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SECISBP2

  • Official Full Name

    SECIS binding protein 2

  • Overview

    The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.
  • Synonyms

    SECISBP2; SECIS binding protein 2; selenocysteine insertion sequence-binding protein 2; DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SECISBP 2; Selenocysteine insertion sequence binding protein 2; OTTHUMP00000021618; OTTHUMP00000069896; SECIS-binding protein 2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SECISBP2-2570H Recombinant Human SECISBP2, GST-tagged E.coli GST C-term-349aa
Human SECISBP2-1987HCL Recombinant Human SECISBP2 293 Cell Lysate HEK293 N/A
Rat SECISBP2-5304R Recombinant Rat SECISBP2 Protein Mammalian Cell His
Rat SECISBP2-4963R Recombinant Rat SECISBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SECISBP2-4963R-B Recombinant Rat SECISBP2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SECISBP2 Related Articles

SECISBP2 involved in several pathways and played different roles in them. We selected most pathways SECISBP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SECISBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SECISBP2 has several biochemical functions, for example, mRNA 3-UTR binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SECISBP2 itself. We selected most functions SECISBP2 had, and list some proteins which have the same functions with SECISBP2. You can find most of the proteins on our site.

Function Related Protein
mRNA 3-UTR bindingFXR1;ELAVL1;RBM24A;RBM38;IGF2BP3;CSDA;RNPS1;CPEB1;HNRNPC
poly(A) RNA bindingDKC1;EIF2AK2;EIF4E;HDGF;GSPT2;SRP19;ZC3H10;BCCIP;PRPF3
protein bindingSYTL2;TULP3;SLC6A12;GEMIN8;METTL9;ZNF843;KRT5;TXNDC16;NACC2
ribonucleoprotein complex bindingUHMK1;PRPF6;BOP1;PRPF31;RNASEL;YBX2;SRP54A;ITCH;PPIH
selenocysteine insertion sequence bindingNCL;SECISBP2

SECISBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SECISBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SECISBP2.

GOLGA2; SMAD9; PA; ATXN7L3; q9wmx2-pro_0000037548

Bubenik, JL; Miniard, AC; et al. Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2. RNA BIOLOGY 11:1402-1413(2014).
Seeher, S; Atassi, T; et al. Secisbp2 Is Essential for Embryonic Development and Enhances Selenoprotein Expression. ANTIOXIDANTS & REDOX SIGNALING 21:835-849(2014).
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