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SHANK3

Official Full Name

SH3/ankyrin domain gene 3
Overview

SH3 and multiple ankyrin repeat domains 3, also known as SHANK3, is a human gene on chromosome 22.
Synonyms

SHANK3; SH3/ankyrin domain gene 3; SH3 and multiple ankyrin repeat domains protein 3; AI841104; DEL22q13.3; KIAA1650; Proline rich synapse associated protein 2; ProSAP2; PSAP2; SH3 and multiple ankyrin repeat domains 3; Shank postsynaptic density protein; Shank3b; SPANK 2; SPANK2; SPANK-2; proline-rich synapse-associated protein 2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Human cells
Mammalian Cell

Tag

DYKDDDDK
GST
His
His (Fc)
Avi
Myc
DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SHANK3-01H	Recombiant Human SHANK3 Protein, DYKDDDDK-tagged	Human cells	DYKDDDDK		Inquiry
Human	SHANK3-301390H	Recombinant Human SHANK3 protein, GST-tagged	E.coli	GST	Met358-Ala457	Inquiry
Mouse	SHANK3-15086M	Recombinant Mouse SHANK3 Protein	Mammalian Cell	His		Inquiry
Mouse	SHANK3-8137M-B	Recombinant Mouse SHANK3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SHANK3-8137M	Recombinant Mouse SHANK3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Shank3-5852M	Recombinant Mouse Shank3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	SHANK3-5387R	Recombinant Rat SHANK3 Protein	Mammalian Cell	His		Inquiry
Rat	SHANK3-5046R-B	Recombinant Rat SHANK3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	SHANK3-5046R	Recombinant Rat SHANK3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SHANK3 Related Articles

SHANK3 involved in several pathways and played different roles in them. We selected most pathways SHANK3 participated on our site, such as Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHANK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glutamatergic synapse	PLCB3;ADRBK2;GLS2;SLC1A7;GRM3;MAPK3;SLC38A3;GRIK3;GRM1

SHANK3 has several biochemical functions, for example, GKAP/Homer scaffold activity, SH3 domain binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHANK3 itself. We selected most functions SHANK3 had, and list some proteins which have the same functions with SHANK3. You can find most of the proteins on our site.

Function	Related Protein
GKAP/Homer scaffold activity	HOMER2;SHANK1;SHANK3
SH3 domain binding	DENND1A;DNM2;ADAM10;FAM125A;ARHGAP6;QKI2;NCF1;ABL1;INPP5D
actin binding	MYH9;MYO1H;ALKBH4;KPTN;DBNLB;PLECA;MYRIP;MYH15;CXCR4
identical protein binding	RAD52;DYNLT1B;Serpina1b;CLDN2;ATXN3;IFI16;ALDOB;PHYKPL;MYBPC3
ionotropic glutamate receptor binding	DLG1;FLOT2;CACNG2;SHANK3;NETO1;SHANK1;ADRB2;DLG1L;DLG3
protein C-terminus binding	EFHC1;KCNK3;DLG4;ATXN2;KSR1;PLEKHB1;BCAM;RBFOX1;RABAC1
protein binding	WHSC1;C14orf118;ZNF187;DDIT3;KLRC4-KLRK1;ERCC3;PDZD7;MARK3;POMP
protein self-association	TRIM32;TTN;MDH2;CTSC;ZNF496;TMEM190;TMEM43;RYR2;TRP53
scaffold protein binding	TREM1;KRT8;TREM2;GRID2;CASP8;MAPK3;SHANK1;DLG4;KCNA5
zinc ion binding	RNF111;RNF148;NR1I2;MMP1;MT1B;UQCRC2;ITGB1BP2;RNF180;WHSC1L1

SHANK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHANK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHANK3.

Shank1; Nphp4; Ywhae; Ywhab; Bsn

Kouser, M; Speed, HE; et al. Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission. JOURNAL OF NEUROSCIENCE 33:18448-18468(2013).

Raab, M; Boeckers, TM; et al. PROLINE-RICH SYNAPSE-ASSOCIATED PROTEIN-1 AND 2 (ProSAP1/Shank2 AND ProSAP2/Shank3)-SCAFFOLDING PROTEINS ARE ALSO PRESENT IN POSTSYNAPTIC SPECIALIZATIONS OF THE PERIPHERAL NERVOUS SYSTEM. NEUROSCIENCE 171:421-433(2010).