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SGCG

  • Official Full Name

    sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)

  • Overview

    This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).
  • Synonyms

    SGCG; sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); DMDA1, LGMD2C, MAM, sarcoglycan, gamma (35kD dystrophin associated glycoprotein); gamma-sarcoglycan; 35kD dystrophin associated glycoprotein; A4; DAGA4; DMDA; gamma sarcoglycan; limb girdle muscular dystrophy 2C (Duchenne like muscular dystrophy; autosomal recessive); Maghrebian myopathy (autosomal recessive); MGC130048; SCARMD2; SCG3; TYPE; 35 kDa dystrophin associated glycoprotein; Gamma SG; 35 kDa dystrophin-associated glycoprotein; 35DAG; DMDA1; Gamma-SG; LGMD2C; MAM; Sarcoglycan gamma; SGCG_HUMAN; OTTHUMP00000018112; 35kD dystrophin-associated glycoprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mesocricetus auratus (Golden hamster)
  • Mouse
  • Mus musculus (Mouse)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SGCG-28970TH Recombinant Human SGCG Wheat Germ N/A 291 amino acids
Human SGCG-26403TH Recombinant Human SGCG Wheat Germ N/A 100 amino acids
Human SGCG-2629H Recombinant Human SGCG, His-tagged E.coli His 1-291aa
Human SGCG-1887HCL Recombinant Human SGCG 293 Cell Lysate HEK293 N/A
Human SGCG-1905HFL Recombinant Full Length Human SGCG Protein, C-Flag-tagged Mammalian cells Flag
Human SGCG-1996H Recombinant Human SGCG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SGCG-359H Recombinant Human SGCG Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human SGCG-469HF Recombinant Full Length Human SGCG Protein In Vitro Cell Free System 291 amino acids
Human SGCG-1996H-B Recombinant Human SGCG Protein Pre-coupled Magnetic Beads HEK293
Mouse SGCG-15032M Recombinant Mouse SGCG Protein Mammalian Cell His
Mouse SGCG-8099M Recombinant Mouse SGCG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SGCG-8099M-B Recombinant Mouse SGCG Protein Pre-coupled Magnetic Beads HEK293
Mouse Sgcg-5822M Recombinant Mouse Sgcg Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mesocricetus auratus (Golden hamster) RFL14882MF Recombinant Full Length Mesocricetus Auratus Gamma-Sarcoglycan(Sgcg) Protein, His-Tagged E.coli expression system His Full Length (1-291)
Mus musculus (Mouse) RFL29667MF Recombinant Full Length Mouse Gamma-Sarcoglycan(Sgcg) Protein, His-Tagged E.coli expression system His Full Length (1-291)
Zebrafish SGCG-1087Z Recombinant Zebrafish SGCG Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SGCG Related Articles

SGCG involved in several pathways and played different roles in them. We selected most pathways SGCG participated on our site, such as Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGCG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hypertrophic cardiomyopathy (HCM)CACNA2D1;ITGA7;LMNA;ACTB;CACNB3;PRKAA2;CACNG7;Itga10&Itgb1;TNF
Arrhythmogenic right ventricular cardiomyopathy (ARVC)SGCA;CACNA2D2;GJA1;ITGB3;JUP;DSC2;ACTN2;ITGB5;DAG1
Dilated cardiomyopathyITGB7;CACNA2D3;CACNB4;IGF1;ITGB3;PLN;CACNG1;Itga10&Itgb1;TPM2
Viral myocarditisHLA-DMB;CXADR;EIF4G3;HLA-DMA;FYN;CD40LG;HLA-DOB;HLA-B;HLA-G

SGCG has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SGCG itself. We selected most functions SGCG had, and list some proteins which have the same functions with SGCG. You can find most of the proteins on our site.

Function Related Protein
protein bindingAAK1;COG8;ZG16;NTN4;ITGB3;RTN1;RPS20;COX5B;FMNL1

SGCG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGCG here. Most of them are supplied by our site. Hope this information will be useful for your research of SGCG.

FLNC; DNAJB6; DYSF; ACO1; PTPN11; ENO1; PSAP; HSPA1A; PYGM; ENO3; CCT6A; MYBPC1; MYBPC2

Boulay, AC; Saubamea, B; et al. The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels. FRONTIERS IN CELLULAR NEUROSCIENCE 9:-(2015).
Goldstein, JA; Bogdanovich, S; et al. Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. HUMAN MOLECULAR GENETICS 23:6722-6731(2014).
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