SENP5
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Official Full Name
SUMO1/sentrin specific peptidase 5
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Overview
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see;SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are;responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the;conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO;conjugates (Di Bacco et al., 2006 (PubMed 16738315)). -
Synonyms
SENP5; SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5; sentrin-specific protease 5; MGC27076; sentrin/SUMO-specific protease SENP5; FLJ42398; DKFZp564O1016;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- SENP5 Related Articles
SENP5 involved in several pathways and played different roles in them. We selected most pathways SENP5 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | CPN1;PHC1;ANKRD28;ADD1;IGFALS;HDGF;NSFA;CALCA;TRAPPC2 |
| Post-translational protein modification | EIF5A2;MAN1B1;ARSF;DAD1;ARSJ;DPH1;ST8SIA3;RING1;TRAPPC6A |
| Processing and activation of SUMO | SAE1;SENP1;SENP5;UBA2 |
| SUMO is proteolytically processed | SENP1;SENP5 |
| SUMOylation | SAE1;SMC6;NSMCE1;SMC5;RNF2;NSMCE4A;SCMH1;SENP1;PHC2 |
SENP5 has several biochemical functions, for example, SUMO-specific protease activity, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP5 itself. We selected most functions SENP5 had, and list some proteins which have the same functions with SENP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SUMO-specific protease activity | SENP3;SENP1;SENP5;SENP3A;SENP3B;SENP6 |
| endopeptidase activity | FURIN;PSMA2;KLK1B24;KLK1B26;PSMB8F;TMEM59;PSEN2;CTSH;KLK1B3 |
| protein binding | GSTA2;HOXC4;BSG;DNAL4;FPR1;AGFG1;BLOC1S1;PIR;SERPINB3C |
SENP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP5.
ESR1
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