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SERPINI1

  • Official Full Name

    serpin peptidase inhibitor, clade I (neuroserpin), member 1

  • Overview

    This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    SERPINI1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; PI12; neuroserpin; neuroserpin; PI-12; serpin I1; peptidase inhibitor 12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SERPINI1-646H Active Recombinant Human SERPINI1 E.coli N/A
Human SERPINI1-1670H Recombinant Human SERPINI1 protein E.coli N/A 394
Human SERPINI1-8003H Recombinant Human SERPINI1 protein, His & T7-tagged E.coli His/T7 Thr17~Leu410 (Accession # Q99574)
Human SERPINI1-2345H Recombinant Human SERPINI1 protein, His-tagged HEK293 His Met1-Leu410
Human SERPINI1-2566HCL Recombinant Human SERPINI1 cell lysate Human Cell N/A
Human SERPINI1-3658H Recombinant Human SERPINI1 protein, His-tagged E.coli His 109-410 aa
Human SERPINI1-214S Active Recombinant Human SERPINI1 Protein CHO
Human SERPINI1-01H Active Recombinant Human SERPINI1 Protein, GST-tagged CHO
Mouse Serpini1-2485M Recombinant Mouse Serpini1 protein(Met1-Leu410), His-tagged HEK293 C-His Met1-Leu410
Mouse Serpini1-2461M Recombinant Mouse Coagulation Factor X Insect Cell His
Mouse Serpini1-5518M Recombinant Mouse Serine (or cysteine) Peptidase Inhibitor, Clade I, Member 1 Insect Cell N/A
Mouse SERPINI1-1658MCL Recombinant Mouse SERPINI1 cell lysate Human Cell N/A
Rat SERPINI1-5347R Recombinant Rat SERPINI1 Protein Mammalian Cell His
Rat SERPINI1-5006R Recombinant Rat SERPINI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SERPINI1-5006R-B Recombinant Rat SERPINI1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SERPINI1-4156R Recombinant Rhesus monkey SERPINI1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SERPINI1-3973R-B Recombinant Rhesus Macaque SERPINI1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SERPINI1-3973R Recombinant Rhesus Macaque SERPINI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SERPINI1-6982Z Recombinant Zebrafish SERPINI1 Mammalian Cell His
Chicken SERPINI1-1229C Recombinant Chicken SERPINI1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SERPINI1 Related Research Area

SERPINI1 involved in several pathways and played different roles in them. We selected most pathways SERPINI1 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Validated targets of C-MYC transcriptional activationNDUFAF2;PDCD10;PRDX3;PEG10;HUWE1;SERPINI1;MTDH;MINA;LIN28B

SERPINI1 has several biochemical functions, for example, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINI1 itself. We selected most functions SERPINI1 had, and list some proteins which have the same functions with SERPINI1. You can find most of the proteins on our site.

Function Related Protein
serine-type endopeptidase inhibitor activitySERPINE2;SERPINI2;SPINK7;SERPINB10;WFDC13;PAPLN;SPINK3;WFDC1;SERPINB1L1

SERPINI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINI1.

DEDD

  • Q&As
  • Reviews

Q&As (6)

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What role does SERPINI1 protein play in the prognosis of neurological disorders? 12/07/2019

SERPINI1 proteins may play different roles in the prognosis of different neurological diseases, and further research will help us better understand their specific role in prognosis

Can SERPINI1 protein be a potential therapeutic target? 09/19/2019

Because of its role in neurological disorders, SERPINI1 protein is thought to be a potential target for the treatment of these diseases. However, more research is needed to verify its feasibility.

What is the role of SERPINI1 protein in neurological disorders? 08/16/2019

In some cases, mutations in SERPINI1 proteins can lead to problems with nerve cell connectivity, affecting the normal function of the nervous system, leading to neurological disorders.

Is SERPINI1 protein related to drug therapy? 06/18/2019

Research on SERPINI1 protein is still in its infancy, so there is no specific drug needle to treat it.

Which is the main physiological functions of SERPINI1 protein? 04/30/2019

SERPINI1 proteins are mainly involved in synaptic breeding and the formation of neuronal connections in nerve cells, and play an important role in the normal function of the nervous system.

How to detect the expression of SERPINI1 proteins? 03/23/2019

Commonly used methods include immunohistochemistry, western blotting, and immunohistochemical staining.

Customer Reviews (3)

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Reviews
12/12/2022

    It has strong specificity and selectivity for the target of action, which is suitable for experiments.

    01/09/2022

      The effect is good and has a significant effect on cell growth and proliferation.

      12/30/2020

        Good crystallinity, suitable for crystallography research.

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