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SENP3

Official Full Name

SUMO1/sentrin/SMT3 specific peptidase 3
Overview

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see;SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are;responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the;conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO;conjugates (Di Bacco et al., 2006 (PubMed 16738315)).
Synonyms

SENP3; SUMO1/sentrin/SMT3 specific peptidase 3; SUMO1/sentrin/SMT3 specific protease 3; sentrin-specific protease 3; DKFZP586K0919; DKFZp762A152; SMT3IP1; SSP3; Ulp1; SUMO-1-specific protease 3; sentrin/SUMO-specific protease 3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SENP3-2577H	Recombinant Human SENP3, His-tagged	E.coli	His	225-574aa	$319 / 25ug
Human	SENP3-1974HCL	Recombinant Human SENP3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SENP3-0895H	Recombinant Human SENP3 Protein (E301-V574), Tag Free	E.coli	No tag	E301-V574	Inquiry
Human	SENP3-0896H	Recombinant Human SENP3 Protein (E301-V574), GST tagged	E.coli	GST	E301-V574	Inquiry
Mouse	SENP3-14880M	Recombinant Mouse SENP3 Protein	Mammalian Cell	His		Inquiry
Mouse	SENP3-8015M-B	Recombinant Mouse SENP3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SENP3-8015M	Recombinant Mouse SENP3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SENP3 Related Articles

SENP3 involved in several pathways and played different roles in them. We selected most pathways SENP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SENP3 has several biochemical functions, for example, SUMO-specific protease activity, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP3 itself. We selected most functions SENP3 had, and list some proteins which have the same functions with SENP3. You can find most of the proteins on our site.

Function	Related Protein
SUMO-specific protease activity	SENP6;SENP3B;SENP1;SENP3;SENP5;SENP3A
endopeptidase activity	CASP1;PSMB2;PSMA5;PSMA6B;KLK1B9;PSMA2;NAPSA;KLK1B8;PARL
protein binding	SCAF8;ANK2;DNMT1;SNX10;CGGBP1;TTC17;TBCB;DGCR6L;LAT2

SENP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP3.

NPM1; PELP1; UBC; WDR18; TEX10; CDK4; CDK6

Yang, YQ; Li, H; et al. Expression and Cell Distribution of SENP3 in the Cerebral Cortex After Experimental Subarachnoid Hemorrhage in Rats: A Pilot Study. CELLULAR AND MOLECULAR NEUROBIOLOGY 35:407-416(2015).

Raman, N; Nayak, A; et al. mTOR Signaling Regulates Nucleolar Targeting of the SUMO-Specific Isopeptidase SENP3. MOLECULAR AND CELLULAR BIOLOGY 34:4474-4484(2014).