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SENP1

Official Full Name

SUMO1/sentrin specific peptidase 1
Overview

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO);protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also;functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple;transcript variants.
Synonyms

SENP1; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; sentrin-specific protease 1; sentrin/SUMO-specific protease SENP1; SuPr-2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
N/A

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SENP1-686H	Active Recombinant Human SENP1, GST-tagged	E.coli	GST		Inquiry
Human	SENP1-688H	Recombinant Human SENP1 Catalytic Domain, His-tagged	N/A	His		Inquiry
Human	SENP1-687H	Recombinant Human SENP1, His-tagged	E.coli	His		Inquiry
Human	SENP1-2576H	Recombinant Human SENP1, His-tagged	E.coli	His	1-331aa	$319 / 25ug
Human	SENP1-180H	Recombinant Human SENP1, His-tagged	E.coli	His		Inquiry
Human	SENP1-1975HCL	Recombinant Human SENP1 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	SENP1-14878M	Recombinant Mouse SENP1 Protein	Mammalian Cell	His		Inquiry
Mouse	SENP1-8013M-B	Recombinant Mouse SENP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SENP1-8013M	Recombinant Mouse SENP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SENP1 Related Research Area

SENP1 involved in several pathways and played different roles in them. We selected most pathways SENP1 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism of proteins	PFDN2;TIMM22;IGFBP5;ZDHHC2;FBXW9;NAT8B;CCDC59;KCNA3;RHBDL1
Post-translational protein modification	SEC16B;SMC6;ADAMTSL4;GCNT3;MUC21;TRAPPC5;ST6GALNAC1.2;PPP6C;MAGT1
Processing and activation of SUMO	SAE1;SENP5;SENP1;UBA2
Regulation of Androgen receptor activity	GATA2;NR0B1;SRY;APPBP2;TRIM24;HOXB13;SPDEF;KAT7;NR2C2
SUMO is proteolytically processed	SENP1;SENP5
SUMOylation	SENP1;PHC1;SCMH1;UBA2;SMC6;CBX8;SMC5;RING1;SENP5

SENP1 has several biochemical functions, for example, SUMO-specific protease activity, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP1 itself. We selected most functions SENP1 had, and list some proteins which have the same functions with SENP1. You can find most of the proteins on our site.

Function	Related Protein
SUMO-specific protease activity	SENP3;SENP1;SENP3A;SENP3B;SENP5;SENP6
endopeptidase activity	PSMB5;TPP1;PSMB9;CASP1;PSEN2;MMP3;CPS1;P4HB;MME
protein binding	TIMM8A;APOBEC3H;NUCB2;MEAF6;MKNK1;KRAS;DCUN1D1;RNF40;KLF15

SENP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP1.

SUMO1; SUMO3; ypvA; q8clr7_yerpe

Post-translational Modification of NFkB/IkB

Deubiquitinating Enzymes (DUBs)

Ubiquitin-like Modifiers (UBLs) and Regulators