SEC63
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Official Full Name
SEC63 homolog (S. cerevisiae)
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Overview
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. -
Synonyms
SEC63; SEC63 homolog (S. cerevisiae); SEC63 like (S. cerevisiae); translocation protein SEC63 homolog; DNAJC23; ERdj2; PRO2507; SEC63L; SEC 63;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rhesus Macaque
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
- Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | SEC63-2569H | Recombinant Human SEC63, His-tagged | E.coli | His | 409-760aa | |
Human | SEC63-1988HCL | Recombinant Human SEC63 293 Cell Lysate | HEK293 | N/A | ||
Human | SEC63-3941H | Recombinant Human SEC63 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Mouse | SEC63-14843M | Recombinant Mouse SEC63 Protein | Mammalian Cell | His | ||
Mouse | Sec63-1003M | Recombinant Mouse Sec63 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | SEC63-7994M-B | Recombinant Mouse SEC63 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | SEC63-7994M | Recombinant Mouse SEC63 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Homo sapiens (Human) | RFL7566HF | Recombinant Full Length Human Translocation Protein Sec63 Homolog(Sec63) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-760) | |
Mus musculus (Mouse) | RFL2678MF | Recombinant Full Length Mouse Translocation Protein Sec63 Homolog(Sec63) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-760) | |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL10111PF | Recombinant Full Length Pongo Abelii Translocation Protein Sec63 Homolog(Sec63) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-761) | |
Rhesus Macaque | SEC63-4130R | Recombinant Rhesus monkey SEC63 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | SEC63-3947R-B | Recombinant Rhesus Macaque SEC63 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | SEC63-3947R | Recombinant Rhesus Macaque SEC63 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RFL32056SF | Recombinant Full Length Saccharomyces Cerevisiae Protein Translocation Protein Sec63(Sec63) Protein, His-Tagged | E.coli expression system | His | Full Length (1-663) | |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | RFL18587SF | Recombinant Full Length Schizosaccharomyces Pombe Translocation Protein Sec63(Sec63) Protein, His-Tagged | E.coli expression system | His | Full Length (1-611) | |
Zebrafish | SEC63-706Z | Recombinant Zebrafish SEC63 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
SEC63 involved in several pathways and played different roles in them. We selected most pathways SEC63 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Protein export, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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IRE1alpha activates chaperones | TPP1;SEC63;CTDSP2;HYOU1;SERP1;HDGF;FKBP14;SEC61B;YIF1A |
Metabolism of proteins | TOMM6;C19orf10;THSD1;CCT7;BCS1L;TRAPPC3;ST8SIA3;TOMM40;IGFBP2A |
Protein export | ARXES1;SRPRB;SRP14;SLC38A8;IMMP1L;SPCS3;SRPR;SEC11C;SPCS1 |
Protein processing in endoplasmic reticulum | UBE2D4;TRAF2;TUSC3;HYOU1;YOD1;HSPA5;MBTPS2;DNAJB11;SELS |
Unfolded Protein Response (UPR) | YIF1A;CXXC1;C19orf10;FKBP14;SEC63;DDX11;KLHDC3;SERP1;WIPI1 |
XBP1(S) activates chaperone genes | SERP1;SEC63;WIPI1;CTDSP2;ASNA1;DNAJB9;C19orf10;DDX11;FKBP14 |
SEC63 has several biochemical functions, for example, poly(A) RNA binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC63 itself. We selected most functions SEC63 had, and list some proteins which have the same functions with SEC63. You can find most of the proteins on our site.
Function | Related Protein |
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poly(A) RNA binding | ZNF638;EIF2S1B;CCDC55;RPP25;CSDA;GLRX3;RBM14;SECISBP2;ADARB1 |
protein binding | ALCAM;RCN3;CCDC137;CD48;LGR4;UBA1;RABGGTB;FAM113A;RFESD |
receptor activity | Siglece;LRRN2;CUL5;Tnfrsf22;AGER;Pla2r1;VMN1R44;ERBB3B;MCC |
SEC63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC63 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC63.
Nxn; PTP4A3; MCC; HLA-B; MAGEA6; MDM2; GSTK1; PHLDA3; NXN; cutF; 15-deoxy-delta(12,14; Irf1; Bub1b
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