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SARS2

Official Full Name

seryl-tRNA synthetase 2, mitochondrial
Overview

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
Synonyms

SARS2; seryl-tRNA synthetase 2, mitochondrial; SARSM, serine tRNA ligase, mitochondrial , seryl tRNA synthetase 2; seryl-tRNA synthetase, mitochondrial; FLJ20450; mtSerRS; SARS; serine tRNA ligase 2; mitochondrial; SerRSmt; SERS; SYS; SARSM; Serine tRNA ligase; Serine--tRNA ligase; SerRS; Seryl tRNA synthetase 2; Seryl-tRNA synthetase; Seryl-tRNA(Ser/Sec) synthetase; SYSM_HUMAN; serine-tRNA ligase, mitochondrial; mitochondrial seryl-tRNA synthetase; serine tRNA ligase 2, mitochondrial;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SARS2-2513H	Recombinant Human SARS2, GST-tagged	E.coli	GST	169-518aa	$319 / 25ug
Human	SARS2-2060HCL	Recombinant Human SARS2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SARS2-2673H	Recombinant Human SARS2 Protein, His-tagged	E.coli	N-His	Leu242-Ser518	Inquiry
Mouse	SARS2-14678M	Recombinant Mouse SARS2 Protein	Mammalian Cell	His		Inquiry
Mouse	SARS2-7904M	Recombinant Mouse SARS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Sars2-5692M	Recombinant Mouse Sars2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Sars2-2043M	Recombinant Mouse Sars2 Protein, His&GST-tagged	E.coli	N-His&GST	Asn277-Arg578	Inquiry
Mouse	SARS2-7904M-B	Recombinant Mouse SARS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SARS2-11396Z	Recombinant Zebrafish SARS2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SARS2 involved in several pathways and played different roles in them. We selected most pathways SARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Aminoacyl-tRNA biosynthesis	WARS2;TARSL2;FARSB;FARS2;HARS2;TARS;KARS;QARS;SARS

SARS2 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, serine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SARS2 itself. We selected most functions SARS2 had, and list some proteins which have the same functions with SARS2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	SMARCA4;BMPR2;PHKG1;ACLY;HIPK3B;NLRP2;ULK3;MYH7B;EPHA2A
poly(A) RNA binding	RPL35;SRSF9;MRPL39;GTF2F1;STAU2;RPL18A;KIAA1429;CPSF4;EIF4H
serine-tRNA ligase activity	SARS2;SARS

SARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SARS2.

HSP90AB1; DMWD; SQSTM1; TRMT10C; USP44; PUF60; TP53; ICT1; IFI16; SIRT4