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SHANK1

  • Official Full Name

    SH3 and multiple ankyrin repeat domains 1

  • Overview

    SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene.
  • Synonyms

    SHANK1; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; somatostatin receptor interacting protein; SPANK 1; SSTRIP; synamon; SSTR-interacting protein; somatostatin receptor-interacting protein; SPANK-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Mouse
  • Rat
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse SHANK1-15084M Recombinant Mouse SHANK1 Protein Mammalian Cell His
Mouse SHANK1-8135M-B Recombinant Mouse SHANK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SHANK1-8135M Recombinant Mouse SHANK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SHANK1-5385R Recombinant Rat SHANK1 Protein Mammalian Cell His
Rat SHANK1-5044R Recombinant Rat SHANK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SHANK1-5044R-B Recombinant Rat SHANK1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SHANK1 Related Articles

SHANK1 involved in several pathways and played different roles in them. We selected most pathways SHANK1 participated on our site, such as Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHANK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glutamatergic synapseSHANK1;PLCB3;ITPR1;PRKACG;GRIK2;GRIN3B;SHANK3;GRIN2A;GRIN2C

SHANK1 has several biochemical functions, for example, GKAP/Homer scaffold activity, SH3 domain binding, ankyrin repeat binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHANK1 itself. We selected most functions SHANK1 had, and list some proteins which have the same functions with SHANK1. You can find most of the proteins on our site.

Function Related Protein
GKAP/Homer scaffold activitySHANK1;HOMER2;SHANK3
SH3 domain bindingQKI2;ABL1;KHDRBS2;OSTF1;DOCK1;ARHGAP1;PDE4D;ERRFI1;PARK2
ankyrin repeat bindingHIF1AN;RELA;SHANK1
identical protein bindingZNF212;PICK1;DCP1A;TRP63;TPD52L1;MCPH1;PKD2L1;ANXA4;ALDOA
ionotropic glutamate receptor bindingDRD2;SHANK2;DLG4B;ADRB2;DLG1;FLOT2;DLG1L;IL1R1;NETO1
protein C-terminus bindingNEIL1;KPNA3;DAB2;TNNI3K;HSPB7;PROP1;XRCC4;ATP2A2;RAD51
protein complex bindingSIX2;ABI1;KCTD5;AP2A2;ST13;AP2B1;HSPD1;LCK;VDAC1
receptor signaling complex scaffold activityCD3E;GRIP1;NUP62;SPAG9A;SHANK1;NCK1;LDLRAP1;AXIN1;G3BP2
scaffold protein bindingKCNA5;MAPK3;PARK7;GRIN2A;MAP2K2;NOS1;TREM1;P2RY1;NLGN3
somatostatin receptor binding

SHANK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHANK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHANK1.

Dlg4

Tao-Cheng, JH; Dosemeci, A; et al. ACTIVITY INDUCED CHANGES IN THE DISTRIBUTION OF SHANKS AT HIPPOCAMPAL SYNAPSES. NEUROSCIENCE 168:11-17(2010).
Uemura, T; Mori, H; et al. Direct interaction of GluR delta 2 with Shank scaffold proteins in cerebellar Purkinje cells. MOLECULAR AND CELLULAR NEUROSCIENCE 26:330-341(2004).
Lim, S; Naisbitt, S; et al. Characterization of the Shank family of synaptic proteins - Multiple genes, alternative splicing, and differential expression in brain and development. JOURNAL OF BIOLOGICAL CHEMISTRY 274:29510-29518(1999).
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