SET
-
Official Full Name
SET nuclear oncogene
-
Overview
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SET; SET nuclear oncogene; SET translocation (myeloid leukemia associated); protein SET; 2PP2A; IPP2A2; PHAPII; protein phosphatase type 2A inhibitor; Template Activating Factor I; chromatin remodelling factor; HLA-DR-associated protein II; phosphatase 2A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SET Related Articles
SET involved in several pathways and played different roles in them. We selected most pathways SET participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Condensation of Prophase Chromosomes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle | ANKLE2;CDKN2B;TEX12;NUPL2;E2F2;SMAD4;NUP50;PRKDC;APITD1 |
| Cell Cycle, Mitotic | GINS2;TUBB4B;TUBGCP4;NIPBL;CDCA8;GORASP1;CNEP1R1;SPC24;NEK7 |
| Condensation of Prophase Chromosomes | H3F3D;SETA;NCAPG2;MCPH1;NCAPD3;SETB;SMC2;NCAPH2;H3F3B.1 |
| Gene Expression | ZNF317;ZNF550;QTRT1;ZNF133;ZFP90;MTA1;GPR19;SF3B4;ZNF436 |
| HuR (ELAVL1) binds and stabilizes mRNA | ELAVL1;ANP32A;SETB;SETA;HUG;SET |
| M Phase | ZWILCH;SETB;SKA1;NCAPH;MCPH1;CENPE;ZWINT;ENSA;VRK2 |
| Mitotic Prophase | NEK9;MASTL;SMC2;BLZF1;SETA;GORASP2;VRK2;SMC4;VRK1 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | SETA;ZFP36L1A;KHSRP;ZFP36L1B;ZFP36L1;SET;ELAVL1;TNPO1;ANP32A |
SET has several biochemical functions, for example, DNA binding, histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SET itself. We selected most functions SET had, and list some proteins which have the same functions with SET. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP354A;SPO11;TMPOB;PML;ZNF334;NKX1.2LA;ELF2B;VENT;PPARGC1A |
| histone binding | CD1d1;RBBP4;APBB1;ANP32E;CD1D;SART3;HIST1H4B;HIST1H4F;NCAPD3 |
| protein binding | UBR2;TBC1D1;ICA1;TRIM21;LIG3;PXMP2;CSPP1;TFF3;FFAR2 |
| protein phosphatase inhibitor activity | ARPP19;PTN;ELFN2;PHACTR1;ENSA;GLC8;PPP1R26;PPP1R14C;SET |
| protein phosphatase type 2A regulator activity | PPP2R5A;PPP2R5E;PPP2R2BB;PPP2R2B;PPP2R4;PPP2R3A;PPME1;IGBP1;PPP2R2C |
SET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SET here. Most of them are supplied by our site. Hope this information will be useful for your research of SET.
THAP7; RAC1; UBTF; TBP
- Q&As
- Reviews
Ask a Question for All SET Products
Required fields are marked with *
My Review for All SET Products
Required fields are marked with *
