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SGK1

  • Official Full Name

    serum/glucocorticoid regulated kinase 1

  • Overview

    This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Synonyms

    SGK1; serum/glucocorticoid regulated kinase 1; serum/glucocorticoid regulated kinase , SGK; serine/threonine-protein kinase Sgk1; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1; SGK;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Hi-5 Insect Cell
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SGK1-577H Active Recombinant Human SGK1, GST-tagged Sf9 Insect Cell GST
Human SGK1-4993H Active Recombinant Human SGK1 protein, GST-tagged Insect Cell GST M1-L431
Human SGK1-3920H Active Recombinant Human SGK1 protein, His-tagged Insect Cell His
Human SGK1-222H Active Recombinant Human SGK1(S422D)(60-end) Mutation Protein, N-His-tagged Sf21 His 60-end
Human SGK1-223H Unactive Recombinant Human SGK1(S422D)(60-end) Mutation Protein, N-His-tagged Sf21 His 60-end
Human SGK1-428H Recombinant Human SGK1, GST-tagged, Active Sf9 Insect Cell GST
Human SGK1-30970TH Recombinant Human SGK1 N/A
Human SGK1-1346H Recombinant Human Serum/Glucocorticoid Regulated Kinase 1, His-tagged Hi-5 Insect Cell His 60-431aa
Human SGK1-755H Recombinant Human SGK1, T7-tagged E.coli T7
Human SGK1-644H Recombinant Human SGK1, GST-tagged E.coli GST
Human SGK1-1080H Recombinant Human SGK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SGK1-2811H Recombinant Human SGK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SGK1-1185H Recombinant Human SGK1 Protein (S61-L431), His/GST tagged Insect Cell His/GST S61-L431
Human SGK1-1184H Recombinant Human SGK1 Protein (S61-L431), Tag Free Insect Cell No tag S61-L431
Human SGK1-22H Recombinant Human SGK1 Protein, His-tagged E. coli His 60-431 aa
Human SGK1-6273H Recombinant Human SGK1 Protein (Met1-Leu431), N-His tagged E.coli N-His Met1-Leu431
Mouse Sgk1-145M Recombinant Mouse Sgk1 protein, His-tagged E.coli His Ser145~Asp386
Mouse SGK1-15035M Recombinant Mouse SGK1 Protein Mammalian Cell His
Mouse SGK1-8101M-B Recombinant Mouse SGK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sgk1-5824M Recombinant Mouse Sgk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SGK1-8101M Recombinant Mouse SGK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SGK1-9896Z Recombinant Zebrafish SGK1 Mammalian Cell His
Chicken SGK1-6046C Recombinant Chicken SGK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SGK1 Related Articles
  • SGK1 Related Research Area
  • SGK1 Related Signal Pathway

SGK1 involved in several pathways and played different roles in them. We selected most pathways SGK1 participated on our site, such as FoxO signaling pathway, PIK-Akt signaling pathway, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayPCK1;MAP2K2;G6PCA.1;PIK3CG;HOMER3;IGF1RA;MAPK11;CDKN2B;SMAD2
PIK-Akt signaling pathwayVEGFA;FGF8;IL3RA;KITLG;YWHAB;MAP2K2;PPP2CA;IFNA8;ITGA8
Aldosterone-regulated sodium reabsorptionINSR;NR3C2;ATP1A2;PIK3CB;PRKCB;ATP1B3;PRKCA;SLC9A3R2;MAPK3

SGK1 has several biochemical functions, for example, ATP binding, calcium channel regulator activity, chloride channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SGK1 itself. We selected most functions SGK1 had, and list some proteins which have the same functions with SGK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACTR8;EPHA2A;MAP2K2B;PFKFB2A;MVDA;RAD54B;MAPK12B;STK19;ATP8B5
calcium channel regulator activityPRKCB;SGK2B;CRISP1;SGK1;CACNA2D3;NRXN1;TSPAN13;PRKG1;STIM1
chloride channel regulator activityCHRNA7;SGK2B;SGK3;SGK2;SGK1;BSND;SGK2A;SLC9A3R1
potassium channel regulator activityARPP19A;DRD2;DRD4;KCNE1L;KCNE2;YWHAE;NEDD4L;KCNMB2;KCNAB2
protein bindingSHMT2;EIF3M;TM4SF4;FEN1;PRKRIR;DAXX;MAB21L2;SOX7;UNC13A
protein serine/threonine kinase activitySTK40;IRAK4;MAP2K5;STRC;NIM1K;BRAF;OXSR1A;CSNK1D;CSNK1A1
protein serine/threonine/tyrosine kinase activityAKT1;DSTYK;RPS6KA2;DYRK1AA;DYRK1B;DYRK4;AURKA;CLK4;AURKC
sodium channel regulator activityFXYD6;TMPRSS3;YWHAH;SCN1BB;PKP2;GPLD1;SGK2;SCLT1;FXYD7

SGK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGK1.

CREB1; RABAC1; PDPK1; GADD45G; MAPT; IKBKG; Tcr-alpha; 13514813; PPIAL4D; EIF3F; PFAS; CS; CBR3; LETM1

Qadri, SM; Su, Y; et al. Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal. CARDIOVASCULAR DIABETOLOGY 13:-(2014).
Heller, BA; Ghidinelli, M; et al. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. JOURNAL OF CELL BIOLOGY 204:1219-1236(2014).
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