Background
Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane;trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central;transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is;mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to;function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 (PubMed 11050114)).