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SAFB

Official Full Name

scaffold attachment factor B
Overview

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a transcriptosome complex in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

SAFB; scaffold attachment factor B; scaffold attachment factor B1; HET; Hsp27 ERE TATA binding protein; SAFB1; SAF-B; SAB-B1; HSP27 ERE-TATA-binding protein; Hsp27 ERE-TATA binding protein; glutathione S-transferase fusion protein; HSP27 estrogen response;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SAFB-2500H	Recombinant Human SAFB, GST-tagged	E.coli	GST	58-213aa	$319 / 25ug
Human	SAFB-29263TH	Recombinant Human SAFB	Wheat Germ	N/A	90 amino acids	Inquiry
Human	SAFB-2597H	Recombinant Human SAFB protein, His-tagged	E.coli	His	58-213 aa	$319 / 25ug
Mouse	SAFB-14642M	Recombinant Mouse SAFB Protein	Mammalian Cell	His		Inquiry
Mouse	Safb-2042M	Recombinant Mouse Safb Protein, His&GST-tagged	E.coli	N-His&GST	Ala2-Ser235	Inquiry
Mouse	SAFB-7884M	Recombinant Mouse SAFB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SAFB-7884M-B	Recombinant Mouse SAFB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	SAFB-5224R	Recombinant Rat SAFB Protein	Mammalian Cell	His		Inquiry
Rat	SAFB-4883R	Recombinant Rat SAFB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SAFB-4883R-B	Recombinant Rat SAFB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SAFB-12714Z	Recombinant Zebrafish SAFB	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SAFB Related Articles

SAFB involved in several pathways and played different roles in them. We selected most pathways SAFB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SAFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SAFB has several biochemical functions, for example, chromatin binding, core promoter binding, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAFB itself. We selected most functions SAFB had, and list some proteins which have the same functions with SAFB. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	BAP1;SAFB;HMGB2;MSL1;GATA2B;SFPQ;HMGB3A;UBTFL;NSBP1
core promoter binding	PYDC3;FOXP3;CALCOCO1;ARNTL;GATA1;NEUROG3;E2F7;CRY1;AGO2
double-stranded DNA binding	HLF;MCM10;IFI203;PYDC3;SP1;KIN;RAD51L3;FEV;TDG
nucleotide binding	ATP8A1;DCKL1B;FPGS;EXOSC10;PEO1;ATP1A2A;RABL2;DHX32A;GNAO1B
poly(A) RNA binding	TMEM38A;MRPL4;NOLC1;FAM98A;BCCIP;NXF1;C1orf53;DIMT1L;LBR
protein binding	RG9MTD1;HIST1H2BE;C16orf79;STX4;LILRB3;RYR1B;KDM6B;NDOR1;NFKBIA

SAFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAFB here. Most of them are supplied by our site. Hope this information will be useful for your research of SAFB.

TP53; MAP1LC3B; SRPK1; SRPK1; SAFB2; Srek1; CSNK2A1; EEF1D

Schwaiger, E; Wahrmann, M; et al. Complement Component C3 Activation: The Leading Cause of the Prozone Phenomenon Affecting HLA Antibody Detection on Single-Antigen Beads. TRANSPLANTATION 97:1279-1285(2014).

Guidicelli, G; Anies, G; et al. The complement interference phenomenon as a cause for sharp fluctuations of serum anti-HLA antibody strength in kidney transplant patients. TRANSPLANT IMMUNOLOGY 29:17-21(2013).