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SCMH1

  • Official Full Name

    sex comb on midleg homolog 1

  • Overview

    Polycomb protein SCMH1 is a protein that in humans is encoded by the SCMH1 gene.
  • Synonyms

    SCMH1; sex comb on midleg homolog 1 (Drosophila); polycomb protein SCMH1; Scml3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SCMH1-28619TH Recombinant Human SCMH1, His-tagged E.coli His
Human SCMH1-2534H Recombinant Human SCMH1, GST-tagged E.coli GST C-term-300aa
Human SCMH1-2033HCL Recombinant Human SCMH1 293 Cell Lysate HEK293 N/A
Mouse SCMH1-14750M Recombinant Mouse SCMH1 Protein Mammalian Cell His
Mouse SCMH1-7935M-B Recombinant Mouse SCMH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SCMH1-7935M Recombinant Mouse SCMH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SCMH1-5587Z Recombinant Zebrafish SCMH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SCMH1 Related Articles

SCMH1 involved in several pathways and played different roles in them. We selected most pathways SCMH1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCMH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceUBN1;E2F2;CBX6;CDKN2B;CBX4;EED;TERF2IP;CBX8B;CDKN2A
Cellular responses to stressULK1A;CDKN2B;HBXIP;UVRAG;RNF2;KDM6B;HIF1AN;MAPKAPK2B;ATG9A
Metabolism of proteinsNAPB;MTX2;B3GNT2A;MIA3;DDOST;GRP;PHC3;CEACAM21;PAPPA
Oxidative Stress Induced SenescenceCBX8A;EED;BMI1B;TNIK;RNF2;KDM6B;CBX8B;CBX6A;BMI1A
Post-translational protein modificationDPH5;DNAJC24;ADAMTSL5;BET1;MUC21;SEC23IP;SSPO;DAD1;CTAGE5
SUMO E3 ligases SUMOylate target proteinsCBX8;SCMH1;SMC5;NSMCE2;SMC6;RNF2;CBX4;PHC1;NSMCE1
SUMOylationRNF2;PHC2;PHC1;NSMCE1;NSMCE2;PHC3;SCMH1;SMC5;EID3
SUMOylation of DNA damage response and repair proteinsSMC5;RNF2;CBX8;EID3;PHC2;NSMCE2;PHC3;NSMCE4A;PHC1

SCMH1 has several biochemical functions, for example, DNA binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCMH1 itself. We selected most functions SCMH1 had, and list some proteins which have the same functions with SCMH1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF512;ASH1L;HIST1H2BI;NR0B2A;TIGD6;PNN;TEAD3;EP400;HIST1H2A9
protein bindingANKS4B;AMY1A;BNIP2;PPIA;ANXA11;FBXO32;ZHX1;ARID3B;CLTA
transcription factor activity, sequence-specific DNA bindingRAB11FIP4A;YY1;FOXD5;TSC22D3;FOSL1A;SALL2;MYCS;TFE3;STAT2

SCMH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCMH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCMH1.

MAGEA12; UBQLN1; UBQLN1; LYPLA2; TMEM11; HK1; TOB1; GRINL1A; PHC2; UBQLN4; MOB4; Bmi1; Cbx2

Takada, Y; Isono, KI; et al. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. DEVELOPMENT 134:579-590(2007).
Sathyamurthy, A; Allen, MD; et al. Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2). JOURNAL OF BIOLOGICAL CHEMISTRY 278:46968-46973(2003).
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