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SERPING1

  • Official Full Name

    serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

  • Overview

    This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
  • Synonyms

    serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; SERPING1; C1IN; C1NH; HAE1; HAE2; C1INH; C1 INH; C1 inhibitor; esterase inhibitor; Serine (or cysteine) proteinase inhibitor clade G member 1; OTTHUMP00000197004; Serpin G1; C1-inhibiting factor; C1-INH;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Plasma
  • Mammalian Cell
  • Mammalian cells
  • Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II)
  • C
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SERPING1-108H Active Recombinant Human SERPING1 protein CHO N/A
Human SERPING1-97H Active Native Human C1 Esterase Inhibitor (C1-INH) Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II) N/A
Human SERPING1-7570H Recombinant Human SERPING1, His-tagged E.coli His 23-500aa
Human SERPING1-280H Recombinant Human SERPING1 Protein, His-tagged E.coli His Pro399~Ala500
Human SERPING1-924H Recombinant Human SERPING1 Protein, His-tagged HEK293 His
Human SERPING1-2344H Active Recombinant Human SERPING1 protein, His-tagged HEK293 His Met1-Ala500
Human SERPING1-2615HCL Recombinant Human SERPING1 cell lysate Human Cell N/A
Human SERPING1-5874H Recombinant Human SERPING1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SERPING1-4711H Recombinant Human SERPING1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SERPING1-6463H Recombinant Human SERPING1 Protein (Asn23-Ala500), C-His tagged Mammalian cells C-His Asn23-Ala500
Human SERPING1-999H Recombinant Human SERPING1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SERPING1-5140H Recombinant Human SERPING1 Protein (Pro399-Ala500), His tagged E.coli His Pro399-Ala500
Human SERPING1-181H Human C1 Inhibitor (Plasma) Reference standard N/A
Human SERPING1-27H Human C1-Inhibitor Reference standard N/A
Human SERPING1-2557H Recombinant Human SERPING1 protein(31-100 aa), C-His-tagged E. coli C-His 31-100 aa
Human SERPING1-73H Native Human C1 Esterase inhibitor Human Plasma N/A
Mouse Serping1-282M Recombinant Mouse Serping1 Protein, His-tagged E.coli His Leu35~Ile179
Mouse SERPING1-14963M Recombinant Mouse SERPING1 Protein Mammalian Cell His
Mouse Serping1-281M Recombinant Mouse Serping1 Protein, His-tagged E.coli His Val211~Ser331
Mouse Serping1-283M Recombinant Mouse Serping1 Protein, His-tagged E.coli His Pro397~Phe495
Mouse Serping1-729M Recombinant Mouse Serping1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse SERPING1-8058M-B Recombinant Mouse SERPING1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SERPING1-8058M Recombinant Mouse SERPING1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Serping1-398M Recombinant Mouse Serping1 Protein, His-tagged E.coli N-His Asp23-Gly504
Mouse Serping1-6801M Recombinant Mouse Serping1 Protein (Ala20-Gly504), C-His tagged Mammalian cells C-His Ala20-Gly504
Rat Serping1-284M Recombinant Rat TRIM21 Protein, His-tagged E.coli His Ser148~Trp270
Rat SERPING1-5345R Recombinant Rat SERPING1 Protein Mammalian Cell His
Rat Serping1-285R Recombinant Rat Serping1 Protein, His-tagged E.coli His Lys406~Glu476
Rat Serping1-534R Recombinant Rat Serping1 Protein, His-tagged HEK293 His Met1-Ala504
Rat SERPING1-5004R-B Recombinant Rat SERPING1 Protein Pre-coupled Magnetic Beads HEK293
Rat SERPING1-5004R Recombinant Rat SERPING1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SERPING1-6673Z Recombinant Zebrafish SERPING1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SERPING1 Related Research Area

SERPING1 involved in several pathways and played different roles in them. We selected most pathways SERPING1 participated on our site, such as Complement and coagulation cascades, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPING1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesC2;C9;Hc;C1S;Serpina1c;F7;MBL1;PLAUR;SERPINA5
PertussisCASP1;Hc;CD14;CXCL6;NOS2;AMCF-II;IL6;ITGB2;MAPK8

SERPING1 has several biochemical functions, for example, protein binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPING1 itself. We selected most functions SERPING1 had, and list some proteins which have the same functions with SERPING1. You can find most of the proteins on our site.

Function Related Protein
protein bindingCFI;NASP;SHISA3;PGR;ADA;DYM;RGL2;TOR1AIP2;NAIF1
serine-type endopeptidase inhibitor activitySERPINA5;FURIN;SERPINB1B;SERPINA3;SERPINA3C;SERPINA3M;SPINK4;PAPLNB;SERPINB1C

SERPING1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPING1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPING1.

p27958-pro_0000037573; f_hcvh; NR4A1; BAG6; purL; smc3; ALB

  • Q&As
  • Reviews

Q&As (5)

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How does the function of SERPING1 protein impact the pathophysiology of HAE? 04/18/2023

SERPING1 protein regulates the activity of C1 esterase inhibitor, which in turn modulates the activity of the complement system, leading to the characteristic symptoms of HAE.

What are the implications of genetic mutations in the SERPING1 gene for HAE patients? 12/08/2022

Genetic mutations in the SERPING1 gene can lead to decreased levels or dysfunctional SERPING1 protein, contributing to the development of HAE.

Can the measurement of SERPING1 protein levels be used to monitor treatment response in HAE patients? 04/25/2021

Yes, monitoring SERPING1 protein levels can help assess the effectiveness of HAE treatments and guide adjustments in therapy if needed.

Are there any other clinical conditions associated with aberrations in SERPING1 protein levels? 03/04/2021

Yes, abnormal levels of SERPING1 protein have been implicated in conditions such as preeclampsia, ischemia-reperfusion injury, and sepsis.

How is the role of SERPING1 protein in HAE treatment evolving with advances in biotechnology? 03/28/2019

Biotechnological advances are enabling the development of novel therapeutic modalities targeting SERPING1 protein, such as gene therapies and monoclonal antibodies.

Customer Reviews (3)

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Reviews
04/22/2023

    With their expertise, I can navigate through experimental hurdles, optimize protocols, and ensure the seamless integration of the SERPING1 protein into my investigations.

    05/14/2020

      The SERPING1 protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.

      12/02/2019

        Their knowledgeable and responsive team stands ready to address any concerns or challenges I may encounter.

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