential therapeutic target for neurodegenerative diseases? 02/18/2019

ANG protein has been investigated as a potential therapeutic target for neurodegenerative diseases, including ALS. However, developing effective therapies targeting ANG protein is challenging due to its involvement in various cellular processes and the need to specifically modulate its functions without causing detrimental side effects. Further research is needed to better understand the role of ANG protein in disease pathogenesis and identify potential therapeutic strategies.

What are the medical implications of ANG protein? 01/03/2019

ANG protein has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. In cancer, ANG protein can promote tumor growth and metastasis by inducing angiogenesis. In neurodegenerative disorders, ANG protein dysfunction has been linked to diseases like ALS (amyotrophic lateral sclerosis).

Is ANG protein used in any diagnostic tests? 10/26/2018

ANG protein levels have been measured in various disease states and can serve as a biomarker for certain conditions. For example, elevated ANG protein levels have been associated with certain cancers, making it potentially useful in diagnostic testing or monitoring disease progression.

Are there any known natural regulators or inhibitors of ANG protein activity? 06/11/2018

Yes, there are natural regulators and inhibitors of ANG protein activity. One example is the ribonuclease inhibitor protein, which can bind to ANG protein and inhibit its ribonucleolytic activity. Additionally, certain microRNAs have been found to regulate ANG protein expression levels.

Are there any inhibitors or activators of ANG protein? 05/19/2017

Yes, several small molecules and antibodies have been developed as inhibitors or activators of ANG protein. These molecules can be used for research purposes or potentially as therapeutic agents in treating diseases involving ANG protein dysregulation.

Does ANG protein play a role in the development of other neurological disorders besides ALS? 12/08/2016

While ANG protein has been primarily studied in relation to ALS, there is evidence to suggest its potential involvement in other neurological disorders. For example, altered ANG protein levels and genetic variations in the ANG gene have been associated with conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. However, more research is needed to fully elucidate the role of ANG protein in these disorders.

How is ANG protein related to amyotrophic lateral sclerosis (ALS)? 06/18/2016

ANG protein has been linked to ALS, a neurodegenerative disorder, through genetic mutations. Certain mutations in the ANG gene can lead to a decrease in ANG protein production or impair its function. This can contribute to the development of ALS, as ANG protein is involved in various processes that are important for maintaining the health and function of motor neurons.

Can ANG protein be targeted for anti-angiogenic therapies? 06/12/2016

ANG protein has been considered as a potential target for anti-angiogenic therapies. Inhibiting ANG protein's angiogenic activity could help in limiting pathological angiogenesis in diseases such as cancer. However, developing effective ANG inhibitors that specifically target pathological angiogenesis while sparing physiological angiogenesis remains a challenge.

Are there any animal models used to study ANG protein and its role in diseases? 02/28/2016

Yes, various animal models have been used to study ANG protein and its role in diseases. For example, mice models with genetically modified ANG genes have been created to mimic certain mutations associated with neurodegenerative disorders like ALS. These models allow researchers to investigate the impact of ANG protein dysfunction on disease development and progression.

How is ANG protein regulated? 02/21/2016

The expression and activity of ANG protein are regulated by various factors such as growth factors, cytokines, and cellular stress. Specific signaling pathways involving proteins like VEGF, HIF-1α, and PI3K/AKT are known to influence ANG protein regulation.

Customer Reviews (5)

Write a review
Reviews
09/27/2022

    Whether it's troubleshooting experimental hurdles or optimizing protocols, their dedicated team is there to guide me, ensuring smooth progress and successful outcomes.

    05/12/2022

      I am confident that their expertise and prompt assistance can help resolve any challenges I may encounter along the way.

      11/12/2020

        With their commitment to delivering high-quality products, I am confident in achieving successful outcomes and advancing my research.

        01/16/2019

          the exemplary technical support provided by the manufacturer adds immense value to my experience.

          04/01/2017

            If needed, the availability of bulk purchase options further optimizes resource allocation, enabling me to conduct extensive experiments without compromising on quality.

            Ask a Question for All ANG Products

            Required fields are marked with *

            My Review for All ANG Products

            Required fields are marked with *

            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends