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SETD8

  • Official Full Name

    SET domain containing (lysine methyltransferase) 8

  • Overview

    SET domain-containing lysine methyltransferase 8 (SET8), also known as PR/SET domain-containing protein 7 (PR/SET7), is a member of a family of histone lysine methyltransferases, each of which contains a conserved catalytic SET domain originally identifie
  • Synonyms

    SETD8; SET domain containing (lysine methyltransferase) 8; N-lysine methyltransferase SETD8; KMT5A; PR Set7; SET07; SET8; PR/SET07; H4-K20-HMTase SETD8; lysine N-methyltransferase 5A; SET domain-containing protein 8; PR/SET domain containing protein 8; PR;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • E.coli
  • HEK293
  • Sf9 Insect Cell
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SETD8-461H Recombinant Human SETD8, GST-tagged E.coli GST
Human SETD8-2608H Recombinant Human SETD8, His-tagged E.coli His 1-352aa
Human SETD8-187H Recombinant Human SETD8 Protein, His-tagged E.coli His 190-352
Human SETD8-1631H Recombinant Human SET Domain Containing (lysine methyltransferase) 8, GST-tagged Sf9 Insect Cell GST
Human SETD8-886H Recombinant Human SETD8, None tagged E.coli N/A
Human SETD8-6964H Recombinant Human SETD8, GST-tagged Sf9 Insect Cell GST Full length
Human SETD8-1924HCL Recombinant Human SETD8 293 Cell Lysate HEK293 N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SETD8 Related Articles
  • SETD8 Related Research Area

SETD8 involved in several pathways and played different roles in them. We selected most pathways SETD8 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lysine degradationSETD8B;EHMT1A;AGPHD1;EHHADH;PLOD3;WHSC1;MLL1;SUV39H1;EHMT1

SETD8 has several biochemical functions, for example, histone-lysine N-methyltransferase activity, p53 binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETD8 itself. We selected most functions SETD8 had, and list some proteins which have the same functions with SETD8. You can find most of the proteins on our site.

Function Related Protein
histone-lysine N-methyltransferase activitySUV420H1;EHMT1B;EZH1;SETD1B;SUV39H1A;AAAS;SETD7;WHSC1L1;MLL1
p53 bindingRNF34;TRIM29;CDKN2A;BANP;NUAK1;SMYD2;TP53;RFWD3;ZFP385C
protein bindingUBE3A;CDIPT;ABCG2;TMEM27;CCDC11;TRAPPC2;SAMD4A;FIS1;MLH3
protein-lysine N-methyltransferase activityMETTL8;SETD7;AAAS;METTL7B;METTL21D;IRF4;EZH2;SETD8;PRMT8B
transcription corepressor activityJUB;AEBP1;WWTR1;CCND1;HOMEZA;TRIM28;SAP18;HOMEZ;CRYM

SETD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD8.

HIST2H4B; TWIST1; FAM9A

Rabello, DD; De Moura, CA; et al. Altered expression of MLL methyltransferase family genes in breast cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 43:653-660(2013).
Yu, N; Huangyang, PW; et al. microRNA-7 Suppresses the Invasive Potential of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Histone Methyltransferase SET8. JOURNAL OF BIOLOGICAL CHEMISTRY 288:19633-19642(2013).
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