Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

SETDB2

Official Full Name

SET domain, bifurcated 2
Overview

Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008]
Synonyms

SETDB2; SET domain, bifurcated 2; CLLD8; CLLL8; KMT1F; C13orf4; histone-lysine N-methyltransferase SETDB2; lysine N-methyltransferase 1F; chronic lymphocytic leukemia deletion region 8; chronic lymphocytic leukemia deletion region gene 8 protein;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SETDB2-1632H	Recombinant Human SET Domain, Bifurcated 2, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	SETDB2-6965H	Recombinant Human SETDB2, GST-tagged	Sf9 Insect Cell	GST	Full length	Inquiry
Mouse	SETDB2-14987M	Recombinant Mouse SETDB2 Protein	Mammalian Cell	His		Inquiry
Mouse	SETDB2-8072M	Recombinant Mouse SETDB2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SETDB2-8072M-B	Recombinant Mouse SETDB2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SETDB2-11790Z	Recombinant Zebrafish SETDB2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SETDB2 Related Articles

SETDB2 involved in several pathways and played different roles in them. We selected most pathways SETDB2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETDB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Lysine degradation	AGPHD1;PIPOX;KMT2E;WHSC1L1;NSD1;SETD8A;MLL5;ALDH9A1B;SETD2

SETDB2 has several biochemical functions, for example, DNA binding, histone methyltransferase activity (H3-K9 specific), protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETDB2 itself. We selected most functions SETDB2 had, and list some proteins which have the same functions with SETDB2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	NR4A2;ZIM3;SSH2;HER6;ETS2;ZFP667;ZNF48;ZKSCAN14;TEAD3
histone methyltransferase activity (H3-K9 specific)	EHMT1;EHMT2;SUV39H1;SUV39H2;SETDB2
protein binding	PCDH17;CTSD;CD2;SYT11;FBXO18;WDR92;C21orf119;KRTAP8-1;WDR25
zinc ion binding	BFAR;NR1D4B;Adamts19;SOLH;ZC3HC1;ZCWPW2;ZCCHC11;ZCCHC13;HRG

SETDB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETDB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETDB2.

ARL14EP; IGHG1

Racz, I; et al. Stationary black holes as holographs II. CLASSICAL AND QUANTUM GRAVITY 31:-(2014).

Ideno, H; Shimada, A; et al. Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. GENE EXPRESSION PATTERNS 13:84-90(2013).