SERPINA3
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Official Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
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Overview
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. -
Synonyms
SERPINA3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; ACT; AACT; GIG24; GIG25; alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Horse
- Human
- Mouse
- E.coli
- HEK293
- Human Cell
- human plasma
- Human Serum
- Mammalian Cell
- Normal Human Serum
- Rabbit
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
- SERPINA3 Related Articles
- SERPINA3 Related Research Area
SERPINA3 involved in several pathways and played different roles in them. We selected most pathways SERPINA3 participated on our site, such as Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Selenium Pathway | CRP;PRDX4;TXNRD2;MSRB1;SELT;TXNRD3IT1;SAA4;ALOX5AP;SAA2-SAA4 |
SERPINA3 has several biochemical functions, for example, DNA binding, protein binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINA3 itself. We selected most functions SERPINA3 had, and list some proteins which have the same functions with SERPINA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP710;MBD1B;POGZ;ZNF234;HIST2H3C;RAD51L3;TAF12;NFIB;LASS5 |
| protein binding | ACTR6;FAN1;PPP1R12A;KISS1R;NOV;MARCH5;CABP1;SPCS1;TMPRSS2 |
| serine-type endopeptidase inhibitor activity | SERPINA1D;WFDC6B;SPINT1B;SERPINB1C;SERPINA11;SERPINB10;A2M;WFDC13;EPPIN |
SERPINA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINA3.
DNAJC1; KLK3; ABCC5; ADH1B; NFKB1; LMNB1; SGCD; ZNRD1; LAMC3; ATP6V1A
- Q&As
- Reviews
Q&As (7)
Ask a questionSerpina3n plays significant roles in various physiological processes, including modulation of the complement cascade, apoptosis, wound healing, and potential implications in Alzheimer's disease.
Recent studies have reported significant roles of Serpina3n during various pathologies, particularly in central nervous system (CNS) insults, making it a potential therapeutic target.
The aim is to compile literature shedding light on the potential therapeutic applications of Serpina3n/SERPINA3 in various diseases. Additionally, a brief comparison between murine Serpina3n and its human ortholog SERPINA3 (α1-antichymotrypsin) is provided to account for their biological roles and significance.
The full range of potential applications of Serpina3n is yet to be fully revealed, but its reported implications, especially in CNS insults, suggest potential therapeutic applications.
Serpina3n is a secretory serine protease inhibitor belonging to clade "a" with unique structural and physiological characteristics. |
Serpina3n inhibits a wide range of proteases, contributing to its diverse physiological roles.
Serpina3n belongs to clade "a" of serine protease inhibitors. |
Customer Reviews (3)
Write a reviewThe product's impact extended to data analysis, with intuitive tools for interpreting experimental results.
The longevity of the product's effects allowed us to study cellular responses over extended timeframes.
We found that the product's support for data analysis and visualization significantly expedited our research.
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