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SCNN1B

Official Full Name

sodium channel, non-voltage-gated 1, beta subunit
Overview

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]
Synonyms

SCNN1B; sodium channel, non-voltage-gated 1, beta subunit; BESC1; ENaCb; SCNEB; ENaCbeta; amiloride-sensitive sodium channel subunit beta; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; sodium channel, nonvoltage-gated 1, beta; nasal epithelial sodium channel beta subunit; nonvoltage-gated sodium channel 1 subunit beta; amiloride-sensitive sodium channel subunit beta 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Ovis aries (Sheep)
Rabbit
Rat

Source

E.coli
E.coli expression system
E.Coli or Yeast
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SCNN1B-3892H	Recombinant Human SCNN1B, His-tagged	E.coli	His	68-401aa	$319 / 25ug
Human	SCNN1B-2028HCL	Recombinant Human SCNN1B 293 Cell Lysate	HEK293	N/A		Inquiry
Rat	Scnn1b-3415R	Recombinant Rat Scnn1b, His-tagged	E.Coli or Yeast	His	638	Inquiry
Rat	SCNN1B-5272R	Recombinant Rat SCNN1B Protein	Mammalian Cell	His		Inquiry
Rat	SCNN1B-4931R	Recombinant Rat SCNN1B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SCNN1B-4931R-B	Recombinant Rat SCNN1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rabbit	SCNN1B-3414R	Recombinant Rabbit SCNN1B, His-tagged	E.Coli or Yeast	His	641	Inquiry
Ovis aries (Sheep)	RFL22222OF	Recombinant Full Length Sheep Amiloride-Sensitive Sodium Channel Subunit Beta(Scnn1B) Protein, His-Tagged	E.coli expression system	His	Full Length (1-632)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SCNN1B Related Articles

SCNN1B involved in several pathways and played different roles in them. We selected most pathways SCNN1B participated on our site, such as Taste transduction, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCNN1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Taste transduction	TAS2R113;GNB1;TAS2R124;TAS2R42;PRKACB;TAS2R121;TAS2R3;TAS2R117;ITPR3
Aldosterone-regulated sodium reabsorption	FXYD4;MAPK3;INSR;ATP1B4;ATP1A3;PRKCB;PIK3R2;SFN;PIK3CA

SCNN1B has several biochemical functions, for example, WW domain binding, contributes_to ligand-gated sodium channel activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCNN1B itself. We selected most functions SCNN1B had, and list some proteins which have the same functions with SCNN1B. You can find most of the proteins on our site.

Function	Related Protein
WW domain binding	LITAF;PPARG;TP63;TCEAL2;TRAF4;FAM189B;PMEPA1;TNK2;TMEM128
contributes_to ligand-gated sodium channel activity	SCNN1A;SCNN1B;SCNN1G
protein binding	HSPA1L;CUL5;CNOT1;RYR1;NEUROD1;DIS3L;GMDS;HK1;ILF2

SCNN1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCNN1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SCNN1B.

NEDD4; NEDD4L; COMMD1

Mutesa, L; Azad, AK; et al. Genetic Analysis of Rwandan Patients With Cystic Fibrosis-Like Symptoms Identification of Novel Cystic Fibrosis Transmembrane Conductance Regulator and Epithelial Sodium Channel Gene Variants. CHEST 135:1233-1242(2009).

Giraldez, T; Afonso-Oramas, D; et al. Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon. JOURNAL OF NEUROCHEMISTRY 102:1304-1315(2007).