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SCP2

  • Official Full Name

    sterol carrier protein 2

  • Overview

    This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
  • Synonyms

    SCP2; sterol carrier protein 2; non-specific lipid-transfer protein; sterol carrier protein X; propanoyl-CoA C-acyltransferase; NLTP; SCPX; SCP-2; SCP-X; NSL-TP; SCP-CHI; DKFZp686C12188; DKFZp686D11188;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SCP2-31466TH Recombinant Human SCP2 Wheat Germ N/A 143 amino acids
Human SCP2-87H Recombinant Human SCP2 Protein, His-tagged E. coli His Ala433~Leu547
Human SCP2-2542H Recombinant Human SCP2, GST-tagged E.coli GST 1-143aa
Human SCP2-2023HCL Recombinant Human SCP2 293 Cell Lysate HEK293 N/A
Human SCP2-02H Recombinant Human SCP2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human SCP2-459HF Recombinant Full Length Human SCP2 Protein In Vitro Cell Free System 143 amino acids
Human SCP2-1239H Recombinant Human SCP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SCP2-2477H Recombinant Human SCP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SCP2-3711H Recombinant Human SCP2 protein, His-tagged E.coli His 405-547 aa
Mouse SCP2-14772M Recombinant Mouse SCP2 Protein Mammalian Cell His
Mouse Scp2-5720M Recombinant Mouse Scp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SCP2-7944M-B Recombinant Mouse SCP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse SCP2-7944M Recombinant Mouse SCP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Scp2-2045M Recombinant Mouse Scp2 Protein, His&GST-tagged E.coli N-His&GST Phe414-Leu547
Rat Scp2-8099R Recombinant Rat Scp2 protein, His & T7-tagged E.coli His/T7 Ala433~Leu547 (Accession # P11915)
Rat SCP2-5275R Recombinant Rat SCP2 Protein Mammalian Cell His
Rat SCP2-4934R-B Recombinant Rat SCP2 Protein Pre-coupled Magnetic Beads HEK293
Rat SCP2-4934R Recombinant Rat SCP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SCP2 Related Articles

SCP2 involved in several pathways and played different roles in them. We selected most pathways SCP2 participated on our site, such as Primary bile acid biosynthesis, Metabolic pathways, PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Primary bile acid biosynthesisCYP46A1.4;HSD3B7;CYP46A1.1;CH25H;CH25HL1.2;AMACR;CH25HL2;CYP46A1.3;SCP2
Metabolic pathwaysALAS1;HIBADH;CYP21A2;ATP5H;PTS;MTMR1;ALDOAB;DOLK;ADH4
PPAR signaling pathwaySLC27A1A;UBC;PPARD;HMGCS2;PCK2;APOA1A;RXRA;PPARG;ACSL3A
PeroxisomeFAR1;PEX19;ECI2;HSD17B4;NOS2B;PEX3;PEX12;ABCD1;ACSL1B

SCP2 has several biochemical functions, for example, cholesterol binding, fatty-acyl-CoA binding, long-chain fatty acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCP2 itself. We selected most functions SCP2 had, and list some proteins which have the same functions with SCP2. You can find most of the proteins on our site.

Function Related Protein
cholesterol bindingSTAR;SYP;NPC2;NR1H3;STARD6;APOE;TSPO2;APOA1;PTCH1
fatty-acyl-CoA bindingACADL;ACBD3;ACAD8;IVD;SOAT1;HMGCL;GCDH;ACBD6;ACBD4
long-chain fatty acyl-CoA bindingACOT7;SCP2;DBI
oleic acid bindingFABP3;SCP2
phosphatidylinositol transporter activityPITPNM1;TNFAIP8L3;PITPNM3;SCP2;PITPNC1;PITPNBL;PITPNA
propanoyl-CoA C-acyltransferase activity
protein bindingCD79B;MYOG;UGGT2;SLC6A18;FAF1;GTF2A1;CDYL2;SLC2A4;SLC4A1A
receptor bindingEDA;PPP2R4;SNX17;FGF20A;SRC;INSL4;LAMA1;ECI2;WNT7A
sterol transporter activityC20orf79;NPC1;SCP2;OSBP;SCP2A

SCP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCP2.

TRIP13; CAV1; Cav1; EPB41; CACNA1A; CREB3; yscL; SF1; sseA; q99ib8-pro_0000045599; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

Kneissel, S; Franke, WW; et al. A novel karyoskeletal protein: Characterization of protein NO145, the major component of nucleolar cortical skeleton in Xenopus oocytes. MOLECULAR BIOLOGY OF THE CELL 12:3904-3918(2001).
Kimura, H; Fujii, H; et al. Lipid-binding proteins in rat and human kidney. KIDNEY INTERNATIONAL 56:S159-S162(1999).
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