SCN9A
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Official Full Name
sodium channel, voltage-gated, type IX, alpha subunit
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Overview
Nav1.7 is a voltage-gated sodium channel that plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and this can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals. -
Synonyms
SCN9A; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage gated, type IX, alpha polypeptide; sodium channel protein type 9 subunit alpha; ETHA; Nav1.7; NE NA; NENA; PN1; hNE-Na; peripheral sodium channel 1; neuroendocrine sodiu;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SCN9A-27560TH | Recombinant Human SCN9A protein, GST-tagged | Wheat Germ | GST | ||
| Rat | SCN9A-5270R | Recombinant Rat SCN9A Protein | Mammalian Cell | His |
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| Rat | SCN9A-4929R | Recombinant Rat SCN9A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | SCN9A-4929R-B | Recombinant Rat SCN9A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | SCN9A-5570C | Recombinant Chicken SCN9A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
SCN9A involved in several pathways and played different roles in them. We selected most pathways SCN9A participated on our site, such as Axon guidance, Developmental Biology, Interaction between L1 and Ankyrins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCN9A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | ACTR2B;GSK3B;ROBO3;SEMA3G;Ntng2;SEMA6B;SPTA1;SCN8A;ABLIM1 |
| Developmental Biology | MED29;PEA15A;NR2F2;MARK3;PAQR3A;DCX;FGF8B;FGF20A;EFNB2 |
| Interaction between L1 and Ankyrins | SCN3A;SCN8A;SCN2B;SCN4A;ANK2B;SCN9A;KCNQ2;KCNQ3;SCN2A |
| L1CAM interactions | SCN4A;SCN3A;CHL1;KIF4A;RANBP9;DPYSL2;KCNQ3;NADL1.1;DCX |
SCN9A has several biochemical functions, for example, sodium ion binding, voltage-gated sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCN9A itself. We selected most functions SCN9A had, and list some proteins which have the same functions with SCN9A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium ion binding | SLC24A4;ATP1A1;SLC24A5;CAPN3;SLC24A1;SLC34A2;SCN9A;SLC24A4A;SLC24A2 |
| voltage-gated sodium channel activity | SCN3B;SCN12AA;ASIC4A;SCN8A;HCN2;HCN4;SCN11A;SCN1B;PKD2 |
SCN9A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCN9A here. Most of them are supplied by our site. Hope this information will be useful for your research of SCN9A.
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations in SCN9A can result in either increased or decreased pain sensitivity, leading to various pain disorders.
SCN9A research enhances our understanding of nociception, the neural process of encoding and processing harmful stimuli, providing insights into pain mechanisms.
SCN9A mutations are associated with IEM, a condition characterized by severe burning pain in the extremities, often triggered by warmth.
Yes, some clinical trials are exploring drugs that selectively target Nav1.7 to alleviate chronic pain.
Research suggests that modulating Nav1.7 activity, encoded by SCN9A, could be a potential therapeutic approach for pain management.
Customer Reviews (3)
Write a reviewIn addition to its high-quality standards, the manufacturer of SCN9A protein offers excellent technical support.
The SCN9A protein demonstrates outstanding performance in various experimental applications.
This flexibility ensures that the SCN9A protein can address my specific research objectives efficiently.
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