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SESN1

Official Full Name

sestrin 1
Overview

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms

SESN1; sestrin 1; sestrin-1; PA26; SEST1; AU044290; MGC142129; RP11-787I22.1; 1110002G11Rik; MGC118148; MGC138241; OTTMUSP00000022799; p53 regulated PA26 nuclear protein; p53 regulated protein PA26; p53-regulated protein PA26; SESN1_HUMAN; OTTHUMP00000016951; OTTHUMP00000016952; OTTHUMP00000016953; p53 activated gene 26;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SESN1-2604H	Recombinant Human SESN1, GST-tagged	E.coli	GST	1-141aa	$319 / 25ug
Human	SESN1-1585HCL	Recombinant Human SESN1 cell lysate		N/A		Inquiry
Mouse	SESN1-14972M	Recombinant Mouse SESN1 Protein	Mammalian Cell	His		Inquiry
Mouse	SESN1-8063M-B	Recombinant Mouse SESN1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Sesn1-358M	Recombinant Mouse Sesn1 Protein, His-tagged	E.coli	His	Gly45~Thr492	$298 / 10ug
Mouse	SESN1-8063M	Recombinant Mouse SESN1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	SESN1-770Z	Recombinant Zebrafish SESN1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SESN1 involved in several pathways and played different roles in them. We selected most pathways SESN1 participated on our site, such as p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SESN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
p signaling pathway	CDK1;PPM1DA;BIDA;CCND1;CD82A;FAS;CCNG1;CCND3;TP53AIP1

SESN1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SESN1 itself. We selected most functions SESN1 had, and list some proteins which have the same functions with SESN1. You can find most of the proteins on our site.

Function	Related Protein

SESN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SESN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SESN1.